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AbboMax
Aggrecan/AGC1 Polyclonal Antibody
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Aggrecan/AGC1 Antibody (600-670) in WB
Western Blot: The tissue lysate derived from mouse embryonic tisse was resolved onto 7.5% SDS-PAGE, transferred onto NC membrane, and immunoprobed by Rabbit anti Aggrecan (Cat#600-670) at 1:500. multiple immunoreactive bands ~above 100 kDa was observed.
Product Details
600-670
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to the 380-400 aa of human ACAN protein
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with proprietary stabilizer
Contains
0.01% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Positive control: Mouse embryonic tissue
Cellular location: Extra cellular, Membrane.
Target Information
Aggrecan also known as cartilage-specific proteoglycan core protein (CSPCP) or chondroitin sulfate proteoglycan 1 is a protein that is encoded by the ACAN gene. The encoded protein is an integral part of the extracellular matrix in cartilaginous tissue and it withstands compression in cartilage. The human form of the protein is 2316 amino acids long (approximately 250 kDa) and can be expressed in multiple isoforms due to alternative splicing. Aggrecan exhibits a bottlebrush structure, in which chondroitin sulfate and keratan sulfate chains are attached to an extended protein core. The synthesis and degradation of aggrecan are being investigated for their roles in cartilage deterioration during joint injury, disease, and aging. It contains three interglobular domains (IGDs), G1, G2, and G3 that are involved in aggregation, hyaluronan binding, cell adhesion, and chondrocyte apoptosis. Aggrecan fragments from articular cartilage are released into the synovial fluid at all stages of human osteoarthritis as a result of cleavage by aggrecanase and MMP activity. Antibodies BC-3 and BC-4 can be used to detect these neo epitopes of Aggrecanase (ARGSVXXX) and MMP (XXXVDIPEN), respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: aggrecan 1; Aggrecan core protein; aggrecan, structural proteoglycan of cartilage; Cartilage-specific proteoglycan core protein; Chondroitin sulfate proteoglycan 1; Chondroitin sulfate proteoglycan core protein 1; CSPCP; large aggregating proteoglycan
Gene Aliases: ACAN; Agc; AGC1; AGCAN; b2b183Clo; cmd; CSPG1; CSPGCP; MSK16; SEDK
UniProt ID: (Human) P16112, (Rat) P07897, (Mouse) Q61282
Entrez Gene ID: (Human) 176, (Rat) 58968, (Mouse) 11595
cartilage condensation
ossification
chondrocyte development
cell adhesion
central nervous system development
response to radiation
response to mechanical stimulus
response to gravity
response to glucose
multicellular organism aging
response to acidic pH
response to organic cyclic compound
spinal cord development
proteoglycan biosynthetic process
collagen fibril organization
negative regulation of cell migration
response to drug
chondroblast differentiation
cellular response to growth factor stimulus
skeletal system development
proteolysis
keratan sulfate biosynthetic process
extracellular matrix disassembly
extracellular matrix organization
keratan sulfate catabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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