Proteintech

ATXN2L Polyclonal Antibody

ATXN2L Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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ATXN2L Antibody (24822-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using (Product # 24822-1-AP) (ATXN2L antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

ATXN2L Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

24822-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 6 publications 6 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ATXN2L Fusion Protein Ag20581 (712-162 aa encoded by BC082760)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.29 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: SYIPQIHMG PAVQAPQMYP YPVSNSVPGQ QGKYRGAKGS LPPQRSDQHQ PASAPPMMQA AAAAGPPLVA ATPYSSYIPY NPQQFPGQPA MMQPMAHYPS QPVFAPMLQS NPRMLTSGSH PQAIVSSSTP QYPSAEQPTP QALYATVHQS YPHHATQLHA HQPQPATTPT GSQPQSQHAA PSPVQHQAGQ APHLGSGQPQ QNLYHPGALT GTPPSLPPGP SAQSPQSSFP QPAAVYAIHH QQLPHGFTNM AHVTQAHVQT GITAAPPPHP GAPHPPQVML LHPPQSHGGP PQGAVPQSGV PALSASTPSP YPYIGHPQGE QPGQAPGFPG GADDRILQSH PSQQLPFHPP GN (712-162 aa encoded by BC082760)

Target Information

This gene encodes an ataxin type 2 related protein of unknown function. This protein is a member of the spinocerebellar ataxia (SCAs) family, which is associated with a complex group of neurodegenerative disorders. Several alternatively spliced transcripts encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Diverse CMT2 neuropathies are linked to aberrant G3BP interactions in stress granules.

Cell

Cui Q,Bi H,Lv Z,Wu Q,Hua J,Gu B,Huo C,Tang M,Chen Y,Chen C,Chen S,Zhang X,Wu Z,Lao Z,Sheng N,Shen C,Zhang Y,Wu ZY,Jin Z,Yang P,Liu H,Li J,Bai G

Thu Feb 16 00:00:00 UTC 2023

Diverse CMT2 neuropathies are linked to aberrant G3BP interactions in stress granules.

Cell

Cui Q,Bi H,Lv Z,Wu Q,Hua J,Gu B,Huo C,Tang M,Chen Y,Chen C,Chen S,Zhang X,Wu Z,Lao Z,Sheng N,Shen C,Zhang Y,Wu ZY,Jin Z,Yang P,Liu H,Li J,Bai G

Thu Feb 16 00:00:00 UTC 2023

Jatrorrhizine ameliorates Schwann cell myelination via inhibiting HDAC3 ability to recruit Atxn2l for regulating the NRG1-ErbB2-PI3K-AKT pathway in diabetic peripheral neuropathy mice.

Phytotherapy research : PTR

Gong X,Gui Z,Ye X,Li X

Wed Feb 01 00:00:00 UTC 2023

Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders.

Cell genomics

Pintacuda G,Hsu YH,Tsafou K,Li KW,Martín JM,Riseman J,Biagini JC,Ching JKT,Mena D,Gonzalez-Lozano MA,Egri SB,Jaffe J,Smit AB,Fornelos N,Eggan KC,Lage K

Wed Mar 08 00:00:00 UTC 2023

Deorphanizing Caspase-3 and Caspase-9 Substrates In and Out of Apoptosis with Deep Substrate Profiling.

ACS chemical biology

Araya LE,Soni IV,Hardy JA,Julien O

Fri Nov 19 00:00:00 UTC 2021

Mid-Gestation lethality of Atxn2l-Ablated Mice.

International journal of molecular sciences

Key J,Harter PN,Sen NE,Gradhand E,Auburger G,Gispert S

Mon Jul 20 00:00:00 UTC 2020

ATXN2L upregulated by epidermal growth factor promotes gastric cancer cell invasiveness and oxaliplatin resistance.

Cell death & disease

Lin L,Li X,Pan C,Lin W,Shao R,Liu Y,Zhang J,Luo Y,Qian K,Shi M,Bin J,Liao Y,Liao W

Wed Feb 20 00:00:00 UTC 2019

Bioinformatics

Protein Aliases: ataxin 2 related protein; ataxin 2-like; Ataxin-2 domain protein; Ataxin-2-like protein; Ataxin-2-related protein

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Gene Aliases: A2D; A2LG; A2LP; A2RP; ATXN2L; Atxnl2

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UniProt ID: (Human) Q8WWM7, (Mouse) Q7TQH0

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Entrez Gene ID: (Human) 11273, (Mouse) 233871

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Function(s)

protein binding poly(A) RNA binding cadherin binding involved in cell-cell adhesion

Process(es)

regulation of cytoplasmic mRNA processing body assembly stress granule assembly cell-cell adhesion

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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ATXN2L Polyclonal Antibody

ATXN2L Antibody (24822-1-AP) in IHC (P)

Product Details

24822-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunoprecipitation (IP)

Species Reactivity

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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