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Product Details
PA5-120890
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 346-475 of human ATXN10 (NP_037368.1).
Conjugate
Form
Liquid
Concentration
1.46 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2914462
Product Specific Information
Positive test controls include: HeLa, SKOV3, LO2, HL-60, 293T, Mouse heart, Mouse kidney, Mouse liver, Rat testis. The target is usually found in the following locations: Cytoplasm, perinuclear region.
Immunogen sequence: ETTNIFSNCG CVRAEGDISN VANGFKSHLI RLIGNLCYKN KDNQDKVNEL DGIPLILDNC NISDSNPFLT QWVIYAIRNL TEDNSQNQDL IAKMEEQGLA DASLLKKVGF EVEKKGEKLI LKSTRDTPKP
Target Information
The autosomal dominant cerebellar ataxias (ADCAs) are a clinically and genetically heterogeneous group of disorders characterized by ataxia, dysarthria, dysmetria, and intention tremor. All ADCAs involve some degree of cerebellar dysfunction and a varying degree of signs from other components of the nervous system. A commonly accepted clinical classification (Harding, 1993) divides ADCAs into 3 different groups based on the presence or absence of associated symptoms such as brainstem signs or retinopathy. The presence of pyramidal and extrapyramidal symptoms and ophthalmoplegia makes the diagnosis of ADCA I, the presence of retinopathy points to ADCA II, and the absence of associated signs to ADCA III. Genetic linkage and molecular analyses revealed that ADCAs are genetically heterogeneous even within the various subtypes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ataxin 10 homolog; Ataxin-10; Brain protein E46; Brain protein E46 homolog; Neuronal beta-catenin-like protein; spinocerebellar ataxia 10; spinocerebellar ataxia 10 homolog; Spinocerebellar ataxia type 10 protein; Spinocerebellar ataxia type 10 protein homolog; testis expressed gene 169
Gene Aliases: AI325283; ATXN10; C77170; E46; E46L; HUMEEP; SCA10; TEG-169; Tex169
UniProt ID: (Human) Q9UBB4, (Rat) Q9ER24, (Mouse) P28658
Entrez Gene ID: (Human) 25814, (Rat) 170821, (Mouse) 54138
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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