Product References
Identification of new aptamer BC-3 targeting RPS7 from rapid screening for bladder carcinoma.
Genes & diseases
Liu Y,Li J,Ou H,Qi D,Hu B,Xu Y,Hu J,Xiong Y,Xia L,Huang JH,Hu X,Wu E
Published figure using Actin monoclonal antibody (Product # MA5-11869) in Western Blot
Fri Sep 01 00:00:00 UTC 2023
Human cytomegalovirus infection perturbs neural progenitor cell fate via the expression of viral microRNAs.
Journal of medical virology
Jiang X,Liu S,Fu YR,Liu XJ,Li XJ,Yang B,Jiang HF,Shen ZZ,Alemu EA,Vazquez P,Tang Y,Kaarbø M,McVoy MA,Rayner S,Luo MH
MA5-11869 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to characterize the expression of cellular and viral miRNAs in HCMV-infected NPCs during early infection by microarray and identified seven differentially expressed cellular miRNAs and six significantly upregulated HCMV miRNAs.
Wed Feb 01 00:00:00 UTC 2023
Human cytomegalovirus infection perturbs neural progenitor cell fate via the expression of viral microRNAs.
Journal of medical virology
Jiang X,Liu S,Fu YR,Liu XJ,Li XJ,Yang B,Jiang HF,Shen ZZ,Alemu EA,Vazquez P,Tang Y,Kaarbø M,McVoy MA,Rayner S,Luo MH
MA5-11869 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to characterize the expression of cellular and viral miRNAs in HCMV-infected NPCs during early infection by microarray and identified seven differentially expressed cellular miRNAs and six significantly upregulated HCMV miRNAs.
Wed Feb 01 00:00:00 UTC 2023
Human cytomegalovirus infection perturbs neural progenitor cell fate via the expression of viral microRNAs.
Journal of medical virology
Jiang X,Liu S,Fu YR,Liu XJ,Li XJ,Yang B,Jiang HF,Shen ZZ,Alemu EA,Vazquez P,Tang Y,Kaarbø M,McVoy MA,Rayner S,Luo MH
MA5-11869 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to characterize the expression of cellular and viral miRNAs in HCMV-infected NPCs during early infection by microarray and identified seven differentially expressed cellular miRNAs and six significantly upregulated HCMV miRNAs.
Wed Feb 01 00:00:00 UTC 2023
Jag1-Notch cis-interaction determines cell fate segregation in pancreatic development.
Nature communications
Xu X,Seymour PA,Sneppen K,Trusina A,Egeskov-Madsen AR,Jørgensen MC,Jensen MH,Serup P
MA5-11869 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to present a mathematical model to simulate the differentiation of MPCs into PACs and BPs by coupling the gene regulatory network to the spatial distribution of interacting cells.
Sat Jan 21 00:00:00 UTC 2023
Dipyridamole and vascular healing following stent implantation.
Frontiers in cardiovascular medicine
Simard T,Jung R,Di Santo P,Labinaz A,Short S,Motazedian P,Dhaliwal S,Sarma D,Rasheed A,Ramirez FD,Froeschl M,Labinaz M,Holmes DR,Alkhouli M,Hibbert B
MA5-11869 was used in Immunohistochemistry to evaluate the efficacy of DP to mitigate ISR in a pre-clinical rabbit stent model.
Tue Sep 26 00:00:00 UTC 2023
Separation of transcriptional repressor and activator functions in Drosophila HDAC3.
Development (Cambridge, England)
Tang M,Regadas I,Belikov S,Shilkova O,Xu L,Wernersson E,Liu X,Wu H,Bienko M,Mannervik M
MA5-11869 was used in Western Blot to conclude that the crucial functions of HDAC3 in embryo development involve catalytic-dependent gene activation and non-enzymatic repression by several mechanisms, including tethering of loci to the nuclear periphery.
Tue Aug 01 00:00:00 UTC 2023
VCP promotes tTAF-target gene expression and spermatocyte differentiation by downregulating mono-ubiquitylated H2A.
Development (Cambridge, England)
Butsch TJ,Dubuisson O,Johnson AE,Bohnert KA
MA5-11869 was used in Western Blot to highlight VCP as a downstream effector of tTAFs that downregulates H2Aub to facilitate meiotic progression.
Sat Jul 15 00:00:00 UTC 2023
Expression and subcellular localization of USH1C/harmonin in human retina provides insights into pathomechanisms and therapy.
Human molecular genetics
Nagel-Wolfrum K,Fadl BR,Becker MM,Wunderlich KA,Schäfer J,Sturm D,Fritze J,Gür B,Kaplan L,Andreani T,Goldmann T,Brooks M,Starostik MR,Lokhande A,Apel M,Fath KR,Stingl K,Kohl S,DeAngelis MM,Schlötzer-Schrehardt U,Kim IK,Owen LA,Vetter JM,Pfeiffer N,Andrade-Navarro MA,Grosche A,Swaroop A,Wolfrum U
MA5-11869 was used in Immunohistochemistry to provide novel insights into PRC cell biology, USH1C pathophysiology and development of gene therapy treatment(s).
Fri Jan 13 00:00:00 UTC 2023
Inhibiting WEE1 Augments the Antitumor Efficacy of Cisplatin in Urothelial Carcinoma by Enhancing the DNA Damage Process.
Cells
Su YL,Xiao LY,Huang SY,Wu CC,Chang LC,Chen YH,Luo HL,Huang CC,Liu TT,Peng JM
MA5-11869 was used in Western Blot to investigate the antitumor efficacy of the Wee1 inhibitor (AZD-1775) alone or in combination with cisplatin was evaluated in urothelial carcinoma (UC) cell lines and a xenograft mouse model.
Thu May 25 00:00:00 UTC 2023
Deacetylase-dependent and -independent role of HDAC3 in cardiomyopathy.
Journal of cellular physiology
Ren J,Zeng Q,Wu H,Liu X,Guida MC,Huang W,Zhai Y,Li J,Ocorr K,Bodmer R,Tang M
MA5-11869 was used in Western Blot to indicate that HDAC3 plays a deacetylase-independent role in maintaining cardiac contractility and preventing Pericardin deposition as well as a deacetylase-dependent role to maintain triglyceride homeostasis.
Wed Mar 01 00:00:00 UTC 2023
Characterization of dengue virus 3'UTR RNA binding proteins in mosquitoes reveals that AeStaufen reduces subgenomic flaviviral RNA in saliva.
PLoS pathogens
Yeh SC,Diosa-Toro M,Tan WL,Rachenne F,Hain A,Yeo CPX,Bribes I,Xiang BWW,Sathiamoorthy Kannan G,Manuel MC,Missé D,Mok YK,Pompon J
MA5-11869 was used in Western Blotting to characterize the first mosquito RBPs that interact with dengue virus genome, paving the way for leveraging these proteins as potential targets to block virus transmission.
Thu Sep 01 00:00:00 UTC 2022
Protamine Sulfate Is a Potent Inhibitor of Human Papillomavirus Infection In Vitro and In Vivo.
Antimicrobial agents and chemotherapy
Young JM,Zine El Abidine A,Gómez-Martinez RA,Bondu V,Sterk RT,Surviladze Z,Ozbun MA
MA5-11869 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to demonstrate the strong inhibitory activity of the heparin-neutralizing drug protamine sulfate (PS) against HPV infection.
Tue Jan 18 00:00:00 UTC 2022
Exosomes derived from dental pulp stem cells accelerate cutaneous wound healing by enhancing angiogenesis via the Cdc42/p38 MAPK pathway.
International journal of molecular medicine
Zhou Z,Zheng J,Lin D,Xu R,Chen Y,Hu X
Published figure using Actin monoclonal antibody (Product # MA5-11869) in Western Blot
Thu Dec 01 00:00:00 UTC 2022
Amoebal Tubulin Cleavage Late during Infection Is a Characteristic Feature of Mimivirus but Not of Marseillevirus.
Microbiology spectrum
Goyal N,Barai A,Sen S,Kondabagil K
Published figure using Actin monoclonal antibody (Product # MA5-11869) in Western Blot
Wed Dec 21 00:00:00 UTC 2022
Penta-O-Galloyl-β-D-Glucose in Pistacia integerrima Targets AMPK-ULK1 and ERK/STAT3 Signaling Axes to Induce ROS-Independent Autophagic Cell Death in Human Lung Cancer Cells.
Frontiers in pharmacology
Balkrishna A,Mulay VP,Verma S,Srivastava J,Lochab S,Varshney A
MA5-11869 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to propose PGG as a potential AMPK activator and STAT3 inhibitor that can be exploited further in developing adjuvant chemotherapeutics against lung cancer.
Sat Aug 06 00:00:00 UTC 2022
ARID1A loss-of-function induces CpG island methylator phenotype.
Cancer letters
Yamada H,Takeshima H,Fujiki R,Yamashita S,Sekine S,Ando T,Hattori N,Okabe A,Yoshikawa T,Obama K,Katai H,Kaneda A,Ushijima T
MA5-11869 was used in Western Blotting to demonstrate a causal role of AT-rich interactive domain 1A (ARID1A) loss-of-function in CpG island methylator phenotype (CIMP) induction.
Thu Apr 28 00:00:00 UTC 2022
Loss of cytoplasmic FMR1-interacting protein 2 (CYFIP2) induces browning in 3T3-L1 adipocytes via repression of GABA-BR and activation of mTORC1.
Journal of cellular biochemistry
Manigandan S,Yun JW
MA5-11869 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to reveal a previously unidentified mechanism of CYFIP2 in the browning of white adipocytes and emphasized the potential of CYFIP2 as a pharmacotherapeutic target for treating obesity and other metabolic disorders.
Sun May 01 00:00:00 UTC 2022
The insulin and IGF signaling pathway sustains breast cancer stem cells by IRS2/PI3K-mediated regulation of MYC.
Cell reports
Lee JS,Lero MW,Mercado-Matos J,Zhu S,Jo M,Tocheny CE,Morgan JS,Shaw LM
MA5-11869 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to establish a mechanistic connection between the IIS pathway and MYC and highlight a role for IRS2-dependent signaling in breast cancer progression.
Tue Dec 06 00:00:00 UTC 2022
Discovery of surface biomarkers for cell mechanophenotype via an intracellular protein-based enrichment strategy.
Cellular and molecular life sciences : CMLS
Dempsey ME,Chickering GR,González-Cruz RD,Fonseca VC,Darling EM
MA5-11869 was used in Western Blotting to demonstrate a workflow for surface protein discovery associated with cellular mechanophenotype.
Fri May 27 00:00:00 UTC 2022
The Synergistic Effect of Cyclic Tensile Force and Periodontal Ligament Cell-Laden Calcium Silicate/Gelatin Methacrylate Auxetic Hydrogel Scaffolds for Bone Regeneration.
Cells
Lee JJ,Ng HY,Lin YH,Lin TJ,Kao CT,Shie MY
MA5-11869 was used in Western Blotting to show that novel auxetic scaffolds could be fabricated by combining different aspects of science and technology, in order to improve the future chances of clinical applications for bone regeneration.
Wed Jun 29 00:00:00 UTC 2022
Pharmacological and In Silico Analysis of Oat Avenanthramides as EGFR Inhibitors: Effects on EGF-Induced Lung Cancer Cell Growth and Migration.
International journal of molecular sciences
Trabalzini L,Ercoli J,Trezza A,Schiavo I,Macrì G,Moglia A,Spiga O,Finetti F
MA5-11869 was used in Western Blot to reveal a new pharmacological activity of Avns as EGFR tyrosine kinase inhibitors.
Mon Aug 01 00:00:00 UTC 2022
A Structure-based Design Approach for Generating High Affinity BRD4 D1-Selective Chemical Probes.
Journal of medicinal chemistry
Cui H,Divakaran A,Hoell ZJ,Ellingson MO,Scholtz CR,Zahid H,Johnson JA,Griffith EC,Gee CT,Lee AL,Khanal S,Shi K,Aihara H,Shah VH,Lee RE,Harki DA,Pomerantz WCK
MA5-11869 was used in Western Blotting to provide new design rules for selective inhibitors of an individual BET bromodomain.
Thu Feb 10 00:00:00 UTC 2022
Allosteric regulation controls actin-bundling properties of human plastins.
Nature structural & molecular biology
Schwebach CL,Kudryashova E,Agrawal R,Zheng W,Egelman EH,Kudryashov DS
MA5-11869 was used in Western Blot to show that ABD2 can bind actin three orders of magnitude stronger than ABD1, unless the domains are involved in an equally strong inhibitory engagement.
Wed Jun 01 00:00:00 UTC 2022
Centromeric transcription maintains centromeric cohesion in human cells.
The Journal of cell biology
Chen Y,Zhang Q,Teng Z,Liu H
MA5-11869 was used in Western Blotting to find that several transcriptional inhibitors exhibited distinct, even opposing, efficacies on the suppression of ongoing gene and centromeric transcription in human cells, whereas under the same conditions, total centromeric RNAs were changed to a lesser extent.
Mon Jul 05 00:00:00 UTC 2021
Centromeric transcription maintains centromeric cohesion in human cells.
The Journal of cell biology
Chen Y,Zhang Q,Teng Z,Liu H
MA5-11869 was used in Western Blotting to find that several transcriptional inhibitors exhibited distinct, even opposing, efficacies on the suppression of ongoing gene and centromeric transcription in human cells, whereas under the same conditions, total centromeric RNAs were changed to a lesser extent.
Mon Jul 05 00:00:00 UTC 2021
Expression and function of the P2X7 receptor in human osteoblasts: The role of NFATc1 transcription factor.
Journal of cellular physiology
Bergamin LS,Penolazzi L,Lambertini E,Falzoni S,Sarti AC,Molle CM,Gendron FP,De Bonis P,Di Virgilio F,Piva R
Published figure using Actin monoclonal antibody (Product # MA5-11869) in Western Blot
Fri Jan 01 00:00:00 UTC 2021
The role of Mfn2 in the structure and function of endoplasmic reticulum-mitochondrial tethering in vivo.
Journal of cell science
Han S,Zhao F,Hsia J,Ma X,Liu Y,Torres S,Fujioka H,Zhu X
MA5-11869 was used in Western Blot to support the notion that Mfn2 plays a critical role in ER-mitochondrial tethering and the formation of close contacts in neuronal cells in vivo.
Thu Jul 01 00:00:00 UTC 2021
Autophagy Induction and Accumulation of Phosphorylated Tau in the Hippocampus and Prefrontal Cortex of Adult C57BL/6 Mice Subjected to Adolescent Fluoxetine Treatment.
Journal of Alzheimer's disease : JAD
Sierra-Fonseca JA,Rodriguez M,Themann A,Lira O,Flores-Ramirez FJ,Vargas-Medrano J,Gadad BS,Iñiguez SD
MA5-11869 was used in Western Blot to evaluate protein markers of autophagy (Beclin-1, LC3-II, p62) and the UPS (K48-pUb), as well as AD-associated forms of phosphorylated tau, within the hippocampus and prefrontal cortex.
Thu Dec 16 00:00:00 UTC 2021
MicroRNA-206 inhibits influenza A virus replication by targeting tankyrase 2.
Cellular microbiology
Bamunuarachchi G,Yang X,Huang C,Liang Y,Guo Y,Liu L
MA5-11869 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to indicate that miR-206 has anti-influenza activity by targeting TNKS2 and subsequently activating the anti-viral state.
Mon Feb 01 00:00:00 UTC 2021
MicroRNA-206 inhibits influenza A virus replication by targeting tankyrase 2.
Cellular microbiology
Bamunuarachchi G,Yang X,Huang C,Liang Y,Guo Y,Liu L
MA5-11869 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to indicate that miR-206 has anti-influenza activity by targeting TNKS2 and subsequently activating the anti-viral state.
Mon Feb 01 00:00:00 UTC 2021
MicroRNA-206 inhibits influenza A virus replication by targeting tankyrase 2.
Cellular microbiology
Bamunuarachchi G,Yang X,Huang C,Liang Y,Guo Y,Liu L
MA5-11869 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to indicate that miR-206 has anti-influenza activity by targeting TNKS2 and subsequently activating the anti-viral state.
Mon Feb 01 00:00:00 UTC 2021
Shigella OspC3 suppresses murine cytosolic LPS sensing.
iScience
Oh C,Verma A,Hafeez M,Hogland B,Aachoui Y
MA5-11869 was used in Western Blot to reveal that OspC3 suppresses cytosolic LPS detection in a broad array of mammals.
Fri Aug 20 00:00:00 UTC 2021
Shigella OspC3 suppresses murine cytosolic LPS sensing.
iScience
Oh C,Verma A,Hafeez M,Hogland B,Aachoui Y
MA5-11869 was used in Western Blot to reveal that OspC3 suppresses cytosolic LPS detection in a broad array of mammals.
Fri Aug 20 00:00:00 UTC 2021
CD73 Maintains Hepatocyte Metabolic Integrity and Mouse Liver Homeostasis in a Sex-Dependent Manner.
Cellular and molecular gastroenterology and hepatology
Alcedo KP,Rouse MA,Jung GS,Fu D,Minor M,Willcockson HH,Greene KG,Snider NT
MA5-11869 was used in Western Blotting to determine if CD73 has nonredundant hepatoprotective functions.
Mon Jan 24 00:00:00 UTC 2022
CD73 Maintains Hepatocyte Metabolic Integrity and Mouse Liver Homeostasis in a Sex-Dependent Manner.
Cellular and molecular gastroenterology and hepatology
Alcedo KP,Rouse MA,Jung GS,Fu D,Minor M,Willcockson HH,Greene KG,Snider NT
MA5-11869 was used in Western Blotting to determine if CD73 has nonredundant hepatoprotective functions.
Mon Jan 24 00:00:00 UTC 2022
Antibody-drug nanoparticle induces synergistic treatment efficacies in HER2 positive breast cancer cells.
Scientific reports
Abedin MR,Powers K,Aiardo R,Barua D,Barua S
MA5-11869 was used in Western Blot to engineer antibody-drug nanoparticles by synthesizing pure anti-cancer drug nanorods in the core of nanoparticles with a therapeutic monoclonal antibody.
Thu Apr 01 00:00:00 UTC 2021
Antibody-drug nanoparticle induces synergistic treatment efficacies in HER2 positive breast cancer cells.
Scientific reports
Abedin MR,Powers K,Aiardo R,Barua D,Barua S
MA5-11869 was used in Western Blot to engineer antibody-drug nanoparticles by synthesizing pure anti-cancer drug nanorods in the core of nanoparticles with a therapeutic monoclonal antibody.
Thu Apr 01 00:00:00 UTC 2021
Korean Red Ginseng Ameliorates Fatigue via Modulation of 5-HT and Corticosterone in a Sleep-Deprived Mouse Model.
Nutrients
Kang JY,Kim DY,Lee JS,Hwang SJ,Kim GH,Hyun SH,Son CG
MA5-11869 was used in Western Blotting to demonstrate the anti-fatigue effects of KRG in an SD mouse model, indicating the clinical relevance of KRG.
Mon Sep 06 00:00:00 UTC 2021
Inhibition of PCSK9 potentiates immune checkpoint therapy for cancer.
Nature
Liu X,Bao X,Hu M,Chang H,Jiao M,Cheng J,Xie L,Huang Q,Li F,Li CY
Published figure using Actin monoclonal antibody (Product # MA5-11869) in Western Blot
Tue Dec 01 00:00:00 UTC 2020
The molecular basis of tight nuclear tethering and inactivation of cGAS.
Nature
Zhao B,Xu P,Rowlett CM,Jing T,Shinde O,Lei Y,West AP,Liu WR,Li P
MA5-11869 was used in Western Blotting to show that cGAS binds to nucleosomes with nanomolar affinity and that nucleosome binding potently inhibits its catalytic activity.
Sun Nov 01 00:00:00 UTC 2020
Beclin 1 Promotes Endosome Recruitment of Hepatocyte Growth Factor Tyrosine Kinase Substrate to Suppress Tumor Proliferation.
Cancer research
Matthew-Onabanjo AN,Janusis J,Mercado-Matos J,Carlisle AE,Kim D,Levine F,Cruz-Gordillo P,Richards R,Lee MJ,Shaw LM
Published figure using Actin monoclonal antibody (Product # MA5-11869) in Western Blot
Wed Jan 15 00:00:00 UTC 2020
Intein-mediated cytoplasmic reconstitution of a split toxin enables selective cell ablation in mixed populations and tumor xenografts.
Proceedings of the National Academy of Sciences of the United States of America
Purde V,Kudryashova E,Heisler DB,Shakya R,Kudryashov DS
MA5-11869 was used in Western Blot to demonstrate delivery of split-toxin parts via specific cell-surface receptors used for specific ablation in tumour xenografts.
Tue Sep 08 00:00:00 UTC 2020
Cross-talk between Colon Cells and Macrophages Increases ST6GALNAC1 and MUC1-sTn Expression in Ulcerative Colitis and Colitis-Associated Colon Cancer.
