Invitrogen

Actin Monoclonal Antibody (AC-40), Cyanine3

Product Details

MA1-24907

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

Immunocytochemistry (ICC/IF)

1:75

Product Specifications

Species Reactivity

Bovine, Dog, Chicken, Fish, Guinea pig, Goat, Hamster, Human, Mollusc, Mouse, Sheep, Pig, Rabbit, Reptile, Rat, Xenopus

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

AC-40

Immunogen

Synthetic actin C-terminal peptide Ser-Gly-Pro-Ser-Ile-Val-His-Arg-Lys-Cys-Phe, attached to a Multiple Antigen Peptide (MAP) backbone.

View immunogen

Conjugate

Cyanine3 Cyanine3 Cyanine3

Excitation/Emission Max

554/566 nm View spectra

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

15mM sodium azide

Storage conditions

4°C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_779141

Product Specific Information

Recommended positive controls: MDCK, human or chicken fibroblast.

Target Information

Actin exists as a ubiquitous protein involved with filament formation that make up large portions of the cytoskeleton. Actin filaments interact with myosin to assist in muscle contraction as well as aiding in cell motility and cytokinesis. In vertebrates there are three groups of actin isoforms: alpha, beta and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exists in most cell types as components of the cytoskeleton and as mediators of internal cell motility.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: a-actin; actin alpha 1; actin alpha cardiac; actin alpha cardiac 1; actin, alpha 1, skeletal muscle; actin, alpha 2, smooth muscle, aorta; Actin, alpha cardiac muscle 1; Actin, alpha skeletal muscle; actin, alpha, cardiac 1; actin, alpha, cardiac muscle 1; actin, alpha, vascular smooth muscle; Actin, aortic smooth muscle; actin, beta; actin, beta, cytoplasmic; Actin, cytoplasmic 1; Actin, cytoplasmic 2; Actin, cytoplasmic type 5; actin, cytoplasmic, type 5; actin, gamma 1; actin, gamma 1 propeptide; actin, gamma 2, smooth muscle, enteric; actin, gamma, cytoplasmic 1; Actin, gamma-enteric smooth muscle; actin-like protein; alpha 1 skeletal muscle actin; alpha actin 1; alpha actin 2; Alpha-actin; alpha-actin cardiac; Alpha-actin-1; Alpha-actin-2; Alpha-actin-3; Alpha-cardiac actin; alpha-sma; alpha-smooth muscle actin; alphac-actin; Atcb; beta actin; beta cytoskeletal actin; Beta-actin; beta-actin FE-3; cardiac actin; cardiac muscle alpha actin 1; Cell growth-inhibiting gene 46 protein; cytoplasmic 1; cytoplasmic 2; Cytoplasmic beta-actin; cytoplasmic type 5; cytoskeletal gamma-actin; deafness, autosomal dominant 20; deafness, autosomal dominant 26; epididymis luminal protein 176; gamma 1 propeptide; gamma non-muscle actin; Gamma-2-actin; Gamma-actin; gamma-enteric smooth muscle actin; nemaline myopathy type 3; pan actin; PS1TP5-binding protein 1; RP5-1068B5.2; skeletal alpha actin; smooth muscle alpha-actin; Smooth muscle gamma-actin; type 5; vascular smooth muscle alpha-actin

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Gene Aliases: 0610041G09Rik; a-SMA; AA959943; AAT6; ACT; ACT-4; ACT-5; Act4; ACTA; Acta-2; ACTA1; ACTA2; ACTA3; ACTB; ACTC; Actc-1; ACTC1; ACTE; ACTG; ACTG1; ACTG2; ACTGE; actin; Actl; ACTL3; Acts; ACTSA; ACTSG; Actsk-1; ACTVS; Actx; AL023024; alphaSMA; ASD5; ASMA; Bact; Beta-actin; BOS_10523; BOS_11389; BOS_19345; BOS_22932; BOS_23286; BOS_23966; BRWS1; BRWS2; CFTD; CFTD1; CFTDM; CMD1R; CMH11; cytoplasmic; DFNA20; DFNA26; E430023M04Rik; E51; GAMMA-ACTIN; GIG46; HEL-176; I79_002310; I79_013242; I79_019066; LVNC4; MPFD; MYMY5; NEM1; NEM2; NEM3; PS1TP5BP1; RCJMB04_1h13; RCJMB04_4h19; SHPM; SMalphaA; SMGA; VSCM; XELAEV_18029136mg; XELAEV_18045052mg

