Invitrogen

AXIN1 Monoclonal Antibody (T.618.2)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-14853

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50
-

Immunoprecipitation (IP)

1:50
-
Product Specifications

Species Reactivity

Human, Mouse, Non-human primate

Host/Isotype

Rabbit / IgG

Class

Monoclonal

Type

Antibody

Clone

T.618.2

Immunogen

Recombinant protein of human Axin1

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

140 µg/mL

Purification

Affinity chromatography

Storage buffer

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

Contains

<0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10983681

Product Specific Information

It is not recommended to aliquot this antibody.

Target Information

AXIN1 is a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a disheveled and axin (DIX) domain and is thought to function as a negative regulator of the WNT signaling pathway that regulates embryonic axis formation. AXIN1 interacts with adenomatosis polyposis coli (APC), beta-catenin, glycogen synthase kinase 3 beta, forming a tetrameric complex resulting in the regulation of the stabilization of beta-catenin. Mutations in the AXIN1 gene have been associated various carcinomas, indicating that it also functions as a tumor suppressor.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Axin-1; Axis inhibition protein 1; axis inhibitor 1; fused, mouse, homolog of; hAxin; LA16c-314G4.3; MGC52315; Protein Fused; protein phosphatase 1, regulatory subunit 49

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Gene Aliases: AI316800; AXIN; AXIN1; Fu; fused; Kb; Ki; kinky; knobbly; PPP1R49

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UniProt ID: (Human) O15169, (Mouse) O35625

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Entrez Gene ID: (Human) 8312, (Mouse) 12005

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Function(s)
signal transducer activity GTPase activator activity protein binding beta-catenin binding enzyme binding protein kinase binding receptor signaling complex scaffold activity ubiquitin protein ligase binding protein complex scaffold identical protein binding protein homodimerization activity SMAD binding armadillo repeat domain binding I-SMAD binding p53 binding receptor binding protein C-terminus binding protein domain specific binding protein self-association R-SMAD binding
Process(es)
protein polyubiquitination in utero embryonic development optic placode formation regulation of protein phosphorylation positive regulation of protein phosphorylation nucleocytoplasmic transport apoptotic process signal transduction activation of JUN kinase activity multicellular organism development determination of left/right symmetry sensory perception of sound adult walking behavior cell death dorsal/ventral axis specification dorsal/ventral pattern formation Wnt signaling pathway hemoglobin metabolic process forebrain anterior/posterior pattern specification Wnt-activated signaling pathway involved in forebrain neuron fate commitment cell differentiation protein catabolic process negative regulation of Wnt signaling pathway positive regulation of transforming growth factor beta receptor signaling pathway olfactory placode formation cytoplasmic microtubule organization positive regulation of protein ubiquitination activation of protein kinase activity positive regulation of proteasomal ubiquitin-dependent protein catabolic process erythrocyte homeostasis negative regulation of transcription elongation from RNA polymerase II promoter regulation of catenin import into nucleus post-anal tail morphogenesis termination of G-protein coupled receptor signaling pathway positive regulation of JUN kinase activity positive regulation of GTPase activity cellular protein complex assembly negative regulation of fat cell differentiation positive regulation of protein catabolic process positive regulation of protein kinase activity positive regulation of transcription, DNA-templated positive regulation of JNK cascade embryonic eye morphogenesis axial mesoderm development axial mesoderm formation neurological system process negative regulation of protein metabolic process protein homooligomerization positive regulation of ubiquitin-protein transferase activity muscle cell development canonical Wnt signaling pathway embryonic skeletal joint morphogenesis canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation cellular response to organic cyclic compound genetic imprinting negative regulation of canonical Wnt signaling pathway Wnt signaling pathway involved in somitogenesis positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process positive regulation of peptidyl-threonine phosphorylation positive regulation of peptidyl-serine phosphorylation proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of canonical Wnt signaling pathway beta-catenin destruction complex assembly beta-catenin destruction complex disassembly
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