Cancer immunology research
Kvorjak M,Ahmed Y,Miller ML,Sriram R,Coronnello C,Hashash JG,Hartman DJ,Telmer CA,Miskov-Zivanov N,Finn OJ,Cascio S
MA5-11869 was used in Western Blotting to investigate whether glycosylation of MUC1 to form MUC1 oncoproteins is influenced by macrophage-associated cytokines.
Sat Feb 01 00:00:00 UTC 2020
Cross-talk between Colon Cells and Macrophages Increases ST6GALNAC1 and MUC1-sTn Expression in Ulcerative Colitis and Colitis-Associated Colon Cancer.
Cancer immunology research
Kvorjak M,Ahmed Y,Miller ML,Sriram R,Coronnello C,Hashash JG,Hartman DJ,Telmer CA,Miskov-Zivanov N,Finn OJ,Cascio S
MA5-11869 was used in Western Blotting to investigate whether glycosylation of MUC1 to form MUC1 oncoproteins is influenced by macrophage-associated cytokines.
Sat Feb 01 00:00:00 UTC 2020
Synergistic activation of AMPK prevents from polyglutamine-induced toxicity in Caenorhabditis elegans.
Pharmacological research
Gómez-Escribano AP,Bono-Yagüe J,García-Gimeno MA,Sequedo MD,Hervás D,Fornés-Ferrer V,Torres-Sánchez SC,Millán JM,Sanz P,Vázquez-Manrique RP
MA5-11869 was used in Western Blotting to show that metformin, together with salicylate, can synergistically reduce the number of aggregates produced after polyQ expression in Caenorhabditis elegans.
Sun Nov 01 00:00:00 UTC 2020
CR4056, a powerful analgesic imidazoline-2 receptor ligand, inhibits the inflammation-induced PKCε phosphorylation and membrane translocation in sensory neurons.
British journal of pharmacology
Vellani V,Sabatini C,Milia C,Caselli G,Lanza M,Letari O,Rovati LC,Giacomoni C
MA5-11869 was used in Western Blotting to demonstrate that CR4056 shares the ability to inhibit PKCε translocation with other analgesics.
Wed Jan 01 00:00:00 UTC 2020
Epstein-Barr virus-positive gastric cancer involves enhancer activation through activating transcription factor 3.
Cancer science
Asakawa Y,Okabe A,Fukuyo M,Li W,Ikeda E,Mano Y,Funata S,Namba H,Fujii T,Kita K,Matsusaka K,Kaneda A
MA5-11869 was used in Western Blotting to investigate activation of enhancer regions and related transcription factors (TFs) that could contribute to tumorigenesis.
Fri May 01 00:00:00 UTC 2020
Biochemical study on the protective effect of curcumin on acetaminophen and gamma-irradiation induced hepatic toxicity in rats.
Environmental toxicology
Eassawy MMT,Salem AA,Ismail AFM
Published figure using Actin monoclonal antibody (Product # MA5-11869) in Western Blot
Thu Dec 17 00:00:00 UTC 2020
Multisite phosphorylation determines the formation of Ska-Ndc80 macro-complexes that are essential for chromosome segregation during mitosis.
Molecular biology of the cell
Zhang Q,Hu L,Chen Y,Tian W,Liu H
MA5-11869 was used in Western Blotting to propose that multisite Cdk1 phosphorylation is critical for the formation of Ska-Ndc80 macro-complexes that are essential for chromosome segregation.
Sat Aug 01 00:00:00 UTC 2020
Multisite phosphorylation determines the formation of Ska-Ndc80 macro-complexes that are essential for chromosome segregation during mitosis.
Molecular biology of the cell
Zhang Q,Hu L,Chen Y,Tian W,Liu H
MA5-11869 was used in Western Blotting to propose that multisite Cdk1 phosphorylation is critical for the formation of Ska-Ndc80 macro-complexes that are essential for chromosome segregation.
Sat Aug 01 00:00:00 UTC 2020
Antifungal itraconazole ameliorates experimental autoimmune encephalomyelitis through a novel mechanism of action.
Advances in clinical and experimental medicine : official organ Wroclaw Medical University
Huang H,Tian X,Peng X,Huang L,Mei L,Zhan Y,Chen S,Wu H,Wei G,Cai X
MA5-11869 was used in Western Blotting to reveal a new method for treating MS using currently approved antifungal drugs.
Fri May 01 00:00:00 UTC 2020
Neutrophil Caspase-11 Is Essential to Defend against a Cytosol-Invasive Bacterium.
Cell reports
Kovacs SB,Oh C,Maltez VI,McGlaughon BD,Verma A,Miao EA,Aachoui Y
MA5-11869 was used in Western Blot to define how caspase-1 and caspase-11 regulate destructive mechanisms against pathogens.
Tue Jul 28 00:00:00 UTC 2020
Neutrophil Caspase-11 Is Essential to Defend against a Cytosol-Invasive Bacterium.
Cell reports
Kovacs SB,Oh C,Maltez VI,McGlaughon BD,Verma A,Miao EA,Aachoui Y
MA5-11869 was used in Western Blot to define how caspase-1 and caspase-11 regulate destructive mechanisms against pathogens.
Tue Jul 28 00:00:00 UTC 2020
Aquilariae Lignum Methylene Chloride Fraction Attenuates IL-1β-Driven Neuroinflammation in BV2 Microglial Cells.
International journal of molecular sciences
Lee JS,Jeon YJ,Kang JY,Lee SK,Lee HD,Son CG
MA5-11869 was used in Western Blotting to investigate the anti-neuroinflammatory effects and underlying mechanisms of the Aquilariae Lignum fraction (ALF) using lipopolysaccharide (LPS)-stimulated BV2 microglial cells.
Thu Jul 30 00:00:00 UTC 2020
Aquilariae Lignum Methylene Chloride Fraction Attenuates IL-1β-Driven Neuroinflammation in BV2 Microglial Cells.
International journal of molecular sciences
Lee JS,Jeon YJ,Kang JY,Lee SK,Lee HD,Son CG
MA5-11869 was used in Western Blotting to investigate the anti-neuroinflammatory effects and underlying mechanisms of the Aquilariae Lignum fraction (ALF) using lipopolysaccharide (LPS)-stimulated BV2 microglial cells.
Thu Jul 30 00:00:00 UTC 2020
Berberine affects mitochondrial activity and cell growth of leukemic cells from chronic lymphocytic leukemia patients.
Scientific reports
Ravera S,Ghiotto F,Tenca C,Gugiatti E,Santamaria S,Ledda B,Ibatici A,Cutrona G,Mazzarello AN,Bagnara D,Cardillo M,Zarcone D,Darzynkiewicz Z,Ciccone E,Fais F,Bruno S
MA5-11869 was used in Western Blotting to show chronic lymphocytic leukemia cells are affected by the presence of alkaloid Berberine.
Mon Oct 05 00:00:00 UTC 2020
Berberine affects mitochondrial activity and cell growth of leukemic cells from chronic lymphocytic leukemia patients.
Scientific reports
Ravera S,Ghiotto F,Tenca C,Gugiatti E,Santamaria S,Ledda B,Ibatici A,Cutrona G,Mazzarello AN,Bagnara D,Cardillo M,Zarcone D,Darzynkiewicz Z,Ciccone E,Fais F,Bruno S
MA5-11869 was used in Western Blotting to show chronic lymphocytic leukemia cells are affected by the presence of alkaloid Berberine.
Mon Oct 05 00:00:00 UTC 2020
In utero exposure to transient ischemia-hypoxemia promotes long-term neurodevelopmental abnormalities in male rat offspring.
JCI insight
Palanisamy A,Giri T,Jiang J,Bice A,Quirk JD,Conyers SB,Maloney SE,Raghuraman N,Bauer AQ,Garbow JR,Wozniak DF
MA5-11869 was used in Western Blotting to design an aberrant uterine hypercontractility paradigm with oxytocin to better assess the consequences of acute, but transient, placental ischemia-hypoxemia in term pregnant rats.
Thu May 21 00:00:00 UTC 2020
MAGE-A3 is a prognostic biomarker for poor clinical outcome in cutaneous squamous cell carcinoma with perineural invasion via modulation of cell proliferation.
PloS one
Chen A,Santana AL,Doudican N,Roudiani N,Laursen K,Therrien JP,Lee J,Felsen D,Carucci JA
MA5-11869 was used in Western Blot to highlight the potential prognostic value of MAGE-A3 in clinical outcomes of cutaneous squamous cell carcinoma patients.
Wed Dec 23 00:00:00 UTC 2020
MAGE-A3 is a prognostic biomarker for poor clinical outcome in cutaneous squamous cell carcinoma with perineural invasion via modulation of cell proliferation.
PloS one
Chen A,Santana AL,Doudican N,Roudiani N,Laursen K,Therrien JP,Lee J,Felsen D,Carucci JA
MA5-11869 was used in Western Blot to highlight the potential prognostic value of MAGE-A3 in clinical outcomes of cutaneous squamous cell carcinoma patients.
Wed Dec 23 00:00:00 UTC 2020
18F-Fluorodeoxyglucose Positron Emission Tomography Tracks the Heterogeneous Brain Susceptibility to the Hyperglycemia-Related Redox Stress.
International journal of molecular sciences
Miceli A,Cossu V,Marini C,Castellani P,Raffa S,Donegani MI,Bruno S,Ravera S,Emionite L,Orengo AM,Grillo F,Nobili F,Morbelli S,Uccelli A,Sambuceti G,Bauckneht M
MA5-11869 was used in Western Blotting to perform dynamic positron emission tomography to clarify link between FDG uptake and activation of a specific pentose phosphate pathway (PPP), triggered by hexose-6P-dehydrogenase (H6PD) and contributing to fuel NADPH-dependent antioxidant responses in the endoplasmic reticulum (ER).
Sat Oct 31 00:00:00 UTC 2020
Interaction between the autophagy protein Beclin 1 and Na+,K+-ATPase during starvation, exercise, and ischemia.
JCI insight
Fernández ÁF,Liu Y,Ginet V,Shi M,Nah J,Zou Z,Zhou A,Posner BA,Xiao G,Tanguy M,Paradis V,Sadoshima J,Rautou PE,Puyal J,Hu MC,Levine B
MA5-11869 was used in Western Blot to explore the hypothesis that Na+,K+-ATPase interacts with the autophagy protein Beclin 1 during stress and autosis-inducing conditions.
Thu Jan 16 00:00:00 UTC 2020
Stress-induced NLRP3 inflammasome activation negatively regulates fear memory in mice.
Journal of neuroinflammation
Dong Y,Li S,Lu Y,Li X,Liao Y,Peng Z,Li Y,Hou L,Yuan Z,Cheng J
MA5-11869 was used in Western Blotting to reveal the pivotal role of NLRP3 inflammasome activation in the regulation of fear memory and the development of PTSD and anxiety disorder, providing a novel target for the clinical treatment of such disorders.
Tue Jul 07 00:00:00 UTC 2020
Stress-induced NLRP3 inflammasome activation negatively regulates fear memory in mice.
Journal of neuroinflammation
Dong Y,Li S,Lu Y,Li X,Liao Y,Peng Z,Li Y,Hou L,Yuan Z,Cheng J
MA5-11869 was used in Western Blotting to reveal the pivotal role of NLRP3 inflammasome activation in the regulation of fear memory and the development of PTSD and anxiety disorder, providing a novel target for the clinical treatment of such disorders.
Tue Jul 07 00:00:00 UTC 2020
An Adrenalectomy Mouse Model Reflecting Clinical Features for Chronic Fatigue Syndrome.
Biomolecules
Lee JS,Jeon YJ,Park SY,Son CG
MA5-11869 was used in Western Blot to compare two chronic fatigue syndrome animal models most commonly used, by injection with lipopolysaccharide (LPS from Escherichia coli O111:B4) or polyinosinic: polycytidylic acid (poly I:C), along with bilateral adrenalectomy (ADX) as another possible model.
Wed Jan 01 00:00:00 UTC 2020
A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1.
Nature
Zhao B,Du F,Xu P,Shu C,Sankaran B,Bell SL,Liu M,Lei Y,Gao X,Fu X,Zhu F,Liu Y,Laganowsky A,Zheng X,Ji JY,West AP,Watson RO,Li P
MA5-11869 was used in Western Blotting to show a conserved PLPLRT/SD motif within the C-terminal tail of STING binds to the dimer interface of TBK1.
Wed May 01 00:00:00 UTC 2019
HDAC6 dysfunction contributes to impaired maturation of adult neurogenesis in vivo: vital role on functional recovery after ischemic stroke.
Journal of biomedical science
Sheu JR,Hsieh CY,Jayakumar T,Lin GY,Lee HN,Huang SW,Yang CH
MA5-11869 was used in Western Blotting to unravel that dysfunction of HDAC6 contributes to stroke induced deficits in neurogenesis and provides an innovative therapeutic strategy that targets HDAC6 for promoting functional recovery toward the patients with stroke in clinic.
Thu Apr 18 00:00:00 UTC 2019
HDAC6 dysfunction contributes to impaired maturation of adult neurogenesis in vivo: vital role on functional recovery after ischemic stroke.
Journal of biomedical science
Sheu JR,Hsieh CY,Jayakumar T,Lin GY,Lee HN,Huang SW,Yang CH
MA5-11869 was used in Western Blotting to unravel that dysfunction of HDAC6 contributes to stroke induced deficits in neurogenesis and provides an innovative therapeutic strategy that targets HDAC6 for promoting functional recovery toward the patients with stroke in clinic.
Thu Apr 18 00:00:00 UTC 2019
Antibody-Mediated Protective Mechanisms Induced by a Trivalent Parainfluenza Virus-Vectored Ebolavirus Vaccine.
Journal of virology
Kimble JB,Malherbe DC,Meyer M,Gunn BM,Karim MM,Ilinykh PA,Iampietro M,Mohamed KS,Negi S,Gilchuk P,Huang K,Wolf YI,Braun W,Crowe JE,Alter G,Bukreyev A
MA5-11869 was used in Western Blotting to demonstrate the effect of monovalent and trivalent vaccines in protection against ebolavirus.
Fri Feb 15 00:00:00 UTC 2019
High-throughput single-molecule RNA imaging analysis reveals heterogeneous responses of cardiomyocytes to hemodynamic overload.
Journal of molecular and cellular cardiology
Satoh M,Nomura S,Harada M,Yamaguchi T,Ko T,Sumida T,Toko H,Naito AT,Takeda N,Tobita T,Fujita T,Ito M,Fujita K,Ishizuka M,Kariya T,Akazawa H,Kobayashi Y,Morita H,Takimoto E,Aburatani H,Komuro I
MA5-11869 was used in Western Blotting to study the spatial and temporal regulation of heterogenous Myh7 expression in cardiomyocytes after pressure overload.
Fri Mar 01 00:00:00 UTC 2019
Profilin and formin constitute a pacemaker system for robust actin filament growth.
eLife
Funk J,Merino F,Venkova L,Heydenreich L,Kierfeld J,Vargas P,Raunser S,Piel M,Bieling P
Published figure using Actin monoclonal antibody (Product # MA5-11869) in Western Blot
Thu Oct 24 00:00:00 UTC 2019
The Non-ureogenic Stinging Catfish, Heteropneustes fossilis, Actively Excretes Ammonia With the Help of Na+/K+-ATPase When Exposed to Environmental Ammonia.
Frontiers in physiology
Chew SF,Tan SZL,Ip SCY,Pang CZ,Hiong KC,Ip YK
Published figure using Actin monoclonal antibody (Product # MA5-11869) in Western Blot
Mon Sep 28 00:00:00 UTC 2020
Role of the P2X7 receptor in in vitro and in vivo glioma tumor growth.
Oncotarget
Bergamin LS,Capece M,Salaro E,Sarti AC,Falzoni S,Pereira MSL,De Bastiani MA,Scholl JN,Battastini AMO,Di Virgilio F
MA5-11869 was used in Western Blotting to study the role of P2X7R in glioblastoma multiforme growth.
Tue Aug 06 00:00:00 UTC 2019
Intermittent restraint-induced sympathetic activation attenuates hepatic steatosis and inflammation in a high-fat diet-fed mouse model.
American journal of physiology. Gastrointestinal and liver physiology
Lee SB,Kim HG,Lee JS,Kim WY,Lee MM,Kim YH,Lee JO,Kim HS,Son CG
MA5-11869 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to show the beneficial effects on HFD-induced hepatic steatosis and partial inflammation by intermittent restraint-induced sympathetic activation.
Sun Dec 01 00:00:00 UTC 2019
PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma.
Nature communications
Fons NR,Sundaram RK,Breuer GA,Peng S,McLean RL,Kalathil AN,Schmidt MS,Carvalho DM,Mackay A,Jones C,Carcaboso ÁM,Nazarian J,Berens ME,Brenner C,Bindra RS
MA5-11869 was used in Western Blotting to reveal a promising approach for the targeting of PPM1D mutant tumors, and define a critical link between oncogenic driver mutations and NAD metabolism, which can be exploited for tumor-specific cell killing.
Thu Aug 22 00:00:00 UTC 2019
Actin Cross-Linking Toxin Is a Universal Inhibitor of Tandem-Organized and Oligomeric G-Actin Binding Proteins.
Current biology : CB
Kudryashova E,Heisler DB,Williams B,Harker AJ,Shafer K,Quinlan ME,Kovar DR,Vavylonis D,Kudryashov DS
Mon May 21 00:00:00 UTC 2018
In Vitro Transformation of Human Bronchial Epithelial Cells by Diesel Exhaust Particles: Gene Expression Profiling and Early Toxic Responses.
Toxicological sciences : an official journal of the Society of Toxicology
Rynning I,Neca J,Vrbova K,Libalova H,Rossner P,Holme JA,Gützkow KB,Afanou AKJ,Arnoldussen YJ,Hruba E,Skare Ø,Haugen A,Topinka J,Machala M,Mollerup S
Published figure using Actin monoclonal antibody (Product # MA5-11869) in Western Blot
Thu Nov 01 00:00:00 UTC 2018
Peripheral Synthesis of an Atypical Protein Kinase C Mediates the Enhancement of Excitability and the Development of Mechanical Hyperalgesia Produced by Nerve Growth Factor.
Neuroscience
Kays J,Zhang YH,Khorodova A,Strichartz G,Nicol GD
MA5-11869 was used in Western Blotting to demonstrate that enhanced action potential firing produced by nerve growth factor was blocked by inhibitors of translation but not transcription.
Sat Feb 10 00:00:00 UTC 2018
C6orf106 is a novel inhibitor of the interferon-regulatory factor 3-dependent innate antiviral response.
The Journal of biological chemistry
Ambrose RL,Liu YC,Adams TE,Bean AGD,Stewart CR
MA5-11869 was used in Western Blot to characterize chromosome 6 ORF 106 (C6orf106) as an evolutionarily conserved inhibitor of the innate antiviral response.
Fri Jul 06 00:00:00 UTC 2018
Synthesis and anti-glioblastoma effects of artemisinin-isothiocyanate derivatives.
RSC advances
Nyein CM,Zhong X,Lu J,Luo H,Wang J,Rapposelli S,Li M,Ou-Yang Y,Pi R,He X
Published figure using Actin monoclonal antibody (Product # MA5-11869) in Western Blot
Tue Dec 04 00:00:00 UTC 2018
Newt cells secrete extracellular vesicles with therapeutic bioactivity in mammalian cardiomyocytes.
Journal of extracellular vesicles
Middleton RC,Rogers RG,De Couto G,Tseliou E,Luther K,Holewinski R,Soetkamp D,Van Eyk JE,Antes TJ,Marbán E
Published figure using Actin monoclonal antibody (Product # MA5-11869) in Western Blot
Thu Oct 01 00:00:00 UTC 2020
Early redox activities modulate Xenopus tail regeneration.
Nature communications
Ferreira F,Raghunathan V,Luxardi G,Zhu K,Zhao M
MA5-11869 was used in Western Blotting to show a mechanism for regeneration of Xenopus tails via oxygen influx, reactive oxygen species production, and HIF-1α stabilisation.
Tue Oct 16 00:00:00 UTC 2018
CDK8 mediates the dietary effects on developmental transition in Drosophila.
Developmental biology
Gao X,Xie XJ,Hsu FN,Li X,Liu M,Hemba-Waduge RU,Xu W,Ji JY
MA5-11869 was used in Western Blot to suggest that CDK8-CycC mediates the dietary effects on lipid metabolism and developmental timing in Drosophila larvae.
Sat Dec 15 00:00:00 UTC 2018
The Dynamics of mRNA Turnover Revealed by Single-Molecule Imaging in Single Cells.
Molecular cell
Horvathova I,Voigt F,Kotrys AV,Zhan Y,Artus-Revel CG,Eglinger J,Stadler MB,Giorgetti L,Chao JA
MA5-11869 was used in Western Blotting to investigate the entire life history of individual mRNAs from birth to death in single cells by use of single-molecule imaging.
Thu Nov 02 00:00:00 UTC 2017
Ska3 Phosphorylated by Cdk1 Binds Ndc80 and Recruits Ska to Kinetochores to Promote Mitotic Progression.
