Proteintech

Adenosine A1 Receptor Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

20332-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500
-

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Adenosine A1 Receptor Fusion Protein Ag14092 (184-243 aa encoded by BC026340)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.15 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: NFFVWVLPP LLLMVLIYLE VFYLIRKQLN KKVSASSGDP QKYYGKELKI AKSLALILFL F (184-243 aa encoded by BC026340)

Target Information

Adenosine receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily. Structural, biochemical and pharmacological analyses of the AR genes and protein has led to the discovery of four distinct AR subtypes (A1, A2a, A2b, A3). Activation of ARs mediates several receptor subtype-specific physiological processes that include cardiac rate, smooth muscle tone, platelet aggregation, inflammation, cell growth and death, and neurotransmission. The A1AR is a glycoprotein that can activate Gi and Go proteins in vitro. In intact cells, agonist occupation of the A1AR has been shown to cause pertussis toxin-sensitive inhibition of adenylyl cyclase activity and, in some systems, a stimulation of phospholipase C resulting in mobilization of intracellular calcium stores. Activation of potassium channels by A1AR has been intensively studied in relation to its dramatic effects on the cardiovascular system. A1AR protein is highly expressed in brain (especially cerebellum, hippocampus, thalamus, and cortex) and spinal cord and in part, modulates neurotransmitter release. In white adipocytes A1AR inhibits lipolysis and stimulates glucose uptake. Other tissues also express A1AR including kidney and testis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: adenosine A1 receptor variant 1; adenosine A1 receptor variant 2; Adenosine receptor A1; ADO-A1 receptor; AR

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Gene Aliases: A1-AR; A1AR; A1R; AA1R; ADORA1; AI848715; BB176431; RDC7; Ri

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UniProt ID: (Human) P30542, (Mouse) Q60612

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Entrez Gene ID: (Human) 134, (Mouse) 11539

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Function(s)
G-protein coupled adenosine receptor activity G-protein coupled receptor binding purine nucleoside binding phospholipase C activity protein binding heat shock protein binding G-protein beta/gamma-subunit complex binding heterotrimeric G-protein binding protein heterodimerization activity signal transducer activity G-protein coupled receptor activity
Process(es)
activation of MAPKK activity temperature homeostasis response to hypoxia adenosine receptor signaling pathway regulation of respiratory gaseous exchange by neurological system process negative regulation of acute inflammatory response negative regulation of leukocyte migration positive regulation of peptide secretion regulation of glomerular filtration protein targeting to membrane phagocytosis inflammatory response signal transduction adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway cell-cell signaling nervous system development negative regulation of cell proliferation negative regulation of glutamate secretion lipid catabolic process negative regulation of synaptic transmission, GABAergic positive regulation of nucleoside transport negative regulation of neurotrophin production positive regulation of protein dephosphorylation negative regulation of renal sodium excretion negative regulation of circadian sleep/wake cycle, non-REM sleep negative regulation of apoptotic process positive regulation of potassium ion transport positive regulation of epidermal growth factor-activated receptor activity negative regulation of blood pressure positive regulation of blood pressure negative regulation of vasodilation negative regulation of hormone secretion cognition detection of temperature stimulus involved in sensory perception of pain negative regulation of lipid catabolic process regulation of sensory perception of pain negative regulation of synaptic transmission, glutamatergic negative regulation of cardiac muscle contraction excitatory postsynaptic potential relaxation of vascular smooth muscle negative regulation of mucus secretion apoptotic signaling pathway negative regulation of long term synaptic depression G-protein coupled receptor signaling pathway negative regulation of circadian sleep/wake cycle, sleep negative regulation of heart contraction regulation of synaptic plasticity negative regulation of inflammatory response regulation of cardiac muscle contraction
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