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Entrez Gene ID: (Sheep) 101107662, (Chicken) 421534, (Human) 58, (Bovine) 281592, (Pig) 100154254, (Dog) 488984, (Pig) 733615, (Bovine) 515610, (Human) 59, (Dog) 477587, (Rabbit) 100009271, (Chicken) 423787, (Sheep) 101121051, (Pig) 414396, (Human) 60, (Chicken) 396526, (Dog) 403580, (Pig) 397653, (Rabbit) 100009272, (Bovine) 280979, (Sheep) 443052, (Goat) 102179831, (Dog) 478250, (Chicken) 423298, (Sheep) 101111554, (Pig) 100152267, (Human) 70, (Bovine) 533219, (Rabbit) 100340339, (Goat) 100860883, (Chicken) 415296, (Bovine) 404122, (Sheep) 443340, (Human) 71, (Dog) 475923, (Bovine) 281595, (Human) 72, (Dog) 475792, (Sheep) 101114256, (Chicken) 396084, (Rabbit) 100350318, (Chinese hamster) 100768972, (Mouse) 11459, (Rat) 29437, (Mouse) 11475, (Rat) 81633, (Chinese hamster) 100758575, (Guinea pig) 100722917, (Rat) 81822, (Guinea pig) 100135470, (Mouse) 11461, (Chinese hamster) 100689477, (Rat) 29275, (Guinea pig) 100731953, (Mouse) 11464, (Chinese hamster) 100766388, (Chinese hamster) 100764022, (Rat) 287876, (Mouse) 11465, (Guinea pig) 100731713, (Mouse) 11468, (Chinese hamster) 100768744, (Rat) 25365, (Rabbit) 100009506, (Xenopus) 432314, (Xenopus) 398459

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Function(s)

ATP binding structural constituent of cytoskeleton protein binding myosin binding ADP binding protein kinase binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding kinesin binding Tat protein binding nucleosomal DNA binding identical protein binding nitric-oxide synthase binding ATPase activity ubiquitin protein ligase binding nucleotide binding molecular_function

Process(es)

skeletal muscle thin filament assembly skeletal muscle fiber development retina homeostasis axonogenesis substantia nigra development ATP-dependent chromatin remodeling retina development in camera-type eye platelet aggregation cellular response to electrical stimulus metabolic process actin filament-based movement actomyosin structure organization actin-myosin filament sliding response to drug negative regulation of apoptotic process response to ethanol cardiac myofibril assembly cardiac muscle tissue morphogenesis heart contraction cardiac muscle contraction actin-mediated cell contraction sarcomere organization movement of cell or subcellular component cytoskeleton organization cell junction assembly Fc-gamma receptor signaling pathway involved in phagocytosis positive regulation of gene expression, epigenetic vascular endothelial growth factor receptor signaling pathway ephrin receptor signaling pathway muscle contraction positive regulation of gene expression mesenchyme migration regulation of blood pressure vascular smooth muscle contraction response to virus glomerular mesangial cell development response to calcium ion protein folding chaperone mediated protein folding independent of cofactor response to mechanical stimulus response to extracellular stimulus response to lithium ion cell growth muscle filament sliding skeletal muscle fiber adaptation response to steroid hormone apoptotic process biological_process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Actin Monoclonal Antibody (AC-40), Cyanine3

Product Details

MA1-24907

Western Blot (WB)

Immunocytochemistry (ICC/IF)

Species Reactivity

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Excitation/Emission Max

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

References (0)

Bioinformatics

Performance Guarantee

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