Current biology : CB
Zhang Q,Sivakumar S,Chen Y,Gao H,Yang L,Yuan Z,Yu H,Liu H
MA5-11869 was used in Western Blot to show that Cdk1 phosphorylates Ska3 to promote its direct binding to the Ndc80 complex (Ndc80C), a core outer kinetochore component.
Mon May 22 00:00:00 UTC 2017
TrpC5 regulates differentiation through the Ca2+/Wnt5a signalling pathway in colorectal cancer.
Clinical science (London, England : 1979)
Chen Z,Tang C,Zhu Y,Xie M,He D,Pan Q,Zhang P,Hua D,Wang T,Jin L,Qi X,Zhu Y,Yao X,Jin J,Ma X
MA511869 was used in western blot to find that TrpC5 regulates differentiation in colorectal cancer
Wed Feb 01 00:00:00 UTC 2017
Identification of a Novel Human E-Cadherin Splice Variant and Assessment of Its Effects Upon EMT-Related Events.
Journal of cellular physiology
Matos ML,Lapyckyj L,Rosso M,Besso MJ,Mencucci MV,Briggiler CI,Giustina S,Furlong LI,Vazquez-Levin MH
MA511869 was used in western blot to investigate the alternative splicing of E-cadherin mRNA
Thu Jun 01 00:00:00 UTC 2017
A novel brain tumour model in zebrafish reveals the role of YAP activation in MAPK- and PI3K-induced malignant growth.
Disease models & mechanisms
Mayrhofer M,Gourain V,Reischl M,Affaticati P,Jenett A,Joly JS,Benelli M,Demichelis F,Poliani PL,Sieger D,Mione M
MA511869 was used in western blot to propose that neurodevelopmental disorders and brain tumors may arise from changes in oncogenes
Sun Jan 01 00:00:00 UTC 2017
Rev1 contributes to proper mitochondrial function via the PARP-NAD+-SIRT1-PGC1α axis.
Scientific reports
Fakouri NB,Durhuus JA,Regnell CE,Angleys M,Desler C,Hasan-Olive MM,Martín-Pardillos A,Tsaalbi-Shtylik A,Thomsen K,Lauritzen M,Bohr VA,de Wind N,Bergersen LH,Rasmussen LJ
Published figure using Actin monoclonal antibody (Product # MA5-11869) in Western Blot
Mon Oct 02 00:00:00 UTC 2017
Poly(ADP-ribose) polymers regulate DNA topoisomerase I (Top1) nuclear dynamics and camptothecin sensitivity in living cells.
Nucleic acids research
Das SK,Rehman I,Ghosh A,Sengupta S,Majumdar P,Jana B,Das BB
MA5-11869 was used in western blot study how PARylation regulates Top1 nuclear dynamics
Fri Sep 30 00:00:00 UTC 2016
The Human Papillomavirus 16 E7 Oncoprotein Attenuates AKT Signaling To Promote Internal Ribosome Entry Site-Dependent Translation and Expression of c-MYC.
Journal of virology
Strickland SW,Vande Pol S
MA5-11869 was used in western blot to study attenuation of AKT signaling to promote internal ribosome entry site-dependent translation and expression of c-MYC by the human papillomavirus 16 E7 oncoprotein
Wed Jun 15 00:00:00 UTC 2016
Anti-infective Activity of 2-Cyano-3-Acrylamide Inhibitors with Improved Drug-Like Properties against Two Intracellular Pathogens.
Antimicrobial agents and chemotherapy
Passalacqua KD,Charbonneau ME,Donato NJ,Showalter HD,Sun D,Wen B,He M,Sun H,O'Riordan MX,Wobus CE
MA511869 was used in western blot to screen for deubiquitinase inhibitors that prevent infection of macrophages by intracellular pathogens
Fri Jul 01 00:00:00 UTC 2016
Increased caveolin-1 in intervertebral disc degeneration facilitates repair.
Arthritis research & therapy
Bach FC,Zhang Y,Miranda-Bedate A,Verdonschot LC,Bergknut N,Creemers LB,Ito K,Sakai D,Chan D,Meij BP,Tryfonidou MA
MA5-11869 was used in western blot to study how the role of increased caveolin-1 can help with repair to intervertebral disc degeneration
Thu Mar 03 00:00:00 UTC 2016
Adaptive response activated by dietary cis9, trans11 conjugated linoleic acid prevents distinct signs of gliadin-induced enteropathy in mice.
European journal of nutrition
Bergamo P,Palmieri G,Cocca E,Ferrandino I,Gogliettino M,Monaco A,Maurano F,Rossi M
MA5-11869 was used in western blot to evaluate the protective effect of dietary cis9, trans11 conjugated linoleic acid on gliadin-induced enteropathy
Tue Mar 01 00:00:00 UTC 2016
Effect of MUC1/β-catenin interaction on the tumorigenic capacity of pancreatic CD133+ cells.
Oncology letters
Sousa AM,Rei M,Freitas R,Ricardo S,Caffrey T,David L,Almeida R,Hollingsworth MA,Santos-Silva F
MA5-11869 was used in western blot to study CD133+ subpopulations in pancreatic cancer
Thu Sep 01 00:00:00 UTC 2016
Activation of PTHrP-cAMP-CREB1 signaling following p53 loss is essential for osteosarcoma initiation and maintenance.
eLife
Walia MK,Ho PM,Taylor S,Ng AJ,Gupte A,Chalk AM,Zannettino AC,Martin TJ,Walkley CR
MA5-11869 was used in western blot to investigate the PTHrP-cAMP-CREB1 axis in osteosarcoma
Tue Apr 12 00:00:00 UTC 2016
ACTIN-DIRECTED TOXIN. ACD toxin-produced actin oligomers poison formin-controlled actin polymerization.
Science (New York, N.Y.)
Heisler DB,Kudryashova E,Grinevich DO,Suarez C,Winkelman JD,Birukov KG,Kotha SR,Parinandi NL,Vavylonis D,Kovar DR,Kudryashov DS
Fri Jul 31 00:00:00 UTC 2015
CDK8-Cyclin C Mediates Nutritional Regulation of Developmental Transitions through the Ecdysone Receptor in Drosophila.
PLoS biology
Xie XJ,Hsu FN,Gao X,Xu W,Ni JQ,Xing Y,Huang L,Hsiao HC,Zheng H,Wang C,Zheng Y,Xiaoli AM,Yang F,Bondos SE,Ji JY
MA5-11869 was used in western blot to suggest that CDK8-CycC links nutrient intake to EcR activity and Drosophila development
Wed Jul 01 00:00:00 UTC 2015
CDK8-Cyclin C Mediates Nutritional Regulation of Developmental Transitions through the Ecdysone Receptor in Drosophila.
PLoS biology
Xie XJ,Hsu FN,Gao X,Xu W,Ni JQ,Xing Y,Huang L,Hsiao HC,Zheng H,Wang C,Zheng Y,Xiaoli AM,Yang F,Bondos SE,Ji JY
MA5-11869 was used in western blot to suggest that CDK8-CycC links nutrient intake to EcR activity and Drosophila development
Wed Jul 01 00:00:00 UTC 2015
Role of ADAM17 in the non-cell autonomous effects of oncogene-induced senescence.
Breast cancer research : BCR
Morancho B,Martínez-Barriocanal Á,Villanueva J,Arribas J
MA5-11869 was used in western blot to study the role of ADAM17 in cellular senescence and senescence secretome
Wed Aug 12 00:00:00 UTC 2015
Anti-fatigue effect of Myelophil in a chronic forced exercise mouse model.
European journal of pharmacology
Lee JS,Kim HG,Han JM,Kim YA,Son CG
MA5-11869 was used in western blot to assess the anti-fatigue effects of Myelophil.
Mon Oct 05 00:00:00 UTC 2015
The traditional drug Gongjin-Dan ameliorates chronic fatigue in a forced-stress mouse exercise model.
Journal of ethnopharmacology
Hong SS,Lee JY,Lee JS,Lee HW,Kim HG,Lee SK,Park BK,Son CG
MA5-11869 was used in western blot to evaluate the anti-fatigue effects of Gongjin-Dan in a chronic forced exercise mouse model
Sat Jun 20 00:00:00 UTC 2015
Effective elimination of chronic lymphocytic leukemia cells in the stromal microenvironment by a novel drug combination strategy using redox-mediated mechanisms.
Molecular medicine reports
Zhang W,Pelicano H,Yin R,Zeng J,Wen T,Ding L,Huang R
MA5-11869 was used in western blot to investigate how redox reactions affect treatment of chronic lymphocytic leukemia
Sun Nov 01 00:00:00 UTC 2015
Early decline in serum phospho-CSE1L levels in vemurafenib/sunitinib-treated melanoma and sorafenib/lapatinib-treated colorectal tumor xenografts.
Journal of translational medicine
Lee WR,Shen SC,Shih YH,Chou CL,Tseng JT,Chin SY,Liu KH,Chen YC,Jiang MC
MA5-11869 was used in western blot to discuss using serum CSE1L as a biomarker for assessing the efficacy of cancer therapy
Sat Jun 13 00:00:00 UTC 2015
ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling.
Nature communications
Goossens S,Radaelli E,Blanchet O,Durinck K,Van der Meulen J,Peirs S,Taghon T,Tremblay CS,Costa M,Farhang Ghahremani M,De Medts J,Bartunkova S,Haigh K,Schwab C,Farla N,Pieters T,Matthijssens F,Van Roy N,Best JA,Deswarte K,Bogaert P,Carmichael C,Rickard A,Suryani S,Bracken LS,Alserihi R,Canté-Barrett K,Haenebalcke L,Clappier E,Rondou P,Slowicka K,Huylebroeck D,Goldrath AW,Janzen V,McCormack MP,Lock RB,Curtis DJ,Harrison C,Berx G,Speleman F,Meijerink JP,Soulier J,Van Vlierberghe P,Haigh JJ
MA5-11869 was used in western blot to show that sustained Zeb2 expression initiates T-cell leukemia
Wed Jan 07 00:00:00 UTC 2015
Vaccine-mediated immunotherapy directed against a transcription factor driving the metastatic process.
Cancer research
Ardiani A,Gameiro SR,Palena C,Hamilton DH,Kwilas A,King TH,Schlom J,Hodge JW
MA5-11869 was used in western blot to study the ability of a vaccine targeting the Twist transcription factor to inhibit metastasis in a murine breast tumor model
Tue Apr 01 00:00:00 UTC 2014
WEE1 inhibition alleviates resistance to immune attack of tumor cells undergoing epithelial-mesenchymal transition.
Cancer research
Hamilton DH,Huang B,Fernando RI,Tsang KY,Palena C
MA5-11869 was used in western blot to study inhibition of WEE as a mechanism for overcoming immune resistance during the epithelial-to-mesenchymal transition of tumor cells
Thu May 01 00:00:00 UTC 2014
Poly (ADP-ribose) polymerase inhibitor LT-626: Sensitivity correlates with MRE11 mutations and synergizes with platinums and irinotecan in colorectal cancer cells.
Cancer letters
McPherson LA,Shen Y,Ford JM
MA5-11869 was used in western blot to study the efficacy of a PARP inhibitor in colorectal cancer and the effects of microsatellite instability, MRE11 mutation and co-treatment with platinum compounds or irinotecan
Fri Feb 28 00:00:00 UTC 2014
Progesterone receptor activation downregulates GATA3 by transcriptional repression and increased protein turnover promoting breast tumor growth.
Breast cancer research : BCR
Izzo F,Mercogliano F,Venturutti L,Tkach M,Inurrigarro G,Schillaci R,Cerchietti L,Elizalde PV,Proietti CJ
MA5-11869 was used in western blot to determine the role of progesterone receptor activation in increasing protein turnover and downregulation of GATA3 transcriptional repression which promotes breast tumor growth
Sat Dec 06 00:00:00 UTC 2014
Virus-encoded ectopic CD74 enhances poxvirus vaccine efficacy.
Immunology
Walline CC,Deffit SN,Wang N,Guindon LM,Crotzer VL,Liu J,Hollister K,Eisenlohr LC,Brutkiewicz RR,Kaplan MH,Blum JS
MA5-11869 was used in western blot to study the improved efficacy of vaccinia virus vaccines ectopically expressing CD74
Tue Apr 01 00:00:00 UTC 2014
Structure-activity relationship in the passage of different pyrrolizidine alkaloids through the gastrointestinal barrier: ABCB1 excretes heliotrine and echimidine.
Molecular nutrition & food research
Hessel S,Gottschalk C,Schumann D,These A,Preiss-Weigert A,Lampen A
MA5-11869 was used in western blot to study the the SAR of pyrrolizidine alkaloids in respect of their passage across the gastrointestinal barrier
Thu May 01 00:00:00 UTC 2014
The paracrine feedback loop between vitamin D₃ (1,25(OH)₂D₃) and PTHrP in prehypertrophic chondrocytes.
Journal of cellular physiology
Bach FC,Rutten K,Hendriks K,Riemers FM,Cornelissen P,de Bruin A,Arkesteijn GJ,Wubbolts R,Horton WA,Penning LC,Tryfonidou MA
MA5-11869 was used in western blot to investigate the relationship between vitamin D and parathyroid hormone signaling during skeletal development
Mon Dec 01 00:00:00 UTC 2014
A cardiomyocyte-specific Wdr1 knockout demonstrates essential functional roles for actin disassembly during myocardial growth and maintenance in mice.
The American journal of pathology
Yuan B,Wan P,Chu D,Nie J,Cao Y,Luo W,Lu S,Chen J,Yang Z
MA5-11869 was used in western blot to investigate the role of Wdr1 in actin dynamics
Tue Jul 01 00:00:00 UTC 2014
Inhibition of gamma-secretase activity impedes uterine serous carcinoma growth in a human xenograft model.
Gynecologic oncology
Groeneweg JW,Hall TR,Zhang L,Kim M,Byron VF,Tambouret R,Sathayanrayanan S,Foster R,Rueda BR,Growdon WB
MA5-11869 was used in western blot the study the inhibition of growth of a xenograft model of uterine serous carcinoma following treatment with a gamma-secretase inhibitor
Sun Jun 01 00:00:00 UTC 2014
Altered migratory behavior of interneurons in a model of cortical dysplasia: the influence of elevated GABAA activity.
Cerebral cortex (New York, N.Y. : 1991)
Abbah J,Juliano SL
MA5-11869 was used in western blot to study the role of GABA-A in the impaired migration of interneurons in a ferret model of cortical dysplasia
Mon Sep 01 00:00:00 UTC 2014
Prenatal corticosterone and adolescent URB597 administration modulate emotionality and CB1 receptor expression in mice.
Psychopharmacology
Ceci C,Mela V,Macrì S,Marco EM,Viveros MP,Laviola G
MA5-11869 was used in western blot to study the effects of prenatal stress followed by pharmacological enhancement of endocannabinoid signaling in adolescence on murine CB1 receptor expression and emotional responses
Thu May 01 00:00:00 UTC 2014
Active elimination of the marine biotoxin okadaic acid by P-glycoprotein through an in vitro gastrointestinal barrier.
Toxicology letters
Ehlers A,These A,Hessel S,Preiss-Weigert A,Lampen A
MA5-11869 was used in western blot to study the ability of P-glycoprotein to actively eliminate non-cytotoxic concentrations of okadaic acid through an in vitro gastrointestinal barrier
Mon Mar 03 00:00:00 UTC 2014
A phase II study of the EGFR inhibitor gefitinib in patients with acute myeloid leukemia.
Leukemia research
Deangelo DJ,Neuberg D,Amrein PC,Berchuck J,Wadleigh M,Sirulnik LA,Galinsky I,Golub T,Stegmaier K,Stone RM
MA5-11869 was used in western blot to perform a phase II clinical trial of gefitinib in acute myeloid leukemia patients
Tue Apr 01 00:00:00 UTC 2014
eRapa restores a normal life span in a FAP mouse model.
Cancer prevention research (Philadelphia, Pa.)
Hasty P,Livi CB,Dodds SG,Jones D,Strong R,Javors M,Fischer KE,Sloane L,Murthy K,Hubbard G,Sun L,Hurez V,Curiel TJ,Sharp ZD
MA5-11869 was used in western blot to test if enterically targeted rapamycin prevents neoplasia and extends survival of cancer prone Apc(Min/+) mice
Wed Jan 01 00:00:00 UTC 2014
A developmental genetic analysis of the lysine demethylase KDM2 mutations in Drosophila melanogaster.
Mechanisms of development
Zheng Y,Hsu FN,Xu W,Xie XJ,Ren X,Gao X,Ni JQ,Ji JY
MA5-11869 was used in western blot to study the role of Histone lysine demethylase 2 (KDM2) in Drosophila development
Fri Aug 01 00:00:00 UTC 2014
The elimination of miR-23a in heat-stressed cells promotes NOXA-induced cell death and is prevented by HSP70.
Cell death & disease
Roufayel R,Johnston DS,Mosser DD
MA5-11869 was used in western blot to examine the effects of miR-23a in cell death
Thu Nov 27 00:00:00 UTC 2014
Hematopoietic overexpression of FOG1 does not affect B-cells but reduces the number of circulating eosinophils.
PloS one
Du Roure C,Versavel A,Doll T,Cao C,Pillonel V,Matthias G,Kaller M,Spetz JF,Kopp P,Kohler H,Müller M,Matthias P
MA5-11869 was used in western blot to study the reduction in circulating eosinophil numbers in response to hematopoietic overexpression of FOG-1 in a transgenic murine model
Thu Jan 15 00:00:00 UTC 2015
Mitogen-activated protein kinase-mediated licensing of interferon regulatory factor 3/7 reinforces the cell response to virus.
The Journal of biological chemistry
Schmid S,Sachs D,tenOever BR
MA5-11869 was used in western blot to study the reinforcement of cellular responses to viral infection mediated by IFR3 and IRF7 and the role played by MAPK
Fri Jan 03 00:00:00 UTC 2014
Ligand-independent canonical Wnt activity in canine mammary tumor cell lines associated with aberrant LEF1 expression.
PloS one
Gracanin A,Timmermans-Sprang EP,van Wolferen ME,Rao NA,Grizelj J,Vince S,Hellmen E,Mol JA
MA5-11869 was used in western blot to analyze divergent LEF1 expression in ligand-independent canonical Wnt activity in canine mammary tumor cell lines
Tue Jan 20 00:00:00 UTC 2015
The prostate cancer TMPRSS2:ERG fusion synergizes with the vitamin D receptor (VDR) to induce CYP24A1 expression-limiting VDR signaling.
Endocrinology
Kim JS,Roberts JM,Bingman WE,Shao L,Wang J,Ittmann MM,Weigel NL
MA5-11869 was used in Western Blot to suggest that patients with TMPRSS2:ETS negative tumors may be more responsive to VDR-mediated growth inhibition and that TMPRSS2:ETS status should be considered in future clinical trials.
Mon Sep 01 00:00:00 UTC 2014
Contrasting expression patterns of histone mRNA and microRNA 760 in patients with gastric cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research
Iwaya T,Fukagawa T,Suzuki Y,Takahashi Y,Sawada G,Ishibashi M,Kurashige J,Sudo T,Tanaka F,Shibata K,Endo F,Katagiri H,Ishida K,Kume K,Nishizuka S,Iinuma H,Wakabayashi G,Mori M,Sasako M,Mimori K
MA5-11869 was used in western blot to study the upregulation of histone mRNA and downregulation of miRNA-760 in gastric cancer patients
Sun Dec 01 00:00:00 UTC 2013
The human Lgl polarity gene, Hugl-2, induces MET and suppresses Snail tumorigenesis.
Oncogene
Kashyap A,Zimmerman T,Ergül N,Bosserhoff A,Hartman U,Alla V,Bataille F,Galle PR,Strand S,Strand D
MA5-11869 was used in western blot to study the mechanism by which the human Hugl-2 gene suppresses Snail-induced tumorigenesis
Thu Mar 14 00:00:00 UTC 2013
Bone morphogenetic protein 4 promotes mammalian oogonial stem cell differentiation via Smad1/5/8 signaling.
Fertility and sterility
Park ES,Woods DC,Tilly JL
MA5-11869 was used in western blot to study the role of Smad signaling in the mechanism by which BMP-4 induces the differentiation of murine oogonial stem cells
Fri Nov 01 00:00:00 UTC 2013
Organotypic brain slices: a model to study the neurovascular unit micro-environment in epilepsies.
Fluids and barriers of the CNS
Morin-Brureau M,De Bock F,Lerner-Natoli M
MA5-11869 was used in western blot to develop an organotypic brain slice culture as a model to study the role of the neurovascular unit in epilepsy and other neurological disorders
Thu Feb 07 00:00:00 UTC 2013
Multidrug resistance-associated proteins are involved in the transport of the glutathione conjugates of the ultimate carcinogen of benzo[a]pyrene in human Caco-2 cells.
Archives of toxicology
Hessel S,John A,Seidel A,Lampen A
MA5-11869 was used in western blot to study the role of multi-drug resistance proteins in the excretion by Caco-2 cells of gluthathione conjugates of the ultimate carcinogen of benzo[a]pyrene
Fri Feb 01 00:00:00 UTC 2013
Caspase-2 mediates a Brucella abortus RB51-induced hybrid cell death having features of apoptosis and pyroptosis.
