Invitrogen

Activin A Recombinant Rabbit Monoclonal Antibody (21H15L7)

View all (25) Activin A antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

702177

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

2 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

Expi293

Class

Recombinant Monoclonal

Type

Antibody

Clone

21H15L7

Immunogen

Peptides corresponding to Human INHBA (aa 262-279, 407-423)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2633063

Product Specific Information

This antibody is predicted to react with Monkey, Bovine, Sheep and Goat

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Activin A mutations are associated with fibrodysplasia ossificans progressive.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Activin beta-A chain; EDF; erythroid differentiation factor; Erythroid differentiation protein; follicle-stimulating hormone-releasing protein; FSH-releasing protein; Inhibin beta A chain; inhibin, beta A (activin A, activin AB alpha polypeptide); Inhibin, beta-1

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Gene Aliases: EDF; FRP; INHBA

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UniProt ID: (Human) P08476

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Entrez Gene ID: (Human) 3624

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Function(s)
cytokine activity transforming growth factor beta receptor binding hormone activity protein binding growth factor activity peptide hormone binding inhibin binding identical protein binding protein heterodimerization activity type II activin receptor binding
Process(es)
G1/S transition of mitotic cell cycle ovarian follicle development hair follicle development hematopoietic progenitor cell differentiation regulation of transcription from RNA polymerase II promoter defense response cell cycle arrest cell surface receptor signaling pathway cell-cell signaling nervous system development negative regulation of cell proliferation male gonad development positive regulation of gene expression positive regulation of pathway-restricted SMAD protein phosphorylation striatal medium spiny neuron differentiation cell differentiation erythrocyte differentiation negative regulation of cell growth positive regulation of cellular protein metabolic process activin receptor signaling pathway endodermal cell differentiation growth negative regulation of phosphorylation odontogenesis response to drug hemoglobin biosynthetic process progesterone secretion regulation of MAPK cascade negative regulation of interferon-gamma biosynthetic process negative regulation of B cell differentiation positive regulation of erythrocyte differentiation negative regulation of macrophage differentiation negative regulation of cell cycle positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of follicle-stimulating hormone secretion positive regulation of follicle-stimulating hormone secretion negative regulation of follicle-stimulating hormone secretion mesodermal cell differentiation cell development palate development positive regulation of ovulation SMAD protein signal transduction eyelid development in camera-type eye cellular response to follicle-stimulating hormone stimulus cellular response to cholesterol GABAergic neuron differentiation extrinsic apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
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