Invitrogen

Acetyl-SOD2 (Lys68) Polyclonal Antibody

View all (44) SOD2 (MnSOD) antibodies

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Datasheet
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Datasheet
Protocols
Questions & Answers

Product Details

PA5-114697

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human SOD2 around the acetylation site of Lys68.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2899333

Product Specific Information

Antibody detects endogenous levels of SOD2 only when acetylated at Lys68.

Target Information

Superoxide dismutase (SOD) is an antioxidant enzyme involved in the defense system against reactive oxygen species (ROS). SOD catalyzes the dismutation reaction of superoxide radical anion (O2) to hydrogen peroxide, which is then catalyzed to innocuous O2 and H2O by glutathione peroxidase and catalase. Several classes of SOD have been identified. These include intracellular copper, zinc SOD (Cu, Zn-SOD/SOD-1), mitochondrial manganese SOD (Mn-SOD/SOD-2) and extracellular Cu, Zn-SOD (EC-SOD/SOD-3). SOD1 is found in all eukaryotic species as a homodimeric 32 kDa enzyme containing one each of Cu and Zn ion per subunit. The manganese containing 80 kDa tetrameric enzyme SOD2, is located in the mitochondrial matrix in close proximity to a primary endogenous source of superoxide, the mitochondrial respiratory chain. SOD3 is a heparin-binding multimer of disulfide-linked dimers, primarily expressed in human lungs, vessel walls and airways. SOD4 is a copper chaperone for superoxide dismutase (CCS), which specifically delivers Cu to copper/zinc superoxide dismutase. CCS may activate copper/zinc superoxide dismutase through direct insertion of the Cu cofactor.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: indophenoloxidase B; IPO B; manganese SOD; manganese superoxide dismutase; manganese-containing superoxide dismutase; mangano-superoxide dismutase; mitochondrial superoxide dismutase 2; Mn superoxide dismutase; Superoxide dimutase 2, mitochondrial; superoxide dismutase; Superoxide dismutase [Mn], mitochondrial

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Gene Aliases: IPO-B; IPOB; Mn-SOD; MNSOD; MVCD6; Sod-2; SOD2

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UniProt ID: (Human) P04179, (Rat) P07895, (Mouse) P09671

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Entrez Gene ID: (Human) 6648, (Rat) 24787, (Mouse) 20656

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Function(s)
superoxide dismutase activity manganese ion binding identical protein binding DNA binding protein binding oxygen binding oxidoreductase activity metal ion binding
Process(es)
response to reactive oxygen species response to superoxide age-dependent response to oxidative stress age-dependent response to reactive oxygen species response to hypoxia release of cytochrome c from mitochondria liver development detection of oxygen vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure regulation of transcription from RNA polymerase II promoter glutathione metabolic process superoxide metabolic process response to oxidative stress mitochondrion organization heart development aging sensory perception of sound locomotory behavior regulation of blood pressure negative regulation of cell proliferation intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway in response to oxidative stress apoptotic mitochondrial changes response to radiation response to cold post-embryonic development response to manganese ion response to zinc ion response to selenium ion response to gamma radiation response to activity removal of superoxide radicals respiratory electron transport chain hemopoiesis response to nutrient levels oxygen homeostasis response to lipopolysaccharide response to L-ascorbic acid response to silicon dioxide response to isolation stress response to immobilization stress vasodilation response to drug response to hydrogen peroxide superoxide anion generation hydrogen peroxide metabolic process negative regulation of apoptotic process negative regulation of neuron apoptotic process positive regulation of nitric oxide biosynthetic process negative regulation of fat cell differentiation response to cadmium ion negative regulation of fibroblast proliferation neuron development response to axon injury erythrophore differentiation hydrogen peroxide biosynthetic process regulation of catalytic activity protein homooligomerization protein homotetramerization response to electrical stimulus regulation of mitochondrial membrane potential iron ion homeostasis response to hyperoxia response to magnetism cellular response to ethanol negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway oxidation-reduction process
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