Frontiers in cellular and infection microbiology
Bronner DN,O'Riordan MX,He Y
MA5-11869 was used in western blot to investigate the role of caspase-2 in programed cell death during infection with Brucella abortus
Mon Apr 21 00:00:00 UTC 2014
Coordinate regulation of N-glycosylation gene DPAGT1, canonical Wnt signaling and E-cadherin adhesion.
Journal of cell science
Sengupta PK,Bouchie MP,Nita-Lazar M,Yang HY,Kukuruzinska MA
MA5-11869 was used in western blot to study the roles of Wnt and E-cadherin in the coordinate regulation of N-glycosylation and DPAGT1 expression
Tue Jan 15 00:00:00 UTC 2013
Galectin-7 and actin are components of amyloid deposit of localized cutaneous amyloidosis.
Experimental dermatology
Miura Y,Harumiya S,Ono K,Fujimoto E,Akiyama M,Fujii N,Kawano H,Wachi H,Tajima S
MA5-11869 was used in western blot to study the presence of galectin-7 and actin in amyloid deposits from localized cutaneous amyloidosis lesions asociated with Bowen's disease
Tue Jan 01 00:00:00 UTC 2013
Senescent human periodontal ligament fibroblasts after replicative exhaustion or ionizing radiation have a decreased capacity towards osteoblastic differentiation.
Biogerontology
Konstantonis D,Papadopoulou A,Makou M,Eliades T,Basdra EK,Kletsas D
MA5-11869 was used in western blot to study the reduced osteoblastic differentiation capability of human peridontal ligament fibroblasts that have become senescent due to replicative exhaustion or ionizing irradiation
Sun Dec 01 00:00:00 UTC 2013
Subtotal nephrectomy accelerates pathological cardiac remodeling post-myocardial infarction: implications for cardiorenal syndrome.
International journal of cardiology
Liu S,Kompa AR,Kumfu S,Nishijima F,Kelly DJ,Krum H,Wang BH
MA5-11869 was used in western blot to study the changes in kidney and liver function in response to partial nephrectomy after myocardial infarction
Thu Oct 03 00:00:00 UTC 2013
Preference toward a polylysine enantiomer in inhibiting prions.
Amino acids
Jackson KS,Yeom J,Han Y,Bae Y,Ryou C
MA5-11869 was used in western blot to study the relative ability of poly-L-lysine and poly-D-lysine to inhibit prions
Fri Mar 01 00:00:00 UTC 2013
Heat-shock factor 1 both positively and negatively affects cellular clonogenic growth depending on p53 status.
The Biochemical journal
Nguyen CH,Lang BJ,Chai RC,Vieusseux JL,Kouspou MM,Price JT
MA5-11869 was used in western blot to study the effects of p53 status on the modulation of clonogenic cellular growth by HSF-1
Sat Jun 01 00:00:00 UTC 2013
Human folliculin delays cell cycle progression through late S and G2/M-phases: effect of phosphorylation and tumor associated mutations.
PloS one
Laviolette LA,Wilson J,Koller J,Neil C,Hulick P,Rejtar T,Karger B,Teh BT,Iliopoulos O
MA5-11869 was used in western blot to study the effects of phosphorylation and cancer-associated mutations on the cell-cycle delaying activity of human folliculin
Thu Apr 17 00:00:00 UTC 2014
Cofactor balance by nicotinamide nucleotide transhydrogenase (NNT) coordinates reductive carboxylation and glucose catabolism in the tricarboxylic acid (TCA) cycle.
The Journal of biological chemistry
Gameiro PA,Laviolette LA,Kelleher JK,Iliopoulos O,Stephanopoulos G
MA5-11869 was used in western blot to study the role of nicotinamide nucleotide transhydrogenase in modulating carbon metabolism within the TCA cycle
Fri May 03 00:00:00 UTC 2013
Properties and expression of Na+/K+-ATPase α-subunit isoforms in the brain of the swamp eel, Monopterus albus, which has unusually high brain ammonia tolerance.
PloS one
Chen XL,Wee NL,Hiong KC,Ong JL,Chng YR,Ching B,Wong WP,Chew SF,Ip YK
MA5-11869 was used in western blot to study the effects of exposure to ammonia on the expression of swamp eel brain Na(+), K(+)-ATPase alpha subunits and the significance for the very high brain ammonia tolerance of this organism
Tue Sep 02 00:00:00 UTC 2014
Proprotein convertase 1/3 (PC1/3) in the rat alveolar macrophage cell line NR8383: localization, trafficking and effects on cytokine secretion.
PloS one
Gagnon H,Refaie S,Gagnon S,Desjardins R,Salzet M,Day R
MA5-11869 was used in western blot to study the expression of proprotein convertase 1/3 in a alveolar macrophage cell line and its role in vessicle trafficking and cytokine secretion
Mon Dec 09 00:00:00 UTC 2013
Toxoplasma gondii inhibits mast cell degranulation by suppressing phospholipase Cγ-mediated Ca(2+) mobilization.
Frontiers in microbiology
Smith NL,Abi Abdallah DS,Butcher BA,Denkers EY,Baird B,Holowka D
MA5-11869 was used in western blot to study the role of phospholipase C-gamma-mediated Ca(2+) flux in the mechanism by which Toxoplasma gondii inhibits the degranulation of mast cells
Fri Jul 12 00:00:00 UTC 2013
The uremic toxin adsorbent AST-120 abrogates cardiorenal injury following myocardial infarction.
PloS one
Lekawanvijit S,Kumfu S,Wang BH,Manabe M,Nishijima F,Kelly DJ,Krum H,Kompa AR
MA5-11869 was used in western blot to study the ability of an oral adsorbent of indoxyl sulfate to protect against myocardial infarction-induced cardio-renal injury in a rat model
Mon Sep 29 00:00:00 UTC 2014
Tanshinone IIA increases the bystander effect of herpes simplex virus thymidine kinase/ganciclovir gene therapy via enhanced gap junctional intercellular communication.
PloS one
Xiao J,Zhang G,Qiu P,Liu X,Wu Y,Du B,Li J,Zhou J,Li J,Tan Y
MA5-11869 was used in western blot to study the role of improved intercellular gap junction communication in the mechanism by which tanshinone IIA enhances the bystander effect during HSV-thymidine kinase/ganciclovire gene therapy
Mon Feb 03 00:00:00 UTC 2014
FAM83B-mediated activation of PI3K/AKT and MAPK signaling cooperates to promote epithelial cell transformation and resistance to targeted therapies.
Oncotarget
Cipriano R,Miskimen KL,Bryson BL,Foy CR,Bartel CA,Jackson MW
MA5-11869 was used in western blot to study the role of FAM83B as a novel oncogene that interacts with and activates PI3 kinase/Akt and MAPK signaling pathways promoting therapeutic resistance
Wed May 01 00:00:00 UTC 2013
Radiation therapy-induced tumor invasiveness is associated with SDF-1-regulated macrophage mobilization and vasculogenesis.
PloS one
Wang SC,Yu CF,Hong JH,Tsai CS,Chiang CS
MA5-11869 was used in western blot to study the role of SDF-1-modulated macrophage activity in tumor invasivness induced by radiation therapy
Wed Mar 05 00:00:00 UTC 2014
High brain ammonia tolerance and down-regulation of Na+:K+:2Cl(-) Cotransporter 1b mRNA and protein expression in the brain of the Swamp Eel, Monopterus albus, exposed to environmental ammonia or terrestrial conditions.
PloS one
Ip YK,Hou Z,Chen XL,Ong JL,Chng YR,Ching B,Hiong KC,Chew SF
MA5-11869 was used in western blot to study the role of NKCC1 downregulation in the brain of the Swamp eel on exposure to ammonia or terrestrial conditions in the high brain ammonia tolerence of this animal
Mon Apr 28 00:00:00 UTC 2014
RedOx status, proteasome and APEH: insights into anticancer mechanisms of t10,c12-conjugated linoleic acid isomer on A375 melanoma cells.
PloS one
Bergamo P,Cocca E,Palumbo R,Gogliettino M,Rossi M,Palmieri G
MA5-11869 was used in western blot to study the molecular mechanisms underlying the anti-melanoma effects of a conjugated linoleic acid isomer
Mon Jun 30 00:00:00 UTC 2014
Enterocyte-specific inactivation of SIRT1 reduces tumor load in the APC(+/min) mouse model.
PloS one
Leko V,Park GJ,Lao U,Simon JA,Bedalov A
MA5-11869 was used in western blot to study the tumorigenic role of SIRT1 in a murine model of intestinal tumorigenesis
Thu Jan 30 00:00:00 UTC 2014
Agonist-dependent signaling by group I metabotropic glutamate receptors is regulated by association with lipid domains.
The Journal of biological chemistry
Kumari R,Castillo C,Francesconi A
MA5-11869 was used in western blot to study association of mGluR1 with lipid rafts and the role in modulating agonist-mediated signaling
Fri Nov 01 00:00:00 UTC 2013
Degradation of host microRNAs by poxvirus poly(A) polymerase reveals terminal RNA methylation as a protective antiviral mechanism.
Cell host & microbe
Backes S,Shapiro JS,Sabin LR,Pham AM,Reyes I,Moss B,Cherry S,tenOever BR
MA5-11869 was used in western blot to study the ability of poxvirus poly(A) polymerase to degrade host microRNAs and the protective effect of microRNA 2'-O-methylation
Thu Aug 16 00:00:00 UTC 2012
Partial complementation of a DNA ligase I deficiency by DNA ligase III and its impact on cell survival and telomere stability in mammalian cells.
Cellular and molecular life sciences : CMLS
Le Chalony C,Hoffschir F,Gauthier LR,Gross J,Biard DS,Boussin FD,Pennaneach V
MA5-11869 was used in western blot to study the partial complementation of DNA ligase I deficiency by DNA ligase III in mammalian cells
Sat Sep 01 00:00:00 UTC 2012
Androgen-regulated miR-32 targets BTG2 and is overexpressed in castration-resistant prostate cancer.
Oncogene
Jalava SE,Urbanucci A,Latonen L,Waltering KK,Sahu B,Jänne OA,Seppälä J,Lähdesmäki H,Tammela TL,Visakorpi T
MA5-11869 was used in western blot to characterize androgen-regulated microRNAs in castration-resistant prostate cancer
Thu Oct 11 00:00:00 UTC 2012
MicroRNA miR-146a is induced by HTLV-1 tax and increases the growth of HTLV-1-infected T-cells.
International journal of cancer
Tomita M,Tanaka Y,Mori N
MA5-11869 was used in western blot to study the role of miR-146a in the growth of HTLV-1-infected T-cells and the therapeutic significance for adult T-cell leukemia
Tue May 15 00:00:00 UTC 2012
Pharmacologic downregulation of c-FLIP(L) restores juxtacrine death receptor-mediated apoptosis in cancer cells in a peritoneal carcinomatosis model.
International journal of cancer
Shen Y,Herde R,Doxey BW,Xu C,Gray PD,Kuwada SK
MA5-11869 was used in western blot to study the effect of pharmacologically-mediated restoration of death receptor signaling on cancer cell apoptosis and implantation
Sun Apr 01 00:00:00 UTC 2012
Cell movements of the deep layer of non-neural ectoderm underlie complete neural tube closure in Xenopus.
Development (Cambridge, England)
Morita H,Kajiura-Kobayashi H,Takagi C,Yamamoto TS,Nonaka S,Ueno N
MA5-11869 was used in western blot to study the cellular and molecular mechanisms underlying the role of non-neural ectoderm in Xenopus complete neural tube closure
Sun Apr 01 00:00:00 UTC 2012
Quantification of dystrophin immunofluorescence in dystrophinopathy muscle specimens.
Neuropathology and applied neurobiology
Taylor LE,Kaminoh YJ,Rodesch CK,Flanigan KM
MA5-11869 was used in western blot to develop an immunofluorescence method for measuring low levels of dystrophin in muscle samples from dystrinopathy patients
Mon Oct 01 00:00:00 UTC 2012
Advanced glycation end-products induce calpain-mediated degradation of ezrin.
The FEBS journal
McRobert EA,Young AN,Bach LA
MA5-11869 was used in western blot to study the induction of calpain-mediated ezrin proteolysis by advanced glycation endproducts
Sat Sep 01 00:00:00 UTC 2012
Tumor-secreted SDF-1 promotes glioma invasiveness and TAM tropism toward hypoxia in a murine astrocytoma model.
Laboratory investigation; a journal of technical methods and pathology
Wang SC,Hong JH,Hsueh C,Chiang CS
MA5-11869 was used in western blot to study the effects of SDF-1 secreted by tumors on glioma invasiveness and tumor-associated macrophage behaviour in a novel murine model
Sun Jan 01 00:00:00 UTC 2012
Myocardial infarction impairs renal function, induces renal interstitial fibrosis, and increases renal KIM-1 expression: implications for cardiorenal syndrome.
American journal of physiology. Heart and circulatory physiology
Lekawanvijit S,Kompa AR,Zhang Y,Wang BH,Kelly DJ,Krum H
MA5-11869 was used in western blot to study the effects of myocardial infarction on kidney function, fibrosis and KIM-1 expression in a rat model
Tue May 01 00:00:00 UTC 2012
Functional evaluation of BRCA2 variants mapping to the PALB2-binding and C-terminal DNA-binding domains using a mouse ES cell-based assay.
Human molecular genetics
Biswas K,Das R,Eggington JM,Qiao H,North SL,Stauffer S,Burkett SS,Martin BK,Southon E,Sizemore SC,Pruss D,Bowles KR,Roa BB,Hunter N,Tessarollo L,Wenstrup RJ,Byrd RA,Sharan SK
MA5-11869 was used in western blot to study the function of BRCA2 variants using a mouse embryonic stem cell-based assay
Sat Sep 15 00:00:00 UTC 2012
CD24 is expressed in gastric parietal cells and regulates apoptosis and the response to Helicobacter felis infection in the murine stomach.
American journal of physiology. Gastrointestinal and liver physiology
Duckworth CA,Clyde D,Pritchard DM
MA5-11869 was used in western blot to study the role of gastric parietal cell CD24 and its role in regulating apoptosis and infection of the mouse stomach by Helicobacter felix
Mon Oct 15 00:00:00 UTC 2012
Strategic combination therapy overcomes tyrosine kinase coactivation in adrenocortical carcinoma.
Surgery
Lin CI,Whang EE,Moalem J,Ruan DT
MA5-11869 was used in western blot to study whether combination therapy designed to prevent receptor tyrosine kinase coactivation is of therapeutic potential in adrencortical carcinoma
Sat Dec 01 00:00:00 UTC 2012
Heat stress induces epithelial plasticity and cell migration independent of heat shock factor 1.
Cell stress & chaperones
Lang BJ,Nguyen L,Nguyen HC,Vieusseux JL,Chai RC,Christophi C,Fifis T,Kouspou MM,Price JT
MA5-11869 was used in western blot to study HSF-1-independent modulation of epithelial cell plasticity and migration by heat stress
Thu Nov 01 00:00:00 UTC 2012
Using soybean trypsin inhibitor as an external loading control for Western blot analysis of tear proteins: application to corneal disease.
Experimental eye research
You J,Hodge C,Wen L,McAvoy JW,Madigan MC,Sutton G
MA5-11869 was used in western blot to study the use of soybean trypsin inhibitor as a loading control for Western blot analysis of tear proteins
Fri Jun 01 00:00:00 UTC 2012
The human papillomavirus type 16 E7 oncoprotein targets Myc-interacting zinc-finger protein-1.
Virology
Morandell D,Kaiser A,Herold S,Rostek U,Lechner S,Mitterberger MC,Jansen-Dürr P,Eilers M,Zwerschke W
MA5-11869 was used in western blot to elucidate the gene target of HPV-16 E7 oncoprotein
Fri Jan 20 00:00:00 UTC 2012
PER1 modulates SGLT1 transcription in vitro independent of E-box status.
Digestive diseases and sciences
Balakrishnan A,Stearns AT,Ashley SW,Rhoads DB,Tavakkolizadeh A
MA5-11869 was used in western blot to study the effects of the clock gene PER1 on SGLT1 transcription
Fri Jun 01 00:00:00 UTC 2012
Influence of conformationally restricted pyrimidines on the activity of 10-23 DNAzymes.
Bioorganic & medicinal chemistry
Robaldo L,Izzo F,Dellafiore M,Proietti C,Elizalde PV,Montserrat JM,Iribarren AM
MA5-11869 was used in western blot to study the kinetic effects of modifying the catalytic core of 10-23 DNAzymes with conformationally restricted pyrimidines
Sun Apr 15 00:00:00 UTC 2012
Induction of apoptosis in Eμ-myc lymphoma cells in vitro and in vivo through calpain inhibition.
Experimental hematology
Li H,Nepal RM,Martin A,Berger SA
MA5-11869 was used in western blot to study the ability of calpain inhibition to induce apoptosis in E_-myc lymphoma cells
Sun Jul 01 00:00:00 UTC 2012
Overexpression of LAPTM4B-35 is associated with poor prognosis in colorectal carcinoma.
American journal of surgery
Kang Y,Yin M,Jiang W,Zhang H,Xia B,Xue Y,Huang Y
MA5-11869 was used in western blot to study the prognostic value of LAPTM4B-35 expression in colorectal cancer
Thu Nov 01 00:00:00 UTC 2012
Involvement of Rho kinase (ROCK) in sepsis-induced acute lung injury.
Journal of thoracic disease
Cinel I,Ark M,Dellinger P,Karabacak T,Tamer L,Cinel L,Michael P,Hussein S,Parrillo JE,Kumar A,Kumar A
MA5-11869 was used in western blot to studty the effect of a selective Rho kinase inhibitor on sepsis-induced acute lung injury
Wed Feb 01 00:00:00 UTC 2012
Effect of different durations of overdistention on rat bladder function and morphology.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
Jin XD,Cao M,Zhou XL,Yin HP,Chen ZD,Xu N,Jiang H
MA5-11869 was used in western blot to study changes in urinary bladder function and morphology following different periods of overdistension and the molecular mechanisms involved
Mon Oct 01 00:00:00 UTC 2012
Upregulation of heparanase in high-glucose-treated endothelial cells promotes endothelial cell migration and proliferation and correlates with Akt and extracellular-signal-regulated kinase phosphorylation.
Molecular vision
Yuan L,Hu J,Luo Y,Liu Q,Li T,Parish CR,Freeman C,Zhu X,Ma W,Hu X,Yu H,Tang S
MA5-11869 was used in western blot to study the effects of high glucose concentrations on heparanase expression, cell migration and proliferation in human retinal vascular endothelial cells
Tue Nov 13 00:00:00 UTC 2012
Chronic kidney disease-induced cardiac fibrosis is ameliorated by reducing circulating levels of a non-dialysable uremic toxin, indoxyl sulfate.
PloS one
Lekawanvijit S,Kompa AR,Manabe M,Wang BH,Langham RG,Nishijima F,Kelly DJ,Krum H
MA5-11869 was used in western blot to study whether reducing levels of indoxyl sulfate is protective against cardiac fibrosis in a rat model of chronic kidney disease
Fri Dec 07 00:00:00 UTC 2012
Caloric restriction reduced 1, 2-dimethylhydrazine-induced aberrant crypt foci and induces the expression of Sirtuins in colonic mucosa of F344 rats.
Journal of carcinogenesis
Tomita M
MA5-11869 was used in western blot to study the effect of caloric restriction on preneoplastic aberrant colonic crypt foci and the potential involvement of Sirtuins
Fri Aug 24 00:00:00 UTC 2012
Loss of deacetylation activity of Hdac6 affects emotional behavior in mice.
PloS one
Fukada M,Hanai A,Nakayama A,Suzuki T,Miyata N,Rodriguiz RM,Wetsel WC,Yao TP,Kawaguchi Y
MA5-11869 was used in western blot to study the modulation of murine emotional behaviour by HDAC6
Mon Jun 11 00:00:00 UTC 2012
Oncogenic Ras abrogates MEK SUMOylation that suppresses the ERK pathway and cell transformation.
Nature cell biology
Kubota Y,O'Grady P,Saito H,Takekawa M
MA5-11869 was used in western blot to study the mechanism by which oncogenic Ras activates the ERK pathway and promotes carcinogenesis
Tue Mar 01 00:00:00 UTC 2011
A comprehensive functional characterization of BRCA2 variants associated with Fanconi anemia using mouse ES cell-based assay.
Blood
Biswas K,Das R,Alter BP,Kuznetsov SG,Stauffer S,North SL,Burkett S,Brody LC,Meyer S,Byrd RA,Sharan SK
MA5-11869 was used in western blot to study the function of Fanconi anemia-associated BRCA2 variants in a murine embryonic stem cell assay
Thu Sep 01 00:00:00 UTC 2011
Fibrinogen-γ proteolysis and solubility dynamics during apoptotic mouse liver injury: heparin prevents and treats liver damage.
