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Proteintech
Adrenomedullin Polyclonal Antibody
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Product Details
10778-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Adrenomedullin Fusion Protein Ag1197 (1-185 aa encoded by BC015961)
Conjugate
Form
Liquid
Concentration
0.35 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MKLVSVALM YLGSLAFLGA DTARLDVASE FRKKWNKWAL SRGKRELRMS SSYPTGLADV KAGPAQTLIR PQDMKGASRS PEDSSPDAAR IRVKRYRQSM NNFQGLRSFG CRFGTCTVQK LAHQIYQFTD KDKDNVAPRS KISPQGYGRR RRRSLPEAGP GRTLVSSKPQ AHGAPAPPSG SAPHFL (1-185 aa encoded by B C015961)
Target Information
Adrenomedullin (ADM), a vasodilator produced by most contractile cells, is characterized by persistent hypotensive activity. ADM is involved in the regulation of fluid and electrolyte homeostasis and in the maintenance of cardiovascular functioning. In hypertensive patients, the level of ADM in plasma is upregulated. Natriuresis is a common systemic manifestation of aneurysmal subarachnoid hemorrhage. ADM has strong natriuretic actions. ADM-induced natriuresis is caused by an increase in glomerular filtration rate and a decrease in distal tubular sodium reabsorption. ADM is present both in the periphery and brain, and can exert central effects such as decreasing food ingestion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: AMpreproadrenomedullin; preproadrenomedullin; Pro-adrenomedullin; proadrenomedullin N-20 terminal peptide; ProAM-N20
Gene Aliases: ADM; AM; PAMP
UniProt ID: (Human) P35318
Entrez Gene ID: (Human) 133
vasculogenesis
response to hypoxia
neural tube closure
response to yeast
regulation of the force of heart contraction
G-protein coupled receptor internalization
cAMP biosynthetic process
progesterone biosynthetic process
signal transduction
positive regulation of cytosolic calcium ion concentration
cell-cell signaling
heart development
female pregnancy
aging
blood circulation
androgen metabolic process
positive regulation of cell proliferation
negative regulation of cell proliferation
response to cold
response to wounding
positive regulation of heart rate
antibacterial humoral response
antifungal humoral response
cAMP-mediated signaling
positive regulation of cAMP biosynthetic process
organ regeneration
neuron projection regeneration
receptor internalization
response to lipopolysaccharide
response to insulin
odontogenesis of dentin-containing tooth
response to starvation
positive regulation of apoptotic process
negative regulation of vascular permeability
positive regulation of angiogenesis
negative regulation of vasoconstriction
positive regulation of vasodilation
hormone secretion
developmental growth
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
response to glucocorticoid
branching involved in labyrinthine layer morphogenesis
spongiotrophoblast layer development
vascular smooth muscle cell development
positive regulation of vasculogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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