Product References
Autologous and Allogeneic Cytotherapies for Large Knee (Osteo)Chondral Defects: Manufacturing Process Benchmarking and Parallel Functional Qualification.
Pharmaceutics
Philippe V,Jeannerat A,Peneveyre C,Jaccoud S,Scaletta C,Hirt-Burri N,Abdel-Sayed P,Raffoul W,Darwiche S,Applegate LA,Martin R,Laurent A
AHP0022 was used in Immunohistochemistry to comparatively assess autologous and allogeneic approaches (quality, safety, functional attributes) to cell-based knee chondrotherapies developed for clinical use.
Sat Sep 16 00:00:00 UTC 2023
Characterization of Migratory Cells From Bioengineered Bovine Cartilage in a 3D Co-culture Model.
The American journal of sports medicine
Wu MJM,Sermer C,Kandel RA,Theodoropoulos JS
Published figure using Aggrecan monoclonal antibody (Product # AHP0022) in Immunohistochemistry
Thu Sep 01 00:00:00 UTC 2022
Associations Between Physical Activity, Self-reported Joint Function, and Molecular Biomarkers in Working Age Individuals With Hip and/or Knee Osteoarthritis.
Clinical medicine insights. Arthritis and musculoskeletal disorders
Östlind E,Eek F,Stigmar K,Sant'Anna A,Ekvall Hansson E,Struglics A
AHP0022 was used in Functional assay to explore the associations between PA or self-reported joint function and molecular biomarkers.
Sun Aug 25 00:00:00 UTC 2024
Biological variation of human aggrecan ARGS neoepitope in synovial fluid and serum in early-stage knee osteoarthritis and after knee injury.
Osteoarthritis and cartilage open
Larsson S,Lohmander LS,Struglics A
AHP0022 was used in ELISA, Immunohistochemistry, Western Blot, In Vitro Assay to demonstrate that biological variation of ARGS is lower in serum than in synovial fluid, and lower in OA than after ACL injury.
Thu Dec 01 00:00:00 UTC 2022
Utility of direct 3D co-culture model for chondrogenic differentiation of mesenchymal stem cells on hyaluronan scaffold (Hyaff-11).
Regenerative biomaterials
Deszcz I,Lis-Nawara A,Grelewski P,Dragan S,Bar J
AHP0022 was used in Immunohistochemistry to presents direct 2D and 3D co-culture model of mesenchymal stem cells (MSCs) line with chondrocytes isolated from patients with osteoarthritis (unaffected area).
Tue Dec 01 00:00:00 UTC 2020
Utility of direct 3D co-culture model for chondrogenic differentiation of mesenchymal stem cells on hyaluronan scaffold (Hyaff-11).
Regenerative biomaterials
Deszcz I,Lis-Nawara A,Grelewski P,Dragan S,Bar J
AHP0022 was used in Immunohistochemistry to presents direct 2D and 3D co-culture model of mesenchymal stem cells (MSCs) line with chondrocytes isolated from patients with osteoarthritis (unaffected area).
Tue Dec 01 00:00:00 UTC 2020
Platelet-rich plasma enhances the integration of bioengineered cartilage with native tissue in an in vitro model.
Journal of tissue engineering and regenerative medicine
Sermer C,Kandel R,Anderson J,Hurtig M,Theodoropoulos J
AHP0022 was used in Immunohistochemistry to suggest that PRP-soaked bioengineered cartilage implants may be a better approach for cartilage repair due to enhanced integration.
Thu Feb 01 00:00:00 UTC 2018
Surgical reconstruction of ruptured anterior cruciate ligament prolongs trauma-induced increase of inflammatory cytokines in synovial fluid: an exploratory analysis in the KANON trial.
Osteoarthritis and cartilage
Larsson S,Struglics A,Lohmander LS,Frobell R
AHP0022 was used in Immuno-assay to monitor how treatment of acutely ruptured anterior cruciate ligament (ACL) affects biomarkers of inflammation and proteolytic degradation.
Fri Sep 01 00:00:00 UTC 2017
Formation of Hyaline Cartilage Tissue by Passaged Human Osteoarthritic Chondrocytes.
Tissue engineering. Part A
Bianchi VJ,Weber JF,Waldman SD,Backstein D,Kandel RA
AHP0022 was used in immunohistochemistry - frozen section to test if TGF-beta supplementation stimulates chondrocyte redifferentiation
Wed Feb 01 00:00:00 UTC 2017
ESTABLISHING A LIVE CARTILAGE-ON-CARTILAGE INTERFACE FOR TRIBOLOGICAL TESTING.