Hepatology (Baltimore, Md.)
Weerasinghe SV,Moons DS,Altshuler PJ,Shah YM,Omary MB
MA5-11869 was used in western blot to study fibrinogen-gamma proteolysis in apoptotic liver injury in mouse and the potential therapeutic effect of heparin treatment
Fri Apr 01 00:00:00 UTC 2011
c-MYC functions as a molecular switch to alter the response of human mammary epithelial cells to oncostatin M.
Cancer research
Kan CE,Cipriano R,Jackson MW
MA5-11869 was used in western blot to study the role of c-Myc in modulating the tumor suppressive/tumor promoting effects of oncostatin M on human mammary epithelial cells
Tue Nov 15 00:00:00 UTC 2011
Absence of keratin 8 confers a paradoxical microflora-dependent resistance to apoptosis in the colon.
Proceedings of the National Academy of Sciences of the United States of America
Habtezion A,Toivola DM,Asghar MN,Kronmal GS,Brooks JD,Butcher EC,Omary MB
MA5-11869 was used in western blot to study the microflora-dependent resistance to apoptosis of the colon in keratin-8-null mice
Tue Jan 25 00:00:00 UTC 2011
Mitogen-inducible gene-6 is a multifunctional adaptor protein with tumor suppressor-like activity in papillary thyroid cancer.
The Journal of clinical endocrinology and metabolism
Lin CI,Du J,Shen WT,Whang EE,Donner DB,Griff N,He F,Moore FD,Clark OH,Ruan DT
MA5-11869 was used in western blot to investigate the function of mitogen-inducible gene-6 Mig-6 in papillary thyroid cancer
Tue Mar 01 00:00:00 UTC 2011
ABC50 modulates sensitivity of HL60 leukemic cells to endoplasmic reticulum (ER) stress-induced cell death.
Biochemical pharmacology
Yu Y,Zhang Y,Zhu Z,Berger SA
MA5-11869 was used in western blot to study the role of ABC50 in modulating the sensitivity of HL60 leukemic cells to endoplasmic reticulum stress-induced cell death
Tue Feb 15 00:00:00 UTC 2011
Effects of hippuristanol, an inhibitor of eIF4A, on adult T-cell leukemia.
Biochemical pharmacology
Tsumuraya T,Ishikawa C,Machijima Y,Nakachi S,Senba M,Tanaka J,Mori N
MA5-11869 was used in western blot to study the ability of hippuristanol to inhibit the proliferation of HTLV-1-infected T-cells and the molecular mechanisms involved
Tue Mar 15 00:00:00 UTC 2011
Analysis of the role of IL-21 in development of murine B cell progenitors in the bone marrow.
Journal of immunology (Baltimore, Md. : 1950)
Simard N,Konforte D,Tran AH,Esufali J,Leonard WJ,Paige CJ
MA5-11869 was used in western blot to study the role of IL-21 and IL-21R in the development of murine bone marrow B cell progenitors
Sun May 01 00:00:00 UTC 2011
Overexpression of HSP70 inhibits cofilin phosphorylation and promotes lymphocyte migration in heat-stressed cells.
Journal of cell science
Simard JP,Reynolds DN,Kraguljac AP,Smith GS,Mosser DD
MA5-11869 was used in western blot to study the roles of HSP70 and cofilin in the response of lymphocytes to heat-stress
Fri Jul 15 00:00:00 UTC 2011
A DNA-dependent stress response involving DNA-PK occurs in hypoxic cells and contributes to cellular adaptation to hypoxia.
Journal of cell science
Bouquet F,Ousset M,Biard D,Fallone F,Dauvillier S,Frit P,Salles B,Muller C
MA5-11869 was used in western blot to study a DNA-dependent stress response involving DNA-PK in hypoxic cells that contributes to cellular adaptation to hypoxia
Wed Jun 01 00:00:00 UTC 2011
CARHSP1 is required for effective tumor necrosis factor alpha mRNA stabilization and localizes to processing bodies and exosomes.
Molecular and cellular biology
Pfeiffer JR,McAvoy BL,Fecteau RE,Deleault KM,Brooks SA
MA5-11869 was used in western blot to study the subcellular localization of CARHSP1 and its role in stabilizing TNFalpha mRNA
Sat Jan 01 00:00:00 UTC 2011
TNF-α-decreased thrombomodulin expression in monocytes is inhibited by propofol through regulation of tristetraprolin and human antigen R activities.
Shock (Augusta, Ga.)
Lin FY,Tsai YT,Lee CY,Lin CY,Lin YW,Li CY,Shih CM,Huang CY,Chang NC,Tsai JC,Chen TL,Tsai CS
MA5-11869 was used in western blot to study the effect of propofol on thrombomodulin expression in TNF-alpha-stimulated monocytes
Thu Sep 01 00:00:00 UTC 2011
Combining anticancer agents photodynamic therapy and LCL85 leads to distinct changes in the sphingolipid profile, autophagy, caspase-3 activation in the absence of cell death, and long-term sensitization.
Biochemical and biophysical research communications
Separovic D,Joseph N,Breen P,Bielawski J,Pierce JS,Buren EV,Bhatti G,Saad ZH,Bai A,Bielawska A
MA5-11869 was used in western blot to study the effects of a combination of photodynamic therapy and LCL85 on sphingolipids and cell death
Fri Jun 10 00:00:00 UTC 2011
Apoptosis-inducing factor contributes to epithelial cell apoptosis induced by enteropathogenic Escherichia coli.
Canadian journal of physiology and pharmacology
Flynn AN,Wang A,McKay DM,Buret AG
MA5-11869 was used in western blot to study the role of AIF in the induction of epithelial cell apoptosis by enteropathogenic Escherichia coli
Tue Feb 01 00:00:00 UTC 2011
Subtype specific elevated expression of hyaluronidase-1 (HYAL-1) in epithelial ovarian cancer.
PloS one
Yoffou PH,Edjekouane L,Meunier L,Tremblay A,Provencher DM,Mes-Masson AM,Carmona E
MA5-11869 was used in western blot to study the expression of hyaluronidase-1 in different sub-types of epithelial ovarian cancer
Wed Nov 02 00:00:00 UTC 2011
Contribution of ARLTS1 Cys148Arg (T442C) variant with prostate cancer risk and ARLTS1 function in prostate cancer cells.
PloS one
Siltanen S,Wahlfors T,Schindler M,Saramäki OR,Mpindi JP,Latonen L,Vessella RL,Tammela TL,Kallioniemi O,Visakorpi T,Schleutker J
MA5-11869 was used in western blot to study the significance of the tumor supressor ARLTS-1 T442C mutation in the pathophysiology of prostate cancer
Fri Feb 24 00:00:00 UTC 2012
Oxidative damages in tubular epithelial cells in IgA nephropathy: role of crosstalk between angiotensin II and aldosterone.
Journal of translational medicine
Leung JC,Chan LY,Tang SC,Lam MF,Chow CW,Lim AI,Lai KN
MA5-11869 was used in western blot to study the roles of angiotensin II and aldosterone in the pathology of IgA nephropathy
Thu Oct 06 00:00:00 UTC 2011
Effects of EpCAM overexpression on human breast cancer cell lines.
BMC cancer
Gostner JM,Fong D,Wrulich OA,Lehne F,Zitt M,Hermann M,Krobitsch S,Martowicz A,Gastl G,Spizzo G
MA5-11869 was used in western blot to study the effects of EpCAM overexpression on the transcriptome, signaling, and proliferation of human breast cancer cell lines
Mon Jan 31 00:00:00 UTC 2011
Modulation of cellular Hsp72 levels in undifferentiated and neuron-like SH-SY5Y cells determines resistance to staurosporine-induced apoptosis.
PloS one
Cheng L,Smith DJ,Anderson RL,Nagley P
MA5-11869 was used in western blot to study the anti-apoptotic activity of HSP70 in both undifferentiated and neuron-like SH-SY5Y cells
Tue Feb 14 00:00:00 UTC 2012
A transmembrane protein EIG121L is required for epidermal differentiation during early embryonic development.
The Journal of biological chemistry
Araki T,Kusakabe M,Nishida E
MA5-11869 was used in western blot to study the role of the Xenopus transmembrane protein EIG121L in early embryonic epidermal differentiation
Fri Feb 25 00:00:00 UTC 2011
Disrupting 5-HT(2A) receptor/PDZ protein interactions reduces hyperalgesia and enhances SSRI efficacy in neuropathic pain.
Molecular therapy : the journal of the American Society of Gene Therapy
Pichon X,Wattiez AS,Becamel C,Ehrlich I,Bockaert J,Eschalier A,Marin P,Courteix C
MA5-11869 was used in western blot to study the effect of disrupting interactions bewteen the 5-HT(2A) receptor and PDZ on hyperalgesia and SSRI therapeutic action in diabetic neuropathic pain
Sun Aug 01 00:00:00 UTC 2010
Melatonin reprogrammes proteomic profile in light-exposed retina in vivo.
International journal of biological macromolecules
Zhang R,Hrushesky WJ,Wood PA,Lee SH,Hunt RC,Jahng WJ
MA5-11869 was used in western blot to study the in vivo effects of melatonin on the proteomics of light-exposed retina
Sun Aug 01 00:00:00 UTC 2010
Sulindac reverses aberrant expression and localization of beta-catenin in papillary thyroid cancer cells with the BRAFV600E mutation.
Thyroid : official journal of the American Thyroid Association
Cho NL,Lin CI,Whang EE,Carothers AM,Moore FD,Ruan DT
MA5-11869 was used in western blot to study the effect of nonsteroidal antiinflammatory drug sulindac on beta-catenin in papillary thyroid cancer cells
Tue Jun 01 00:00:00 UTC 2010
Autophagy induction with RAD001 enhances chemosensitivity and radiosensitivity through Met inhibition in papillary thyroid cancer.
Molecular cancer research : MCR
Lin CI,Whang EE,Donner DB,Du J,Lorch J,He F,Jiang X,Price BD,Moore FD,Ruan DT
MA5-11869 was used in western blot to evaluate the therapeutic efficacy of autophagy activator RAD001 in the treatment of papillary thyroid cancer
Wed Sep 01 00:00:00 UTC 2010
Plasminogen stimulates propagation of protease-resistant prion protein in vitro.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Mays CE,Ryou C
MA5-11869 was used in western blot to study the role of plasminogen in prion propagation
Wed Dec 01 00:00:00 UTC 2010
Serum cellular apoptosis susceptibility protein is a potential prognostic marker for metastatic colorectal cancer.
The American journal of pathology
Stella Tsai CS,Chen HC,Tung JN,Tsou SS,Tsao TY,Liao CF,Chen YC,Yeh CY,Yeh KT,Jiang MC
MA5-11869 was used in western blot to investigate the prognostic value of serum cellular apoptosis susceptibility protein CSE1L/CAS for metastatic colorectal cancer
Thu Apr 01 00:00:00 UTC 2010
Ouabain-induced apoptosis and Rho kinase: a novel caspase-2 cleavage site and fragment of Rock-2.
Apoptosis : an international journal on programmed cell death
Ark M,Ozdemir A,Polat B
MA5-11869 was used in western blot to study the role of Rho kinases in ouabain-induced human umbilical vein endothelial cell apoptosis
Wed Dec 01 00:00:00 UTC 2010
Mitochondrial Hep27 is a c-Myb target gene that inhibits Mdm2 and stabilizes p53.
Molecular and cellular biology
Deisenroth C,Thorner AR,Enomoto T,Perou CM,Zhang Y
MA5-11869 was used in western blot to study the role of mitochondrial Hep27 in inhibiting Mdm2 and stabilizing p53
Sun Aug 01 00:00:00 UTC 2010
Effect of chromium and cobalt ions on the expression of antioxidant enzymes in human U937 macrophage-like cells.
Journal of biomedical materials research. Part A
Tkaczyk C,Huk OL,Mwale F,Antoniou J,Zukor DJ,Petit A,Tabrizian M
MA5-11869 was used in western blot to study the differential effects of Co(2+), Cr(3+) and Cr(4+) ions on the expression of U937 macrophage antioxidant enzymes
Sun Aug 01 00:00:00 UTC 2010
Transactivation of ErbB-2 induced by tumor necrosis factor alpha promotes NF-kappaB activation and breast cancer cell proliferation.
Breast cancer research and treatment
Rivas MA,Tkach M,Beguelin W,Proietti CJ,Rosemblit C,Charreau EH,Elizalde PV,Schillaci R
MA5-11869 was used in western blot to study the role of ErbB2 transactivation in promoting NFkB activation and breast cancer cell proliferation
Thu Jul 01 00:00:00 UTC 2010
Fibroblast nemosis induces angiogenic responses of endothelial cells.
Experimental cell research
Enzerink A,Rantanen V,Vaheri A
MA5-11869 was used in western blot to study angiogenic responses of endothelial cells and the role of fibroblast nemosis
Wed Mar 10 00:00:00 UTC 2010
Increased cellular apoptosis susceptibility (CSE1L/CAS) protein expression promotes protrusion extension and enhances migration of MCF-7 breast cancer cells.
Experimental cell research
Tai CJ,Shen SC,Lee WR,Liao CF,Deng WP,Chiou HY,Hsieh CI,Tung JN,Chen CS,Chiou JF,Li LT,Lin CY,Hsu CH,Jiang MC
MA5-11869 was used in western blot to report that CSE1L regulates the association of alpha-tubulin with beta-tubulin and promotes migration of MCF-7 breast cancer cells
Fri Oct 15 00:00:00 UTC 2010
Maternal deprivation induces a rapid decline in circulating leptin levels and sexually dimorphic modifications in hypothalamic trophic factors and cell turnover.
Hormones and behavior
Viveros MP,Díaz F,Mateos B,Rodríguez N,Chowen JA
MA5-11869 was used in western blot to study gender differences in the effect of maternal deprivation on levels of leptin and hypothalamic trophic factors in rats
Thu Apr 01 00:00:00 UTC 2010
Activation of Na+/H+ exchanger 1 by neurotensin signaling in pancreatic cancer cell lines.
Biochemical and biophysical research communications
Olszewski U,Hlozek M,Hamilton G
MA5-11869 was used in western blot to investigate the mechanism for cellular pH regulation in response to neurotensin signaling
Fri Mar 12 00:00:00 UTC 2010
Phosphorylation of the cool-1/beta-Pix protein serves as a regulatory signal for the migration and invasive activity of Src-transformed cells.
The Journal of biological chemistry
Feng Q,Baird D,Yoo S,Antonyak M,Cerione RA
MA5-11869 was used in western blot to study the migration and invasiveness of Src-transformed cells and the modulatory role of Cool-1/beta-Pix Tyr442 phosphorylation
Fri Jun 11 00:00:00 UTC 2010
Separating lentiviral vector injection and induction of gene expression in time, does not prevent an immune response to rtTA in rats.
PloS one
Markusic DM,de Waart DR,Seppen J
MA5-11869 was used in western blot to study whether temporal separation of lentiviral vector injection and induction of target protein and rtTA expression reduces the immune response in muscle
Thu Apr 01 00:00:00 UTC 2010
Identification of tetranectin as a potential biomarker for metastatic oral cancer.
International journal of molecular sciences
Arellano-Garcia ME,Li R,Liu X,Xie Y,Yan X,Loo JA,Hu S
MA5-11869 was used in western blot to study the utility of serum or saliva tetranectin as a metastatic oral cancer biomarker
Thu Sep 02 00:00:00 UTC 2010
Responsiveness to PI3K and MEK inhibitors in breast cancer. Use of a 3D culture system to study pathways related to hormone independence in mice.
PloS one
Polo ML,Arnoni MV,Riggio M,Wargon V,Lanari C,Novaro V
MA5-11869 was used in western blot to characterize a mouse model of endocrine-resistant breast cancer
Wed May 26 00:00:00 UTC 2010
Identification of AML1-ETO modulators by chemical genomics.
Blood
Corsello SM,Roti G,Ross KN,Chow KT,Galinsky I,DeAngelo DJ,Stone RM,Kung AL,Golub TR,Stegmaier K
MA5-11869 was used in western blot to perform a chemical genomic screen to identify modulators of AML1-ETO with therapeutic potential
Thu Jun 11 00:00:00 UTC 2009
Epidermal growth factor receptor/beta-catenin/T-cell factor 4/matrix metalloproteinase 1: a new pathway for regulating keratinocyte invasiveness after UVA irradiation.
Cancer research
Jean C,Blanc A,Prade-Houdellier N,Ysebaert L,Hernandez-Pigeon H,Al Saati T,Haure MJ,Coluccia AM,Charveron M,Delabesse E,Laurent G
MA5-11869 was used in western blot to study the role of a novel EGFR/beta-catenin/T-cell factor 4/MMP-1 pathway in regulating keratinocyte invasiveness following UVA irradiation
Wed Apr 15 00:00:00 UTC 2009
Increased expression of androgen receptor sensitizes prostate cancer cells to low levels of androgens.
Cancer research
Waltering KK,Helenius MA,Sahu B,Manni V,Linja MJ,Jänne OA,Visakorpi T
MA5-11869 was used in western blot to study the role of increased expression of androgen receptor in sensitizing prostate cancer cells to low levels of androgens
Thu Oct 15 00:00:00 UTC 2009
Activation of the abundant nuclear factor poly(ADP-ribose) polymerase-1 by Helicobacter pylori.
Proceedings of the National Academy of Sciences of the United States of America
Nossa CW,Jain P,Tamilselvam B,Gupta VR,Chen LF,Schreiber V,Desnoyers S,Blanke SR
MA5-11869 was used in western blot to identify the mechanism of bacterial interference in host cell signaling
Tue Nov 24 00:00:00 UTC 2009
IGFBP2 is a candidate biomarker for Ink4a-Arf status and a therapeutic target for high-grade gliomas.
Proceedings of the National Academy of Sciences of the United States of America
Moore LM,Holmes KM,Smith SM,Wu Y,Tchougounova E,Uhrbom L,Sawaya R,Bruner JM,Fuller GN,Zhang W
MA5-11869 was used in western blot to investigate the diagnostic and therapeutic value of IGFBP 2 in glioma
Tue Sep 29 00:00:00 UTC 2009
Non-viral Smad7 gene delivery and attenuation of postoperative peritoneal adhesion in an experimental model.
The British journal of surgery
Guo H,Leung JC,Cheung JS,Chan LY,Wu EX,Lai KN
MA5-11869 was used in western blot to study the potential of exogenous Smad7 to prevent fibrogenesis in postoperative peritoneal adhesion
Sun Nov 01 00:00:00 UTC 2009
Roles of neutrophil gelatinase-associated lipocalin in continuous ambulatory peritoneal dialysis-related peritonitis.
Journal of clinical immunology
Leung JC,Lam MF,Tang SC,Chan LY,Tam KY,Yip TP,Lai KN
MA5-11869 was used in western blot to study the role of neutrophil gelatinase-associated lipocalin in peritonitis in peritoneal dialysis patients
Fri May 01 00:00:00 UTC 2009
Anti-inflammatory effects of caffeic acid phenethyl ester (CAPE), a nuclear factor-kappaB inhibitor, on Helicobacter pylori-induced gastritis in Mongolian gerbils.
International journal of cancer
Toyoda T,Tsukamoto T,Takasu S,Shi L,Hirano N,Ban H,Kumagai T,Tatematsu M
MA5-11869 was used in western blot to investigate the influence of nuclear factor-kappaB inhibitor caffeic acid phenethyl ester on the gastritis induced by Helicobacter pylori in Mongolian gerbils
Thu Oct 15 00:00:00 UTC 2009
Diminished intracellular invariant chain expression after vaccinia virus infection.
Journal of immunology (Baltimore, Md. : 1950)
Wang N,Weber E,Blum JS
MA5-11869 was used in western blot to study the mechanism by which vaccinia virus infection decreases intracellular invariant chain expression
Sat Aug 01 00:00:00 UTC 2009
Monitoring of the immunomodulatory effect of CP-690,550 by analysis of the JAK/STAT pathway in kidney transplant patients.
Transplantation
Quaedackers ME,Mol W,Korevaar SS,van Gurp EA,van Ijcken WF,Chan G,Weimar W,Baan CC
MA5-11869 was used in western blot to study the immunomodulatory effects of a small molecule Janus kinase-3 inhibitor in kidney transplant patients by ex vivo measurement of STAT5 phosphoylation status
Tue Oct 27 00:00:00 UTC 2009
Intracellular adaptation of Brucella abortus.
Journal of proteome research
Lamontagne J,Forest A,Marazzo E,Denis F,Butler H,Michaud JF,Boucher L,Pedro I,Villeneuve A,Sitnikov D,Trudel K,Nassif N,Boudjelti D,Tomaki F,Chaves-Olarte E,Guzmán-Verri C,Brunet S,Côté-Martin A,Hunter J,Moreno E,Paramithiotis E
MA5-11869 was used in western blot to study the mechanisms by which Brucella establishes intracellular infections
Sun Mar 01 00:00:00 UTC 2009
EHD3 regulates early-endosome-to-Golgi transport and preserves Golgi morphology.
