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Proteintech
AUH Polyclonal Antibody
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Product Details
17079-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
AUH Fusion Protein Ag11265 (1-310 aa encoded by BC020722)
Conjugate
Form
Liquid
Concentration
0.19 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MAAAVAAAP GALGSLHAGG ARLVAACSAW LCPGLRLPGS LAGRRAGPAI WAQGWVPAAG GPAPKRGYSS EMKTEDELRV RHLEEENRGI VVLGINRAYG KNSLSKNLIK MLSKAVDALK SDKKVRTIII RSEVPGIFCA ANLPVPTIAA IDGLALGGGL ELALACDIRV AASSAKMGLV ETKLAIIPGG GGTQRLPRAI GMSLAKELIF SARVLDGKEA KAVGLISHVL EQNQEGDAAY RKALDLAREF LPQGPVAMRV AKLAINQGME VDLVTGLAIE EACYAQTIPT KDRLEGLLAF KEKRPPRYKG E (1-310 aa encoded by BC020722)
Target Information
The methylglutaconyl-CoA hydratase, mitochondrial protein binds to the AU-rich element (ARE), a common element found in the 3' UTR of rapidly decaying mRNA such as c-fos, c-myc and granulocyte/ macrophage colony stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation. AUH is also homologous to enol-CoA hydratase, an enzyme involved in fatty acid degradation, and has been shown to have intrinsic hydratase enzymatic activity. AUH is thus a bifunctional chimera between RNA binding and metabolic enzyme activity. A possible subcellular localization in the mitochondria has been demonstrated for the mouse homolog of this protein which shares 92% identity with the human protein. It has been suggested that AUH may have a novel role as a mitochondrial located AU-binding protein. Human AUH is expressed as a single mRNA species of 1.8 kb, and translated as a 40- kDa precursor protein which is subsequently processed to a 32- kDa mature form.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 3-methylglutaconyl-CoA hydratase; 3-MG-CoA hydratase; AU RNA binding protein/enoyl-coenzyme A hydratase; AU RNA-binding protein/enoyl-Coenzyme A hydratase; AU-binding enoyl-CoA hydratase; AU-binding protein/Enoyl-CoA hydratase; AU-specific RNA-binding enoyl-CoA hydratase; Itaconyl-CoA hydratase; Methylglutaconyl-CoA hydratase, mitochondrial; muAUH
Gene Aliases: AUH; C77140; W91705
UniProt ID: (Human) Q13825, (Mouse) Q9JLZ3
Entrez Gene ID: (Human) 549, (Rat) 361215, (Mouse) 11992
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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