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Invitrogen
Abciximab Chimeric Recombinant Rabbit Monoclonal Antibody (7E3 (Abciximab))
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Abciximab Chimeric Antibody (MA5-47866) in Flow
Flow Cytometry analysis of Abciximab in Human lymphocytes using Abciximab Chimeric Monoclonal Antibody (Product # MA5-47866). Cells were stained with an isotype control, FITC Chimeric monoclonal antibody (Product # MA5-47752) (panel A), or Abciximab Chimeric Monoclonal Antibody (panel B) at a concentration of 1 µg/mL for 30 mins at RT. After washing, bound antibody was detected using a AF488 conjugated donk... View More
Product Details
MA5-47866
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
7E3 (Abciximab)
Immunogen
CD41 is the integrin alpha chain 2b forming a fibrinogen receptor in heterodimeric complex with beta 3.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.02% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_3074311
Product Specific Information
Specificity: Recognises human CD41.
Target Information
Abciximab is a Fab fragment of the chimeric human-murine monoclonal antibody 7E3. Abciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor, and other adhesive molecules. It also binds to vitronectin (alpha-v-beta-3) receptor found on platelets and vessel wall endothelial and smooth muscle cells. Abciximab binds to the intact platelet GpiIb/IIIa receptor, which is a member of the integrin family of adhesion receptors and the major platelet surface receptor involved in platelet aggregation. This binding is thought to involve steric hindrance and/or conformational alterations which block access of large molecules to the receptor rather than direct interaction with the RGD (arginine-glycine-aspartic acid) binding site of GpiIb/IIIa. By binding to the vitronectin receptor (also known as the alpha-v-beta-3 integrin), abciximab blocks effects mediated by this integrin which include cell adhesion. Furthermore, abciximab blocks Mac-1 receptor on monocytes and neutrophils thus inhibiting monocyte adhesion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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