Journal of cell science
Naslavsky N,McKenzie J,Altan-Bonnet N,Sheff D,Caplan S
MA5-11869 was used in western blot to study the role of EHD3 in the regulation of endosome-to-Golgi transport
Sun Feb 01 00:00:00 UTC 2009
The transcription-independent mitochondrial p53 program is a major contributor to nutlin-induced apoptosis in tumor cells.
Cell cycle (Georgetown, Tex.)
Vaseva AV,Marchenko ND,Moll UM
MA5-11869 was used in western blot to study the role of the transcription-independent mitochondrial p53 program in nutlin-induced apoptosis in tumor cells
Mon Jun 01 00:00:00 UTC 2009
SDF-1 alpha expression during wound healing in the aged is HIF dependent.
Plastic and reconstructive surgery
Loh SA,Chang EI,Galvez MG,Thangarajah H,El-Ftesi S,Vial IN,Lin DA,Gurtner GC
MA5-11869 was used in western blot to study the role of IL-1 beta and HIF-1 alpha in SDF-1 alpha expression during wound healing in aged mice
Sun Feb 01 00:00:00 UTC 2009
Activation of Stat3 by heregulin/ErbB-2 through the co-option of progesterone receptor signaling drives breast cancer growth.
Molecular and cellular biology
Proietti CJ,Rosemblit C,Beguelin W,Rivas MA,Díaz Flaqué MC,Charreau EH,Schillaci R,Elizalde PV
MA5-11869 was used in western blot to investigate the role of Stat3 in the tumorigenic effect of heregulin/ErbB-2 in breast cells
Sun Mar 01 00:00:00 UTC 2009
Progesterone receptor membrane component-1 regulates the development and Cisplatin sensitivity of human ovarian tumors in athymic nude mice.
Endocrinology
Peluso JJ,Gawkowska A,Liu X,Shioda T,Pru JK
MA5-11869 was used in western blot to study the role of PGRMC1 in the development of cisplatin resistance by human ovarian tumors
Sun Nov 01 00:00:00 UTC 2009
Proteomic approach to ETV5 during endometrial carcinoma invasion reveals a link to oxidative stress.
Carcinogenesis
Monge M,Colas E,Doll A,Gil-Moreno A,Castellvi J,Diaz B,Gonzalez M,Lopez-Lopez R,Xercavins J,Carreras R,Alameda F,Canals F,Gabrielli F,Reventos J,Abal M
MA5-11869 was used in western blot to study the proteomics of the ETV5 transcription factor during endometrial carcinoma invasion
Sat Aug 01 00:00:00 UTC 2009
Embryonic stem cells lacking the epigenetic regulator Cfp1 are hypersensitive to DNA-damaging agents and exhibit decreased Ape1/Ref-1 protein expression and endonuclease activity.
DNA repair
Tate CM,Fishel ML,Holleran JL,Egorin MJ,Skalnik DG
MA5-11869 was used in western blot to study the hypersensitivity to DNA-damaging agents of embryonic stem cells lacking the epigenetic regulator Cfp1
Thu Dec 03 00:00:00 UTC 2009
Diurnal expression of the rat intestinal sodium-glucose cotransporter 1 (SGLT1) is independent of local luminal factors.
Surgery
Stearns AT,Balakrishnan A,Rhoads DB,Ashley SW,Tavakkolizadeh A
MA5-11869 was used in western blot to study whether local nutritional signals influence the diurnal regulation of SGLT1 expression in the rat intestine
Sun Mar 01 00:00:00 UTC 2009
Autophagy: a new target for advanced papillary thyroid cancer therapy.
Surgery
Lin CI,Whang EE,Abramson MA,Jiang X,Price BD,Donner DB,Moore FD,Ruan DT
MA5-11869 was used in western blot to investigate the therapeutic benefit of autophagy inhibition in the tretment of advanced papillary thyroid cancer
Tue Dec 01 00:00:00 UTC 2009
Clustering of fibroblasts induces proinflammatory chemokine secretion promoting leukocyte migration.
Molecular immunology
Enzerink A,Salmenperä P,Kankuri E,Vaheri A
MA5-11869 was used in western blot to study the role of fibroblast clustering in inducing proinflammatory chemokine secretion and leukocyte migration
Fri May 01 00:00:00 UTC 2009
Short and long-term tumor cell responses to Aurora kinase inhibitors.
Experimental cell research
Dreier MR,Grabovich AZ,Katusin JD,Taylor WR
MA5-11869 was used in western blot to study tumor cell responses to Aurora kinase inhibitors
Wed Apr 15 00:00:00 UTC 2009
Higher prevalence of secretory CSE1L/CAS in sera of patients with metastatic cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Tung MC,Tsai CS,Tung JN,Tsao TY,Chen HC,Yeh KT,Liao CF,Jiang MC
MA5-11869 was used in western blot to evaluate the secretory CSE1L/CAS as a diagnostic marker in cancer metastasis
Fri May 01 00:00:00 UTC 2009
p53-dependent antiproliferative and antitumor effect of novel alkyl series of diorganotin(IV) compounds.
Investigational new drugs
Koch B,Basu Baul TS,Chatterjee A
MA5-11869 was used in western blot to investigate the effect of diorganotin dichloride complexes on tumor growth
Sat Aug 01 00:00:00 UTC 2009
Structural factors and mechanisms underlying the improved photodynamic cell killing with silicon phthalocyanine photosensitizers directed to lysosomes versus mitochondria.
Photochemistry and photobiology
Rodriguez ME,Zhang P,Azizuddin K,Delos Santos GB,Chiu SM,Xue LY,Berlin JC,Peng X,Wu H,Lam M,Nieminen AL,Kenney ME,Oleinick NL
MA5-11869 was used in western blot to study the mechanisms underlying the increased photodynamic killing activity of silicon phthalocyanin photosensitizers that preferentially localize to lysosomes
Thu Dec 03 00:00:00 UTC 2009
Galectin-3 regulates apoptosis and doxorubicin chemoresistance in papillary thyroid cancer cells.
Biochemical and biophysical research communications
Lin CI,Whang EE,Abramson MA,Donner DB,Bertagnolli MM,Moore FD,Ruan DT
MA5-11869 was used in western blot to investigate the influence of galectin-3 on cell survival and drug resistance in PTC cells
Fri Feb 06 00:00:00 UTC 2009
Puerariae radix isoflavones and their metabolites inhibit growth and induce apoptosis in breast cancer cells.
Biochemical and biophysical research communications
Lin YJ,Hou YC,Lin CH,Hsu YA,Sheu JJ,Lai CH,Chen BH,Lee Chao PD,Wan L,Tsai FJ
MA5-11869 was used in western blot to study the effect of Puerariae radix isoflavones on growth and apoptosis in breast cancer cells
Fri Jan 23 00:00:00 UTC 2009
Expression of apoptotic tumour necrosis factor receptor-associated factor, caspase recruitment domain and cell death-inducing DFF-45 effector genes in therapy-treated renal cell carcinoma.
Nephrology (Carlton, Vic.)
Rajandram R,Pat BK,Li J,Johnson DW,Gobe GC
MA5-11869 was used in western blot to study the expression of apoptosis-related genes not previously characterized with respect to renal cell carcinoma
Wed Apr 01 00:00:00 UTC 2009
Classic and desmoplastic medulloblastoma: complete case reports and characterizations of two new cell lines.
Neuropathology : official journal of the Japanese Society of Neuropathology
Holthouse DJ,Dallas PB,Ford J,Fabian V,Murch AR,Watson M,Wong G,Bertram C,Egli S,Baker DL,Kees UR
MA5-11869 was used in western blot to report on two cases of classic and desmoplastic medulloblastoma and the characterization of two new cell lines
Sat Aug 01 00:00:00 UTC 2009
Tissue transglutaminase is an essential participant in the epidermal growth factor-stimulated signaling pathway leading to cancer cell migration and invasion.
The Journal of biological chemistry
Antonyak MA,Li B,Regan AD,Feng Q,Dusaban SS,Cerione RA
MA5-11869 was used in western blot to study the essential role of tissue transglutaminase in EGF-stimulated cell migration and invasion in a HeLa cancer cell model
Fri Jul 03 00:00:00 UTC 2009
The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is required for normal mitosis in mammalian cells.
The Journal of biological chemistry
Cummings CM,Bentley CA,Perdue SA,Baas PW,Singer JD
MA5-11869 was used in western blot to study the interaction of the Cul3/Klhdc5 E3 ubiquitin ligase with p60/katenin and its regulatory role in normal mammalian cell mitosis
Fri Apr 24 00:00:00 UTC 2009
Increased renal gene transcription of protein kinase C-beta in human diabetic nephropathy: relationship to long-term glycaemic control.
Diabetologia
Langham RG,Kelly DJ,Gow RM,Zhang Y,Cox AJ,Qi W,Thai K,Pollock CA,Christensen PK,Parving HH,Gilbert RE
MA5-11869 was used in western blot to study whether diabetic nephropathy leads to increased transcription of PKC-alpha and PKC-beta
Tue Apr 01 00:00:00 UTC 2008
Nemosis of fibroblasts is inhibited by benign HaCaT keratinocytes but promoted by malignant HaCaT cells.
Molecular oncology
Räsänen K,Salmenperä P,Baumann M,Virtanen I,Vaheri A
MA5-11869 was used in western blot to investigate the opposing effect between benign and malignant HaCaT cells on nemosis of fibroblasts
Mon Dec 01 00:00:00 UTC 2008
Dulxanthone A induces cell cycle arrest and apoptosis via up-regulation of p53 through mitochondrial pathway in HepG2 cells.
International journal of cancer
Tian Z,Shen J,Moseman AP,Yang Q,Yang J,Xiao P,Wu E,Kohane IS
MA5-11869 was used in western blot to study the mechanism by which dulxanthone A induces cell cycle arrest and apoptosis in HepG2 cells
Tue Jan 01 00:00:00 UTC 2008
Anti-adult T-cell leukemia effects of brown algae fucoxanthin and its deacetylated product, fucoxanthinol.
International journal of cancer
Ishikawa C,Tafuku S,Kadekaru T,Sawada S,Tomita M,Okudaira T,Nakazato T,Toda T,Uchihara JN,Taira N,Ohshiro K,Yasumoto T,Ohta T,Mori N
MA5-11869 was used in western blot to study the effects and mechanisms of action of fucoxanthin and fucoxanthinol against adult T-cell leukemia cells
Mon Dec 01 00:00:00 UTC 2008
Characterization of epithelial IL-8 response to inflammatory bowel disease mucosal E. coli and its inhibition by mesalamine.
Inflammatory bowel diseases
Subramanian S,Rhodes JM,Hart CA,Tam B,Roberts CL,Smith SL,Corkill JE,Winstanley C,Virji M,Campbell BJ
MA5-11869 was used in western blot to study the mechanisms by which adherent E.coli promote IL-8 release in inflammatory bowel disease and the inhibitory effects of mesalamine
Fri Feb 01 00:00:00 UTC 2008
Synthesis of TNF-alpha by mesangial cells cultured with polymeric anionic IgA--role of MAPK and NF-kappaB.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
Leung JC,Tang SC,Chan LY,Chan WL,Lai KN
MA5-11869 was used in western blot to study the role of MAPK and NFkB in the synthesis of TNFalpha by mesangial cells cultured with polymeric anionic IgA
Tue Jan 01 00:00:00 UTC 2008
(-)-Anonaine induces apoptosis through Bax- and caspase-dependent pathways in human cervical cancer (HeLa) cells.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Chen CY,Liu TZ,Tseng WC,Lu FJ,Hung RP,Chen CH,Chen CH
MA5-11869 was used in western blot to study the roles of Bax and caspases in the mechanism by which (-)-anonaine induces apoptosis in HeLa cells
Fri Aug 01 00:00:00 UTC 2008
Phosphorylated Ssk1 prevents unphosphorylated Ssk1 from activating the Ssk2 mitogen-activated protein kinase kinase kinase in the yeast high-osmolarity glycerol osmoregulatory pathway.
Molecular and cellular biology
Horie T,Tatebayashi K,Yamada R,Saito H
MA5-11869 was used in western blot to study the role of Ssk1 phosphorylation status in regulating the activation of the Ssk2 MAPK kinase kinase involved in yeast osmoregulation
Mon Sep 01 00:00:00 UTC 2008
Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally.
Molecular and cellular biology
Zhang Y,Kwon S,Yamaguchi T,Cubizolles F,Rousseaux S,Kneissel M,Cao C,Li N,Cheng HL,Chua K,Lombard D,Mizeracki A,Matthias G,Alt FW,Khochbin S,Matthias P
MA5-11869 was used in western blot to study the characteristics of knockout mice lacking HDAC6
Sat Mar 01 00:00:00 UTC 2008
Mitogen-stimulated and rapamycin-sensitive glucose transporter 12 targeting and functional glucose transport in renal epithelial cells.
Endocrinology
Wilson-O'Brien AL,Dehaan CL,Rogers S
MA5-11869 was used in western blot to study the effects of mitogens and rapamycin on GLUT12 trafficking and glucose transport in renal epithelial cells
Sat Mar 01 00:00:00 UTC 2008
Mammalian hyaluronidase induces ovarian granulosa cell apoptosis and is involved in follicular atresia.
Endocrinology
Orimoto AM,Dumaresq-Doiron K,Jiang JY,Tanphaichitr N,Tsang BK,Carmona E
MA5-11869 was used in western blot to study the possible involvement of mammalian hyaluronidases in ovarian atresia
Sat Nov 01 00:00:00 UTC 2008
Hepatocyte growth factor improves viability after H2O2-induced toxicity in bile duct epithelial cells.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP
Arends B,Slump E,Spee B,Rothuizen J,Penning LC
MA5-11869 was used in western blot to study the effect of HGF on the viability of bile duct epithelial cells following H2O2-induced toxicity
Tue Apr 01 00:00:00 UTC 2008
Expression of epithelial cadherin in the human male reproductive tract and gametes and evidence of its participation in fertilization.
Molecular human reproduction
Marín-Briggiler CI,Veiga MF,Matos ML,Echeverría MF,Furlong LI,Vazquez-Levin MH
MA5-11869 was used in western blot to ascertain the role of epithelial cadherin in gamete interaction
Wed Oct 01 00:00:00 UTC 2008
NBS1 regulates a novel apoptotic pathway through Bax activation.
DNA repair
Iijima K,Muranaka C,Kobayashi J,Sakamoto S,Komatsu K,Matsuura S,Kubota N,Tauchi H
MA5-11869 was used in western blot to study the regulation of a novel p53-independent apoptotic pathway
Wed Oct 01 00:00:00 UTC 2008
Knockdown of the DNA repair and redox signaling protein Ape1/Ref-1 blocks ovarian cancer cell and tumor growth.
DNA repair
Fishel ML,He Y,Reed AM,Chin-Sinex H,Hutchins GD,Mendonca MS,Kelley MR
MA5-11869 was used in western blot to study the role of the DNA repair and redox signaling protein Ape1/Ref-1 in ovarian cancer cell and tumor growth
Fri Feb 01 00:00:00 UTC 2008
Diurnal rhythmicity in glucose uptake is mediated by temporal periodicity in the expression of the sodium-glucose cotransporter (SGLT1).
Surgery
Balakrishnan A,Stearns AT,Rounds J,Irani J,Giuffrida M,Rhoads DB,Ashley SW,Tavakkolizadeh A
MA5-11869 was used in western blot to study temporal changes in glucose transport mediated by the Na(+)/glucose cotransporter SGLT1
Sun Jun 01 00:00:00 UTC 2008
Estrogen induces rapid translocation of estrogen receptor beta, but not estrogen receptor alpha, to the neuronal plasma membrane.
Neuroscience
Sheldahl LC,Shapiro RA,Bryant DN,Koerner IP,Dorsa DM
MA5-11869 was used in western blot to investigate the effect of estrogen on cellular distribution of estrogen receptors alpha and beta
Thu May 15 00:00:00 UTC 2008
Cell proliferation inhibition and antitumor activity of novel alkyl series of diorganotin(IV) compounds.
Journal of applied toxicology : JAT
Koch B,Baul TS,Chatterjee A
MA5-11869 was used in western blot to investigate the effect of diorganotin compounds on cell proliferation and tumor growth
Thu May 01 00:00:00 UTC 2008
CRBL cells: establishment, characterization and susceptibility to prion infection.
Brain research
Mays CE,Kang HE,Kim Y,Shim SH,Bang JE,Woo HJ,Cho YH,Kim JB,Ryou C
MA5-11869 was used in western blot to characterize a new immortal cell lines for the study of prion pathogenesis
Wed May 07 00:00:00 UTC 2008
Effect of hemodialysis on hepatic cytochrome P450 functional expression.
Journal of pharmacological sciences
Michaud J,Nolin TD,Naud J,Dani M,Lafrance JP,Leblond FA,Himmelfarb J,Pichette V
MA5-11869 was used in western blot to study the functional expression of CYP1A, 2C, and 3A during conventional hemodialysis
Wed Oct 01 00:00:00 UTC 2008
Oocyte selection is concurrent with meiosis resumption in the coenocystic oogenesis of Oikopleura.
Developmental biology
Ganot P,Moosmann-Schulmeister A,Thompson EM
MA5-11869 was used in immunohistochemistry and western blot to study the growth and maturation of oocytes in the tunicate Oikopleura
Mon Dec 15 00:00:00 UTC 2008
Oocyte selection is concurrent with meiosis resumption in the coenocystic oogenesis of Oikopleura.
Developmental biology
Ganot P,Moosmann-Schulmeister A,Thompson EM
MA5-11869 was used in immunohistochemistry and western blot to study the growth and maturation of oocytes in the tunicate Oikopleura
Mon Dec 15 00:00:00 UTC 2008
Lithium treatment decreases activities of tau kinases in a murine model of senescence.
Journal of neuropathology and experimental neurology
Tajes M,Gutierrez-Cuesta J,Folch J,Ferrer I,Caballero B,Smith MA,Casadesus G,Camins A,Pallás M
MA5-11869 was used in western blot to study the effect of lithium on the acctivity of tau kinases in a mouse model of senescence
Sun Jun 01 00:00:00 UTC 2008
Exercise training with dietary counselling increases mitochondrial chaperone expression in middle-aged subjects with impaired glucose tolerance.
BMC endocrine disorders
Venojärvi M,Aunola S,Puhke R,Marniemi J,Hämäläinen H,Halonen JP,Lindström J,Rastas M,Hällsten K,Nuutila P,Hänninen O,Atalay M
MA5-11869 was used in western blot to study the effects of exercise and diet on mitochondrial chaperone expression in obese middle-aged subjects suffereing impaired glucose tolerance
Thu Mar 27 00:00:00 UTC 2008
Differential transferrin expression in placentae from normal and abnormal pregnancies: a pilot study.
Reproductive biology and endocrinology : RB&E
Kralova A,Svetlikova M,Madar J,Ulcova-Gallova Z,Bukovsky A,Peknicova J
MA5-11869 was used in western blot to compare placental transferrin expression following normal or abnormal pregnancies
Wed Jul 02 00:00:00 UTC 2008
In vivo analysis of protein kinase B (PKB)/Akt regulation in DNA-PKcs-null mice reveals a role for PKB/Akt in DNA damage response and tumorigenesis.
The Journal of biological chemistry
Surucu B,Bozulic L,Hynx D,Parcellier A,Hemmings BA
MA5-11869 was used in western blot to study the role of PKB/Akt in the DNA damage response and tumorigenesis using DNA-PKcs knockout mice
Fri Oct 31 00:00:00 UTC 2008
Gamma-secretase activation of notch signaling regulates the balance of proximal and distal fates in progenitor cells of the developing lung.
The Journal of biological chemistry
Tsao PN,Chen F,Izvolsky KI,Walker J,Kukuruzinska MA,Lu J,Cardoso WV
MA5-11869 was used in western blot to study the role of gamma-secretase activation of Notch signaling in regulating the fates of progenitor cells in the developing lung
Fri Oct 24 00:00:00 UTC 2008
Positive regulation of DNA double strand break repair activity during differentiation of long life span cells: the example of adipogenesis.
PloS one
Meulle A,Salles B,Daviaud D,Valet P,Muller C
MA5-11869 was used in western blot to study the reugulation of DNA double strand break repair activity during adipocyte differentiation
Wed Nov 12 00:00:00 UTC 2008
Identification of a hepatitis B virus S gene mutant in lamivudine-treated patients experiencing HBsAg seroclearance.
Gastroenterology
Hsu CW,Yeh CT,Chang ML,Liaw YF
MA5-11869 was used in western blot to study the mechanism and significance of HBsAg seroclearance in HBV patients treated with lamivudine
Thu Feb 01 00:00:00 UTC 2007
Angiogenesis is associated with blood-brain barrier permeability in temporal lobe epilepsy.