Biotribology (Oxford)
Trevino RL,Stoia J,Laurent MP,Pacione CA,Chubinskaya S,Wimmer MA
Published figure using Aggrecan monoclonal antibody (Product # AHP0022) in Western Blot
Wed Mar 01 00:00:00 UTC 2017
Generating Mechanically Stable, Pediatric, and Scaffold-Free Nasal Cartilage Constructs In Vitro.
Tissue engineering. Part C, Methods
Akbari P,Waldman SD,Propst EJ,Cushing SL,Weber JF,Yeger H,Farhat WA
AHP0022 was used in immunohistochemistry - paraffin section to generate and characterize bioreactor-cultivated nasal cartilage constructs
Thu Dec 01 00:00:00 UTC 2016
Translational development of an ADAMTS-5 antibody for osteoarthritis disease modification.
Osteoarthritis and cartilage
Larkin J,Lohr TA,Elefante L,Shearin J,Matico R,Su JL,Xue Y,Liu F,Genell C,Miller RE,Tran PB,Malfait AM,Maier CC,Matheny CJ
AHP0022 was used in blocking or activating experiment to assess the therapeutic use of monoclonal antibodies to ADAMTS-5 and ADAMTS-4 in pathogenic cartilage degradation
Sat Aug 01 00:00:00 UTC 2015
Inflammatory cytokines and biomarkers of cartilage metabolism 8 years after anterior cruciate ligament reconstruction: results from operated and contralateral knees.
The American journal of sports medicine
Åhlén M,Roshani L,Lidén M,Struglics A,Rostgård-Christensen L,Kartus J
AHP0022 was used in immunocytochemistry to discuss the role of inflammation in posttraumatic arthritis
Mon Jun 01 00:00:00 UTC 2015
Poly(γ-Glutamic Acid) as an Exogenous Promoter of Chondrogenic Differentiation of Human Mesenchymal Stem/Stromal Cells.
Tissue engineering. Part A
Antunes JC,Tsaryk R,Gonçalves RM,Pereira CL,Landes C,Brochhausen C,Ghanaati S,Barbosa MA,Kirkpatrick CJ
AHP0022 was used in immunohistochemistry - paraffin section to examine the ability of gamma-PGA to support production of cartilaginous extracellular matrix.
Mon Jun 01 00:00:00 UTC 2015
The importance of connexin hemichannels during chondroprogenitor cell differentiation in hydrogel versus microtissue culture models.
Tissue engineering. Part A
Schrobback K,Klein TJ,Woodfield TB
AHP0022 was used in immunocytochemistry to examine the influence of gap junction-mediated cell-cell communication on chondrogenesis of bone marrow-derived mesenchymal stromal cells and articular chondrocytes.
Mon Jun 01 00:00:00 UTC 2015
An ARGS-aggrecan assay for analysis in blood and synovial fluid.
Osteoarthritis and cartilage
Larsson S,Lohmander LS,Struglics A
AHP0022 was used in immunoprecipitation to evaludate a novel ARGS-aggrecan assay.
Sat Feb 01 00:00:00 UTC 2014
Physiological testosterone levels enhance chondrogenic extracellular matrix synthesis by male intervertebral disc cells in vitro, but not by mesenchymal stem cells.
The spine journal : official journal of the North American Spine Society
Bertolo A,Baur M,Aebli N,Ferguson SJ,Stoyanov J
AHP0022 was used in immunohistochemistry - frozen section to study the effect of testosterone on intervertebral disc.
Sat Mar 01 00:00:00 UTC 2014
Biochemical and structural characterization of neocartilage formed by mesenchymal stem cells in alginate hydrogels.
PloS one
Olderøy MØ,Lilledahl MB,Beckwith MS,Melvik JE,Reinholt F,Sikorski P,Brinchmann JE
AHP0022 was used in immunohistochemistry - paraffin section to study how mesencymal stem cells in alginate hydrogels can form neocartilage in regards to biochemical and structural characterization
Thu Jan 14 00:00:00 UTC 2016
Degenerated human intervertebral discs contain autoantibodies against extracellular matrix proteins.
European cells & materials
Capossela S,Schläfli P,Bertolo A,Janner T,Stadler BM,Pötzel T,Baur M,Stoyanov JV
AHP0022 was used in western blot to study the association between disc degeneration and autoimmunity
Fri Apr 04 00:00:00 UTC 2014
Hyaluronic acid enhances the mechanical properties of tissue-engineered cartilage constructs.
