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Invitrogen
AXIN2 Recombinant Rabbit Monoclonal Antibody (JM11-30)
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Product Details
MA5-32646
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
JM11-30
Immunogen
Synthetic peptide within Human Axin2 aa 55-93
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2809923
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Axil; Axin like protein; Axin-2; Axin-like protein; Axis inhibition protein 2; Conductin; DKFZp781B0869; MGC10366; MGC126582
Gene Aliases: Axi1; AXIL; AXIN2; Conductin; ODCRCS
UniProt ID: (Human) Q9UH84, (Mouse) O88566, (Rat) O70240
Entrez Gene ID: (Human) 8313, (Mouse) 12006, (Rat) 29134
positive regulation of protein phosphorylation
intramembranous ossification
secondary heart field specification
chondrocyte differentiation involved in endochondral bone morphogenesis
regulation of transcription, DNA-templated
cell proliferation
negative regulation of cell proliferation
dorsal/ventral axis specification
positive regulation of epithelial to mesenchymal transition
positive regulation of cell death
Wnt signaling pathway
bone mineralization
regulation of mismatch repair
cellular protein localization
negative regulation of catenin import into nucleus
odontogenesis
positive regulation of GTPase activity
maintenance of DNA repeat elements
negative regulation of osteoblast differentiation
mRNA stabilization
regulation of chondrocyte development
regulation of centromeric sister chromatid cohesion
cellular response to organic cyclic compound
negative regulation of canonical Wnt signaling pathway
Wnt signaling pathway involved in somitogenesis
positive regulation of canonical Wnt signaling pathway
beta-catenin-TCF complex assembly
somitogenesis
cell death
regulation of Wnt signaling pathway
regulation of catenin import into nucleus
termination of G-protein coupled receptor signaling pathway
positive regulation of protein kinase activity
negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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