Brain : a journal of neurology
Rigau V,Morin M,Rousset MC,de Bock F,Lebrun A,Coubes P,Picot MC,Baldy-Moulinier M,Bockaert J,Crespel A,Lerner-Natoli M
MA5-11869 was used in western blot to compare hippocampi from temporal lobe epilepsy patients with those from non-epileptic patients
Sun Jul 01 00:00:00 UTC 2007
Smad7 transgene attenuates peritoneal fibrosis in uremic rats treated with peritoneal dialysis.
Journal of the American Society of Nephrology : JASN
Guo H,Leung JC,Lam MF,Chan LY,Tsang AW,Lan HY,Lai KN
MA5-11869 was used in western blot to study the role of the Smad7 transgene in reducing peritoneal fibrosis in uremic rats undergoing peritoneal dialysis
Mon Oct 01 00:00:00 UTC 2007
Loss of hepatocyte growth factor/c-Met signaling pathway accelerates early stages of N-nitrosodiethylamine induced hepatocarcinogenesis.
Cancer research
Takami T,Kaposi-Novak P,Uchida K,Gomez-Quiroz LE,Conner EA,Factor VM,Thorgeirsson SS
MA5-11869 was used in western blot to investigate the effect of c-Met signaling deficiency in hepatocytes on chemical hepatocarcinogenesis
Mon Oct 15 00:00:00 UTC 2007
Signature-based small molecule screening identifies cytosine arabinoside as an EWS/FLI modulator in Ewing sarcoma.
PLoS medicine
Stegmaier K,Wong JS,Ross KN,Chow KT,Peck D,Wright RD,Lessnick SL,Kung AL,Golub TR
MA5-11869 was used in western blot to develop a novel method for screening for small molecule modulators of EWS/FLI oncoprotein function in Ewing sarcoma
Sun Apr 01 00:00:00 UTC 2007
Association of estrogen receptor-alpha and progesterone receptor A expression with hormonal mammary carcinogenesis: role of the host microenvironment.
Breast cancer research : BCR
Montero Girard G,Vanzulli SI,Cerliani JP,Bottino MC,Bolado J,Vela J,Becu-Villalobos D,Benavides F,Gutkind S,Patel V,Molinolo A,Lanari C
MA5-11869 was used in western blot to study the role of the microenvironment on the differential association of ERalpha and progesterone receptor A with hormone mammary carcinogenesis in different mouse strains
Wed Jun 13 00:00:00 UTC 2007
Carvedilol, a pharmacological antioxidant, inhibits neointimal matrix metalloproteinase-2 and -9 in experimental atherosclerosis.
Free radical biology & medicine
Wu TC,Chen YH,Leu HB,Chen YL,Lin FY,Lin SJ,Chen JW
MA5-11869 was used in western blot to study the effects of carvedilol on MMP-2 and MMP-9 expression in experimental atherosclerosis
Sat Dec 01 00:00:00 UTC 2007
Sodium butyrate-induced death-associated protein kinase expression promote Raji cell morphological change and apoptosis by reducing FAK protein levels.
Acta pharmacologica Sinica
Zhang HT,Feng ZL,Wu J,Wang YJ,Guo X,Liang NC,Zhu ZY,Ma JQ
MA5-11869 was used in western blot to investigate the mechanism for the effect of death-associated protein kinase on Raji cell morphology and survival
Thu Nov 01 00:00:00 UTC 2007
Epithelial to mesenchymal transition predicts gefitinib resistance in cell lines of head and neck squamous cell carcinoma and non-small cell lung carcinoma.
Molecular cancer therapeutics
Frederick BA,Helfrich BA,Coldren CD,Zheng D,Chan D,Bunn PA,Raben D
MA5-11869 was used in western blot to investigate the mechanism for the gefitinib resistance in head and neck squamous cell carcinoma and non-small cell lung carcinoma
Fri Jun 01 00:00:00 UTC 2007
Cimicifuga foetida extract inhibits proliferation of hepatocellular cells via induction of cell cycle arrest and apoptosis.
Journal of ethnopharmacology
Tian Z,Pan R,Chang Q,Si J,Xiao P,Wu E
MA5-11869 was used in western blot to study the mechanism by which an extract of Cimicifuga foetida inhibits proliferation of hepatocellular cells
Thu Nov 01 00:00:00 UTC 2007
Exogenous IL-10 overexpression reduces perforin production by activated allogenic CD8+ cells and prolongs cardiac allograft survival.
American journal of physiology. Heart and circulatory physiology
Oshima K,Cui G,Tung T,Okotie O,Laks H,Sen L
MA5-11869 was used in western blot to study the role of perforin in the mechanism by which overexpression of exogenous IL-10 enhances cardiac allograft survival
Mon Jan 01 00:00:00 UTC 2007
Prolactin stimulates prostate cell proliferation by increasing endoplasmic reticulum content due to SERCA 2b over-expression.
The Biochemical journal
Crépin A,Bidaux G,Vanden-Abeele F,Dewailly E,Goffin V,Prevarskaya N,Slomianny C
MA5-11869 was used in western blot to study the role of SERCA2b overexpression and endoplasmic calcium metabolism in the stimulation of prostate cell growth by prolactin
Mon Jan 01 00:00:00 UTC 2007
Coincident regulation of PKCdelta in human platelets by phosphorylation of Tyr311 and Tyr565 and phospholipase C signalling.
The Biochemical journal
Hall KJ,Jones ML,Poole AW
MA5-11869 was used in western blot to study the co-regulation of PKCdelta in human platelets by phosphorylation of Tyr311 and Tyr565 and phospholipase C signalling
Sat Sep 15 00:00:00 UTC 2007
Reg-II is an exocrine pancreas injury-response product that is up-regulated by keratin absence or mutation.
Molecular biology of the cell
Zhong B,Strnad P,Toivola DM,Tao GZ,Ji X,Greenberg HB,Omary MB
MA5-11869 was used in western blot to study the role of Reg II as a cytoprotective protein in the exocrine pancreas and its regulation by keratin filaments
Sat Dec 01 00:00:00 UTC 2007
Heavy ion beams induce survivin expression in human hepatoma SMMC-7721 cells more effectively than X-rays.
Acta biochimica et biophysica Sinica
Gong L,Jin X,Li Q,Liu J,An L
MA5-11869 was used in western blot to compare the ability of heavy ion beams and X-rays to induce survivin expression in human hepatoma cells
Wed Aug 01 00:00:00 UTC 2007
Influence of glutathione on the induction of chromosome aberrations, delay in cell cycle kinetics and cell cycle regulator proteins in irradiated mouse bone marrow cells.
International journal of radiation biology
Ray S,Chatterjee A
MA5-11869 was used in western blot to investigate the effect of glutathione on chromosome aberrations, cell cycle kinetics, and cell cycle regulator proteins
Tue May 01 00:00:00 UTC 2007
Inhibition of NAD(P)H oxidase reduces fibronectin expression in stroke-prone renovascular hypertensive rat brain.
Clinical and experimental pharmacology & physiology
Cui C,Chen AF,Jiang Z,Wu Q,Lin J,Wen H,Zeng J
MA5-11869 was used in western blot to study the role of NAD(H) oxidase inhibition in reducing fibronectin expression in a hypertensive stroke model
Sun Apr 01 00:00:00 UTC 2007
Effect of huanglian jiedu decoction ) on glucose transporter 4 expression in adipose and skeletal muscle tissues of insulin resistant rats.
Chinese journal of integrative medicine
Chen G,Lu FE,Jin D,Xu LJ,Wang KF
MA5-11869 was used in western blot to study the effect of huanglian jiedu decoction on glucose transporter 4 expression in adipose and skeletal muscle tissues of insulin resistant rats
Thu Mar 01 00:00:00 UTC 2007
P53-Rb signaling pathway is involved in tubular cell senescence in renal ischemia/reperfusion injury.
Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al
Kailong L,Du X,Yani H,Lin Z,Jvrong Y,Ruihua S,Lin C
MA5-11869 was used in western blot to investigate the involvement of p53-Rb signaling pathway in tubular cell senescence in the kidney during the late phase of ischemia/reperfusion
Wed Aug 01 00:00:00 UTC 2007
Influence of warm ischemia time on peripheral-type benzodiazepine receptor: a new aspect of the role of mitochondria.
Nephron. Experimental nephrology
Doucet C,Zhang K,Desurmont T,Hebrard W,Scepi M,Nadeau C,Cau J,Leyre P,Febrer G,Carretier M,Richer JP,Papadopoulos V,Hauet T,Burucoa C,Goujon JM
MA5-11869 was used in western blot to study the effects of warm ischemia on renal function and peripheral benzodiazepine receptor expression in a porcine model
Tue Oct 02 00:00:00 UTC 2007
UVA induces granzyme B in human keratinocytes through MIF: implication in extracellular matrix remodeling.
The Journal of biological chemistry
Hernandez-Pigeon H,Jean C,Charruyer A,Haure MJ,Baudouin C,Charveron M,Quillet-Mary A,Laurent G
MA5-11869 was used in western blot to study the role of MIF in UVA induced-granzyme B expression in human keratinocytes
Fri Mar 16 00:00:00 UTC 2007
Progestin effects on breast cancer cell proliferation, proteases activation, and in vivo development of metastatic phenotype all depend on progesterone receptor capacity to activate cytoplasmic signaling pathways.
Molecular endocrinology (Baltimore, Md.)
Carnevale RP,Proietti CJ,Salatino M,Urtreger A,Peluffo G,Edwards DP,Boonyaratanakornkit V,Charreau EH,Bal de Kier Joffé E,Schillaci R,Elizalde PV
MA5-11869 was used in western blot to study the relationship between the ability of the progesterone receptor to activate cytoplasmic signaling and the ability of progestin to promote a metastatic breast cancer phenotype
Fri Jun 01 00:00:00 UTC 2007
The N-terminus and alpha-5, alpha-6 helices of the pro-apoptotic protein Bax, modulate functional interactions with the anti-apoptotic protein Bcl-xL.
BMC cell biology
Parikh N,Koshy C,Dhayabaran V,Perumalsamy LR,Sowdhamini R,Sarin A
MA5-11869 was used in western blot to investigate the relationship and interaction between Bax and Bcl-xL
Wed May 23 00:00:00 UTC 2007
Analysis of mitotic phosphorylation of borealin.
BMC cell biology
Kaur H,Stiff AC,Date DA,Taylor WR
MA5-11869 was used in western blot to study the phosphorylation of borealin during mitosis
Mon Jan 22 00:00:00 UTC 2007
Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families.
The Journal of biological chemistry
Kim M,Hersh LB,Leissring MA,Ingelsson M,Matsui T,Farris W,Lu A,Hyman BT,Selkoe DJ,Bertram L,Tanzi RE
MA5-11869 was used in western blot to study decreased catalytic activity of insulin-degrading enzyme in chromosome 10-linked Alzheimer disease
Fri Mar 16 00:00:00 UTC 2007
Efficient intervention of growth and infiltration of primary adult T-cell leukemia cells by an HIV protease inhibitor, ritonavir.
Blood
Dewan MZ,Uchihara JN,Terashima K,Honda M,Sata T,Ito M,Fujii N,Uozumi K,Tsukasaki K,Tomonaga M,Kubuki Y,Okayama A,Toi M,Mori N,Yamamoto N
MA5-11869 was used in western blot to study the effect of the HIV protease inhibitor ritonavir on the growth and infiltration of HTLV-I-infected T-cell lines and primary adult T-cell leukemia cells
Sun Jan 15 00:00:00 UTC 2006
Constitutive activation of Akt contributes to the pathogenesis and survival of mantle cell lymphoma.
Blood
Rudelius M,Pittaluga S,Nishizuka S,Pham TH,Fend F,Jaffe ES,Quintanilla-Martinez L,Raffeld M
MA5-11869 was used in western blot to study the role of the PI3 kinase/Akt pathway in mantle cell lymphoma pathogenesis
Fri Sep 01 00:00:00 UTC 2006
Leptin induces TGF-beta synthesis through functional leptin receptor expressed by human peritoneal mesothelial cell.
Kidney international
Leung JC,Chan LY,Tang SC,Chu KM,Lai KN
MA5-11869 was used in western blot to study whether human peritoneal mesothelial cells express functional leptin receptor and the possible significance for peritoneal dialysis
Thu Jun 01 00:00:00 UTC 2006
Improved surgical mesh integration into the rat abdominal wall with arginine administration.
Biomaterials
Arbos MA,Ferrando JM,Quiles MT,Vidal J,López-Cano M,Gil J,Manero JM,Peña J,Huguet P,Schwartz-Riera S,Reventós J,Armengol M
MA5-11869 was used in western blot to study the role of arginine administration in improving surgical mesh integration into the rat abdominal wall
Wed Feb 01 00:00:00 UTC 2006
Effect of cobalt and chromium ions on human MG-63 osteoblasts in vitro: morphology, cytotoxicity, and oxidative stress.
Biomaterials
Fleury C,Petit A,Mwale F,Antoniou J,Zukor DJ,Tabrizian M,Huk OL
MA5-11869 was used in western blot to study the effect of Co(2+) and Cr(3+) ions on human osteoblasts
Thu Jun 01 00:00:00 UTC 2006
Role of parathyroid hormone in the downregulation of liver cytochrome P450 in chronic renal failure.
Journal of the American Society of Nephrology : JASN
Michaud J,Naud J,Chouinard J,Désy F,Leblond FA,Desbiens K,Bonnardeaux A,Pichette V
MA5-11869 was used in western blot to study the role parathyroid hormone in the downregulation of liver cytochrome P450 in chronic renal failure
Wed Nov 01 00:00:00 UTC 2006
Lineage-specific activators affect beta-globin locus chromatin in multipotent hematopoietic progenitors.
The EMBO journal
Bottardi S,Ross J,Pierre-Charles N,Blank V,Milot E
MA5-11869 was used in western blot to study the effect of lineage-specific activators on beta-globin locus chromatin in multipotent hematopoietic progenitors
Wed Aug 09 00:00:00 UTC 2006
Mutations within the kinase domain and truncations of the epidermal growth factor receptor are rare events in bladder cancer: implications for therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research
Blehm KN,Spiess PE,Bondaruk JE,Dujka ME,Villares GJ,Zhao YJ,Bogler O,Aldape KD,Grossman HB,Adam L,McConkey DJ,Czerniak BA,Dinney CP,Bar-Eli M
MA5-11869 was used in western blot to study the therapeutic implications of mutations and truncations of the EGF receptor in bladder cancer
Tue Aug 01 00:00:00 UTC 2006
Altered glucose metabolism in childhood pre-B acute lymphoblastic leukaemia.
Leukemia
Boag JM,Beesley AH,Firth MJ,Freitas JR,Ford J,Hoffmann K,Cummings AJ,de Klerk NH,Kees UR
MA5-11869 was used in western blot to study glucose metabolism in childhood pre-B acute lymphoblastic leukaemia
Sun Oct 01 00:00:00 UTC 2006
Stress response in mesoangioblast stem cells.
Cell death and differentiation
Geraci F,Turturici G,Galli D,Cossu G,Giudice G,Sconzo G
MA5-11869 was used in western blot to study the ability of mesoangioblasts to respond to different cell stresses
Sat Jul 01 00:00:00 UTC 2006
ERK contributes to the effects of Smad signaling on oxidized LDL-induced PAI-1 expression in human mesangial cells.
Translational research : the journal of laboratory and clinical medicine
Hong HK,Song CY,Kim BC,Lee HS
MA5-11869 was used in western blot to study the role of Smad and ERK in the induction of PAI-1 expression by oxidised LDL in human mesangeal cells
Sun Oct 01 00:00:00 UTC 2006
Progestin-induced caveolin-1 expression mediates breast cancer cell proliferation.
Oncogene
Salatino M,Beguelin W,Peters MG,Carnevale R,Proietti CJ,Galigniana MD,Vedoy CG,Schillaci R,Charreau EH,Sogayar MC,Elizalde PV
MA5-11869 was used in western blot to investigate the role of caveolin-1 in breast cancer cell proliferation
Thu Dec 14 00:00:00 UTC 2006
The topoisomerase II-Hsp90 complex: a new chemotherapeutic target?
International journal of cancer
Barker CR,Hamlett J,Pennington SR,Burrows F,Lundgren K,Lough R,Watson AJ,Jenkins JR
MA5-11869 was used in immunoprecipitation and western blot to study the topoisomerase II-Hsp90 complex as a potential new chemotherapeutic target
Thu Jun 01 00:00:00 UTC 2006
Introduction of the MASH1 gene into mouse embryonic stem cells leads to differentiation of motoneuron precursors lacking Nogo receptor expression that can be applicable for transplantation to spinal cord injury.
Neurobiology of disease
Hamada M,Yoshikawa H,Ueda Y,Kurokawa MS,Watanabe K,Sakakibara M,Tadokoro M,Akashi K,Aoki H,Suzuki N
MA5-11869 was used in western blot to study the generation of motoneuron precursors laking the NOGO receptor by transfecting murine embryonic stem cells with MASH1
Thu Jun 01 00:00:00 UTC 2006
Proteomic analysis of Caco-2 cells treated with monacolin K.
Journal of agricultural and food chemistry
Lin WY,Song CY,Pan TM
MA5-11869 was used in western blot to perform a proteomic analysis of Caco-2 cells treated with monacolin K
Wed Aug 23 00:00:00 UTC 2006
Presenilin/gamma-secretase activity regulates protein clearance from the endocytic recycling compartment.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Zhang M,Haapasalo A,Kim DY,Ingano LA,Pettingell WH,Kovacs DM
MA5-11869 was used in western blot to study the role of presenilin/gamma-secretase in the clearance of proteins from the endocytic recycling compartment and the significance for neurodegeneration
Thu Jun 01 00:00:00 UTC 2006
Immunization with murine breast cancer cells treated with antisense oligodeoxynucleotides to type I insulin-like growth factor receptor induced an antitumoral effect mediated by a CD8+ response involving Fas/Fas ligand cytotoxic pathway.
Journal of immunology (Baltimore, Md. : 1950)
Schillaci R,Salatino M,Cassataro J,Proietti CJ,Giambartolomei GH,Rivas MA,Carnevale RP,Charreau EH,Elizalde PV
MA5-11869 was used in western blot to study the anti-tumor effects of anti-sense oligonucleotides to IGF-1R in murine breast cancer
Wed Mar 15 00:00:00 UTC 2006
Evidence for a role for notch signaling in the cytokine-dependent survival of activated T cells.
Journal of immunology (Baltimore, Md. : 1950)
Bheeshmachar G,Purushotaman D,Sade H,Gunasekharan V,Rangarajan A,Sarin A
MA5-11869 was used in western blot to study the potential role of Notch1 signaling in cytokine-dependent survival of activated T cells
Sun Oct 15 00:00:00 UTC 2006
Cobalt and chromium ions induce nitration of proteins in human U937 macrophages in vitro.
Journal of biomedical materials research. Part A
Petit A,Mwale F,Tkaczyk C,Antoniou J,Zukor DJ,Huk OL
MA5-11869 was used in western blot to study the ability of Co(2+) and Cr(3+) ions to induce protein tyrosine nitrosylation in human U937 macrophages
Fri Dec 01 00:00:00 UTC 2006
Inhibition of K+ efflux prevents mitochondrial dysfunction, and suppresses caspase-3-, apoptosis-inducing factor-, and endonuclease G-mediated constitutive apoptosis in human neutrophils.
Cellular signalling
El Kebir D,József L,Khreiss T,Filep JG
MA5-11869 was used in western blot to study whether prevention of K(+) efflux could affect the apoptotic machinery in human neutrophils
Fri Dec 01 00:00:00 UTC 2006
Stellettin A induces oxidative stress and apoptosis in HL-60 human leukemia and LNCaP prostate cancer cell lines.
Journal of natural products
Liu WK,Cheung FW,Che CT
MA5-11869 was used in western blot to investigate the effect of stellettin A on oxidative cell death
Thu Jun 01 00:00:00 UTC 2006
Overexpression of EIF3S3 promotes cancer cell growth.
The Prostate
Savinainen KJ,Helenius MA,Lehtonen HJ,Visakorpi T
MA5-11869 was used in western blot to investigate the impact of EIF3S3 on cancer cell growth
Tue Aug 01 00:00:00 UTC 2006
Opposite effects of PSD-95 and MPP3 PDZ proteins on serotonin 5-hydroxytryptamine2C receptor desensitization and membrane stability.
Molecular biology of the cell
Gavarini S,Bécamel C,Altier C,Lory P,Poncet J,Wijnholds J,Bockaert J,Marin P
MA5-11869 was used in western blot to study the effects of PSD-95 and MPP3 PDZ proteins on serotonin 5-hydroxytryptamine-2C receptor desensitization and membrane stability
Wed Nov 01 00:00:00 UTC 2006
A comparison of enhanced green fluorescent protein expression induced by immediate-early cytomegalovirus (IE-CMV) and gG pseudorabies virus (gG-PRV) promoters, using pseudorabies virus amplicons as vectors.
Journal of virological methods
Muñoz AL,Prieto C,Tabarés E
MA5-11869 was used in western blot to study the expression efficiencies of the immediate-early-CMV and gG pseudorabies virus promoters in transfected mammalian cells
Fri Sep 01 00:00:00 UTC 2006
Cyclopedic protein expression analysis of cultured canine mammary gland adenocarcinoma cells from six tumours.
Research in veterinary science
Nakagawa T,Watanabe M,Ohashi E,Uyama R,Takauji S,Mochizuki M,Nishimura R,Ogawa H,Sugano S,Sasaki N
MA5-11869 was used in western blot to investigate the protein expression in canine mammary gland adenocarcinoma cells
Thu Jun 01 00:00:00 UTC 2006
Morphologic, phenotypic and functional characteristics of endothelial cells derived from human hepatic cavernous hemangioma.
Journal of vascular research
Zhang WJ,Ye LY,Wu LQ,Xin YL,Gu F,Niu JX,Yang ZH,Zhu GJ,Grau GE,Lou JN
MA5-11869 was used in western blot to study the morphological, phenotypic and functional characteristics of endothelial cells derived from human hepatic cavernous hemangioma
Thu Jan 04 00:00:00 UTC 2007
Interplay between Ku, Artemis, and the DNA-dependent protein kinase catalytic subunit at DNA ends.
The Journal of biological chemistry
Drouet J,Frit P,Delteil C,de Villartay JP,Salles B,Calsou P
MA5-11869 was used in immunoprecipitation to study the interaction of Artemis with proteins involved of the non-homologous end joining pathway
Fri Sep 22 00:00:00 UTC 2006
N-glycosylation affects the molecular organization and stability of E-cadherin junctions.
The Journal of biological chemistry
Liwosz A,Lei T,Kukuruzinska MA
MA5-11869 was used in immunocytochemistry to study the role of N-glycosylation in the molecular organization and stability of E-cadherin junctions
Fri Aug 11 00:00:00 UTC 2006
Human keratinocytes acquire cellular cytotoxicity under UV-B irradiation. Implication of granzyme B and perforin.
The Journal of biological chemistry
Hernandez-Pigeon H,Jean C,Charruyer A,Haure MJ,Titeux M,Tonasso L,Quillet-Mary A,Baudouin C,Charveron M,Laurent G
MA5-11869 was used in western blot to study the role of granzyme B and perforin in the acquisition of cellular cytotoxicity by human keratinocytes under UV-B irradiation
Fri May 12 00:00:00 UTC 2006
Dissecting the biological functions of Drosophila histone deacetylases by RNA interference and transcriptional profiling.
The Journal of biological chemistry
Foglietti C,Filocamo G,Cundari E,De Rinaldis E,Lahm A,Cortese R,Steinkühler C
MA5-11869 was used in western blot to study the biological functions of Drosophila histone deacetylases
Fri Jun 30 00:00:00 UTC 2006
Comparison of single regulated lentiviral vectors with rtTA expression driven by an autoregulatory loop or a constitutive promoter.
Nucleic acids research
Markusic D,Oude-Elferink R,Das AT,Berkhout B,Seppen J
MA5-11869 was used in western blot to study the potential of autoregulatory lentiviral vectors for thereapeutic gene delivery
Mon Apr 04 00:00:00 UTC 2005
Induction of protein oxidation by cobalt and chromium ions in human U937 macrophages.
Biomaterials
Petit A,Mwale F,Tkaczyk C,Antoniou J,Zukor DJ,Huk OL
MA5-11869 was used in western blot to study the ability of Co(2+) and Cr(3+) ions to induce protein oxidation in U937 macrophages
Fri Jul 01 00:00:00 UTC 2005
Effect of cobalt and chromium ions on MMP-1, TIMP-1, and TNF-alpha gene expression in human U937 macrophages: a role for tyrosine kinases.
Biomaterials
Luo L,Petit A,Antoniou J,Zukor DJ,Huk OL,Liu RC,Winnik FM,Mwale F
MA5-11869 was used in western blot to study the involvement of tyrosine kinases in the effects of Co(2+) and Cr(3+) on the expression of MMP-1, TIMP-1 and TNFalpha by U937 macrophages
Sat Oct 01 00:00:00 UTC 2005
RNA interference demonstrates a novel role for integrin-linked kinase as a determinant of pancreatic adenocarcinoma cell gemcitabine chemoresistance.
Clinical cancer research : an official journal of the American Association for Cancer Research
Duxbury MS,Ito H,Benoit E,Waseem T,Ashley SW,Whang EE
MA5-11869 was used in western blot to study the role of integrin-linked kinase as a determinant of pancreatic adenocarcinoma cell gemcitabine chemoresistance
Sun May 01 00:00:00 UTC 2005
HYAL1 hyaluronidase: a molecular determinant of bladder tumor growth and invasion.
Cancer research
Lokeshwar VB,Cerwinka WH,Lokeshwar BL
MA5-11869 was used in western blot to investigate the role of HYAL1 hyaluronidase in bladder tumor growth and metastases
Tue Mar 15 00:00:00 UTC 2005
Stable RNA interference-mediated suppression of cyclophilin A diminishes non-small-cell lung tumor growth in vivo.
Cancer research
Howard BA,Furumai R,Campa MJ,Rabbani ZN,Vujaskovic Z,Wang XF,Patz EF
MA5-11869 was used in western blot to study the effect of RNA-mediated suppression of cyclophilin A on non-small-cell lung tumor growth in vivo
Sat Oct 01 00:00:00 UTC 2005
The effect of isoforms of the cell polarity protein, human ASIP, on the cell cycle and Fas/FasL-mediated apoptosis in human hepatoma cells.
Cellular and molecular life sciences : CMLS
Hu Y,Fang C,Xu Y
MA5-11869 was used in western blot to study the effect of isoforms of the cell polarity protein, human ASIP, on the cell cycle and Fas/FasL-mediated apoptosis in human hepatoma cells
Thu Sep 01 00:00:00 UTC 2005
Gene regulation profile reveals consistent anticancer properties of progesterone in hormone-independent breast cancer cells transfected with progesterone receptor.
International journal of cancer
Leo JC,Wang SM,Guo CH,Aw SE,Zhao Y,Li JM,Hui KM,Lin VC
MA5-11869 was used in western blot to study the anti-tumor activity of progesterone in hormone-independent breast cancer cells
Sun Nov 20 00:00:00 UTC 2005
Effect of glycine on recovery of bladder smooth muscle contractility after acute urinary retention in rats.
BJU international
Hong SK,Son H,Kim SW,Oh SJ,Choi H
MA5-11869 was used in western blot to study whether glycine ia able to promote urinary bladder smooth muscle contractility following acute urinary retention in a rat model
Thu Dec 01 00:00:00 UTC 2005
Evidence for specific TRPM8 expression in human prostate secretory epithelial cells: functional androgen receptor requirement.
Endocrine-related cancer
Bidaux G,Roudbaraki M,Merle C,Crépin A,Delcourt P,Slomianny C,Thebault S,Bonnal JL,Benahmed M,Cabon F,Mauroy B,Prevarskaya N
MA5-11869 was used in western blot to study TRPM8 expression in human prostate secretory epithelial cells
Wed Jun 01 00:00:00 UTC 2005
Phosphorylation of BLM, dissociation from topoisomerase IIIalpha, and colocalization with gamma-H2AX after topoisomerase I-induced replication damage.
Molecular and cellular biology
Rao VA,Fan AM,Meng L,Doe CF,North PS,Hickson ID,Pommier Y
MA5-11869 was used in western blot to study the role of the Bloom's syndrome protein in the signaling response to Top1-mediated replication DNA damage
Sat Oct 01 00:00:00 UTC 2005
Protein kinase C zeta associates with death inducing signaling complex and regulates Fas ligand-induced apoptosis.
Cellular signalling
Leroy I,de Thonel A,Laurent G,Quillet-Mary A
MA5-11869 was used in western blot to study whether PKC-zeta targets apical events of Fas signaling using Jurkat cells as a FasL-sensitive human T-cell model
Thu Sep 01 00:00:00 UTC 2005
Histone H4 post-translational modifications in chordate mitotic and endoreduplicative cell cycles.
Journal of cellular biochemistry
Spada F,Chioda M,Thompson EM
MA5-11869 was used in western blot to investigate histone H4 post-translational modifications during mitotic and endocycles of Oikopleura dioica in comparison with those in mitotic cycle of proliferating mammalian cells
Mon Aug 01 00:00:00 UTC 2005
Melatonin reduces prostate cancer cell growth leading to neuroendocrine differentiation via a receptor and PKA independent mechanism.
The Prostate
Sainz RM,Mayo JC,Tan DX,León J,Manchester L,Reiter RJ
MA5-11869 was used in western blot to study the mechanisms by which melatonin inhibits prostate cancer cell growth and induces neuroendocrine differentiation
Fri Apr 01 00:00:00 UTC 2005
Role of La autoantigen and polypyrimidine tract-binding protein in HCV replication.
Virology
Domitrovich AM,Diebel KW,Ali N,Sarker S,Siddiqui A
MA5-11869 was used in western blot to study the role of La autoantigen and polypyrimidine tract-binding protein in HCV replication
Mon Apr 25 00:00:00 UTC 2005
Atypical endometrial stromal cells related with a polypoid leiomyoma with bizarre nuclei: a case report.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
Usubütün A,Karaman N,Ayhan A,Küçükali T
MA5-11869 was used in immunohistochemistry to report on a case of atypical endometrial stromal cells related to a polypoid leiomyoma with bizarre nuclei
Sat Oct 01 00:00:00 UTC 2005
Oleuropein, a non-toxic olive iridoid, is an anti-tumor agent and cytoskeleton disruptor.
Biochemical and biophysical research communications
Hamdi HK,Castellon R
MA5-11869 was used in immunocytochemistry to study the anti-tumor and cytoskeletal disruptive activity of the non-toxic olive iridoid Oleuropein
Fri Sep 02 00:00:00 UTC 2005
TFAR19 gene changes the biophysical properties of murine erythroleukemia cells.
Cell biochemistry and biophysics
Gu L,Jiang Y,Wang Y,Yao W,Sun D,Ka W,Tang Z,Xu X,Wen Z,Chien S
MA5-11869 was used in western blot to study the effects of the apoptosis-related gene TFAR19 on mouse erythroleukemia cells and the mechanisms involved
Tue Feb 21 00:00:00 UTC 2006
Proteolytic processing of TGFalpha redirects its mitogenic activity: the membrane-anchored form is autocrine, the secreted form is paracrine.
Biochimica et biophysica acta
Roh M,Paterson AJ,Liu K,McAndrew J,Chin E,Kudlow JE
MA5-11869 was used in immunohistochemistry to study the role of proteolytic processing in converting autocrine membrane-bound TGFalpha into paracrine soluble TGFalpha
Fri Apr 15 00:00:00 UTC 2005
EphA2 as a glioma-associated antigen: a novel target for glioma vaccines.
Neoplasia (New York, N.Y.)
Hatano M,Eguchi J,Tatsumi T,Kuwashima N,Dusak JE,Kinch MS,Pollack IF,Hamilton RL,Storkus WJ,Okada H
MA5-11869 was used in western blot to study the potential of an EphA2 epitope as the basis for a molecularly targeted anti-glioma vacccine
Mon Aug 01 00:00:00 UTC 2005
Regenerative and fibrotic pathways in canine hepatic portosystemic shunt and portal vein hypoplasia, new models for clinical hepatocyte growth factor treatment.
Comparative hepatology
Spee B,Penning LC,van den Ingh TS,Arends B,Ijzer J,van Sluijs FJ,Rothuizen J
MA5-11869 was used in western blot to study two spontaneous diseases of the dog liver as potential simplified models of HGF treatment
Wed Dec 07 00:00:00 UTC 2005
Hsp70 inhibits heat-induced apoptosis upstream of mitochondria by preventing Bax translocation.
The Journal of biological chemistry
Stankiewicz AR,Lachapelle G,Foo CP,Radicioni SM,Mosser DD
MA5-11869 was used in western blot to study the ability of HSP70 overexpression to block Bax tranlocation and inhibit heat-induced apoptosis upstream of mitochondrial disruption
Fri Nov 18 00:00:00 UTC 2005
Novel role of cold/menthol-sensitive transient receptor potential melastatine family member 8 (TRPM8) in the activation of store-operated channels in LNCaP human prostate cancer epithelial cells.
The Journal of biological chemistry
Thebault S,Lemonnier L,Bidaux G,Flourakis M,Bavencoffe A,Gordienko D,Roudbaraki M,Delcourt P,Panchin Y,Shuba Y,Skryma R,Prevarskaya N
MA5-11869 was used in western blot to study the role of the cold/menthol-sensitive TRPM8 channel in Ca(2+) metabolism in human prostate cancer epithelial cells
Fri Nov 25 00:00:00 UTC 2005
Systemic siRNA-mediated gene silencing: a new approach to targeted therapy of cancer.
Annals of surgery
Duxbury MS,Matros E,Ito H,Zinner MJ,Ashley SW,Whang EE
MA5-11869 was used in western blot to study the therapeutic potential of systemic siRNA gene knockdown in a mouse pancreatic adenocarcinoma xenograft model
Fri Oct 01 00:00:00 UTC 2004
Prostaglandin E2 enhances pancreatic cancer invasiveness through an Ets-1-dependent induction of matrix metalloproteinase-2.
Cancer research
Ito H,Duxbury M,Benoit E,Clancy TE,Zinner MJ,Ashley SW,Whang EE
MA5-11869 was used in western blot to study the involvement of Ets-1 and MMP-2 in the mechanism by which PHE2 promotes the invasiveness of pancreatic cancer cells
Fri Oct 15 00:00:00 UTC 2004
The Kaposi's sarcoma-associated herpesvirus K-bZIP protein represses transforming growth factor beta signaling through interaction with CREB-binding protein.
Oncogene
Tomita M,Choe J,Tsukazaki T,Mori N
MA5-11869 was used in western blot to study the mechanism by which Kaposi's sarcoma-associated herpesvirus K-bZIP protein represses TGF-beta signaling
Thu Oct 28 00:00:00 UTC 2004
CEACAM6 gene silencing impairs anoikis resistance and in vivo metastatic ability of pancreatic adenocarcinoma cells.
Oncogene
Duxbury MS,Ito H,Zinner MJ,Ashley SW,Whang EE
MA5-11869 was used in western blot to study the effects CEACAM6 gene silencing on anoikis and metastasis of human pancreatic adenocarcinoma cells
Thu Jan 15 00:00:00 UTC 2004
Elevated expression of CCL5/RANTES in adult T-cell leukemia cells: possible transactivation of the CCL5 gene by human T-cell leukemia virus type I tax.
International journal of cancer
Mori N,Krensky AM,Ohshima K,Tomita M,Matsuda T,Ohta T,Yamada Y,Tomonaga M,Ikeda S,Yamamoto N
MA5-11869 was used in western blot to study the role of HTLV-1 tax in the elevated levels of CCL5/RANTES production observed in adult T-cell leukemia
Fri Sep 10 00:00:00 UTC 2004
Transient adenoviral N-methylpurine DNA glycosylase overexpression imparts chemotherapeutic sensitivity to human breast cancer cells.
Molecular cancer therapeutics
Rinne M,Caldwell D,Kelley MR
MA5-11869 was used in western blot to study the ability of transient transfection with N-methylpurine DNA glycosylase to sensitize human breast cancer cells to alkylating agents
Sun Aug 01 00:00:00 UTC 2004
Involvement of extracellular signal-regulated kinase/mitogen-activated protein kinase pathway in multidrug resistance induced by HBx in hepatoma cell line.
World journal of gastroenterology
Guan J,Chen XP,Zhu H,Luo SF,Cao B,Ding L
MA5-11869 was used in western blot to investigate the role of HBx protein on the occurrence of multidrug resistance in hepatoma cell line
Wed Dec 01 00:00:00 UTC 2004
Organ-specific stress induces mouse pancreatic keratin overexpression in association with NF-kappaB activation.
Journal of cell science
Zhong B,Zhou Q,Toivola DM,Tao GZ,Resurreccion EZ,Omary MB
MA5-11869 was used in western blot to study NFkappaB activation and pancreatic keratin overexpresssion in response to organ-specific stress
Thu Apr 01 00:00:00 UTC 2004
Focal adhesion kinase gene silencing promotes anoikis and suppresses metastasis of human pancreatic adenocarcinoma cells.
Surgery
Duxbury MS,Ito H,Zinner MJ,Ashley SW,Whang EE
MA5-11869 was used in western blot to study the effects of focal adhesion kinase knockdown on anoikis and metastasis of human pancreatic adenocarcinoma cells
Sat May 01 00:00:00 UTC 2004
Prenatal estrogen exposure differentially affects estrogen receptor-associated proteins in rat testis gonocytes.
Biology of reproduction
Wang Y,Thuillier R,Culty M
MA5-11869 was used in western blot to study the effect of prenatal estrogen exposure on the expression of proteins associated with the estrogen receptor in rat testis gonocytes
Mon Nov 01 00:00:00 UTC 2004
The T-cell protein tyrosine phosphatase is phosphorylated on Ser-304 by cyclin-dependent protein kinases in mitosis.
The Biochemical journal
Bukczynska P,Klingler-Hoffmann M,Mitchelhill KI,Lam MH,Ciccomancini M,Tonks NK,Sarcevic B,Kemp BE,Tiganis T
MA5-11869 was used in western blot to study the cell cycle-dependent phosphorylation of T-cell protein tyrosine phosphatase by cyclin-dependent protein kinases
Tue Jun 15 00:00:00 UTC 2004
Ligation of EphA2 by Ephrin A1-Fc inhibits pancreatic adenocarcinoma cellular invasiveness.
Biochemical and biophysical research communications
Duxbury MS,Ito H,Zinner MJ,Ashley SW,Whang EE
MA5-11869 was used in western blot to study the effect of EphA2 overexpression and ligation by chimeric Ephrin A1-Fc on the invasive phenotype of pancreatic adenocarcinoma cells
Fri Aug 06 00:00:00 UTC 2004
CEACAM6 cross-linking induces caveolin-1-dependent, Src-mediated focal adhesion kinase phosphorylation in BxPC3 pancreatic adenocarcinoma cells.
The Journal of biological chemistry
Duxbury MS,Ito H,Ashley SW,Whang EE
MA5-11869 was used in western blot to study the effects of cross-linking the GPI-anchored protein CEACAM6 on intracellular signaling and anchorage-independent survival of a pancreatic adenocarcinoma cell line
Fri May 28 00:00:00 UTC 2004
Possible anti-recombinogenic role of Bloom's syndrome helicase in double-strand break processing.
Nucleic acids research
Onclercq-Delic R,Calsou P,Delteil C,Salles B,Papadopoulo D,Amor-Guéret M
MA5-11869 was used in immunoprecipitation to study the potential anti-recombinogenic role of BLM DNA helicase in double-strand break processing
Sat Nov 01 00:00:00 UTC 2003
The DNA-bending protein HMGB1 is a cellular cofactor of Sleeping Beauty transposition.
Nucleic acids research
Zayed H,Izsvák Z,Khare D,Heinemann U,Ivics Z
MA5-11869 was used in immunoprecipitation to study the role of the DNA-bending protein HMGB1 in Sleeping Beauty transposition
Thu May 01 00:00:00 UTC 2003
Expression of cyclin-dependent kinase 6, but not cyclin-dependent kinase 4, alters morphology of cultured mouse astrocytes.
Molecular cancer research : MCR
Ericson KK,Krull D,Slomiany P,Grossel MJ
MA5-11869 was used in western blot to study the functional differences of CDK4 and CDK6 in cultured murine astrocytes
Tue Jul 01 00:00:00 UTC 2003
Coordinated assembly of Ku and p460 subunits of the DNA-dependent protein kinase on DNA ends is necessary for XRCC4-ligase IV recruitment.
Journal of molecular biology
Calsou P,Delteil C,Frit P,Drouet J,Salles B
MA5-11869 was used in immunoprecipitation to investigate the relationship and assembly of specific proteins during DNA repair process
Fri Feb 07 00:00:00 UTC 2003
Human MDR1 polymorphism: G2677T/A and C3435T have no effect on MDR1 transport activities.
Biochemical pharmacology
Morita N,Yasumori T,Nakayama K
MA5-11869 was used in western blot to study whether the two most common SNPs of the human MDR1 gene have any effect on its transport functionality
Sun Jun 01 00:00:00 UTC 2003
Keratin-8 null mice have different gallbladder and liver susceptibility to lithogenic diet-induced injury.
Journal of cell science
Tao GZ,Toivola DM,Zhong B,Michie SA,Resurreccion EZ,Tamai Y,Taketo MM,Omary MB
MA5-11869 was used in western blot to study the differential susceptibility of gallbladder and liver to damage in keratin-8 null mice exposed to a high fat lithogenic diet
Sat Nov 15 00:00:00 UTC 2003
Measles virus-induced modulation of host-cell gene expression.
The Journal of general virology
Bolt G,Berg K,Blixenkrone-Møller M
MA5-11869 was used in western blot to study measles virus-induced modulation of host-cell gene expression by human peripheral blood mononuclear cells
Wed May 01 00:00:00 UTC 2002