PloS one
Levett PA,Hutmacher DW,Malda J,Klein TJ
AHP0022 was used in immunohistochemistry - frozen section to study the mechanical properties of tissue-engineered cartilage constructs using in vitro culture models incorporating human chondrocytes from osteoarthritis patients
Mon Sep 21 00:00:00 UTC 2015
Similar properties of chondrocytes from osteoarthritis joints and mesenchymal stem cells from healthy donors for tissue engineering of articular cartilage.
PloS one
Fernandes AM,Herlofsen SR,Karlsen TA,Küchler AM,Fløisand Y,Brinchmann JE
AHP0022 was used in immunocytochemistry to test if osteoarthritis chondrocytes are suitable for tissue engineering of articular cartilage.
Tue Dec 24 00:00:00 UTC 2013
The cartilage matrix molecule components produced by human foetal cartilage rudiment cells within scaffolds and the role of exogenous growth factors.
Biomaterials
Chuang CY,Shahin K,Lord MS,Melrose J,Doran PM,Whitelock JM
AHP0022 was used in immunohistochemistry (paraffin) to generate a three-dimensional cartilage scaffold and incorporate fetal cartilage rudiment cells.
Fri Jun 01 00:00:00 UTC 2012
The association between changes in synovial fluid levels of ARGS-aggrecan fragments, progression of radiographic osteoarthritis and self-reported outcomes: a cohort study.
Osteoarthritis and cartilage
Larsson S,Englund M,Struglics A,Lohmander LS
AHP0022 was used in ELISA to examine if changes in aggrecanase generated ARGS-aggrecan in synovial fluid is associated with progression of radiographic knee osteoarthritis and patient-reported outcome.
Tue May 01 00:00:00 UTC 2012
Cartilage and bone markers and inflammatory cytokines are increased in synovial fluid in the acute phase of knee injury (hemarthrosis)--a cross-sectional analysis.
Osteoarthritis and cartilage
Swärd P,Frobell R,Englund M,Roos H,Struglics A
AHP0022 was used in ELISA to determine the concentrations of cartilage and bone markers, and pro-inflammatory cytokines in synovial fluid collected from acutely injured knees with hemarthrosis and healthy controls.
Thu Nov 01 00:00:00 UTC 2012
Not all lubricin isoforms are substituted with a glycosaminoglycan chain.
Connective tissue research
Lord MS,Estrella RP,Chuang CY,Youssef P,Karlsson NG,Flannery CR,Whitelock JM
AHP0022 was used in ELISA to determine the structure and function of the glycosaminoglycan chain of lubricin in human synovial fluid.
Thu Jul 19 00:00:00 UTC 2012
Influence of different commercial scaffolds on the in vitro differentiation of human mesenchymal stem cells to nucleus pulposus-like cells.
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
Bertolo A,Mehr M,Aebli N,Baur M,Ferguson SJ,Stoyanov JV
Published figure using Aggrecan monoclonal antibody (Product # AHP0022) in Immunohistochemistry
Wed Aug 01 00:00:00 UTC 2012
Epiphyseal Chondroprogenitors Provide a Stable Cell Source for Cartilage Cell Therapy.
Cell medicine
Darwiche S,Scaletta C,Raffoul W,Pioletti DP,Applegate LA
Published figure using Aggrecan monoclonal antibody (Product # AHP0022) in Immunohistochemistry
Sun Jan 01 00:00:00 UTC 2012
Elevated aggrecanase activity in a rat model of joint injury is attenuated by an aggrecanase specific inhibitor.
Osteoarthritis and cartilage
Chockalingam PS,Sun W,Rivera-Bermudez MA,Zeng W,Dufield DR,Larsson S,Lohmander LS,Flannery CR,Glasson SS,Georgiadis KE,Morris EA
AHP0022 was used in ELISA to evaluate aggrecanase activity after traumatic knee injury in a rat model by measuring the level of aggrecanase-generated Ala-Arg-Gly-aggrecan (ARG-aggrecan) fragments in synovial fluid, and compare with ARG-aggrecan release into joint fluid following human knee injury.
Tue Mar 01 00:00:00 UTC 2011
A short-term pharmacodynamic model for monitoring aggrecanase activity: injection of monosodium iodoacetate (MIA) in rats and assessment of aggrecan neoepitope release in synovial fluid using novel ELISAs.
Osteoarthritis and cartilage
Swearingen CA,Chambers MG,Lin C,Marimuthu J,Rito CJ,Carter QL,Dotzlaf J,Liu C,Chandrasekhar S,Duffin KL,Mitchell PG,Durham TB,Wiley MR,Thirunavukkarasu K
AHP0022 was used in ELISA to develop an ELISA-based method to detect specific aggrecanase-cleaved aggrecan fragments in rats
Wed Sep 01 00:00:00 UTC 2010
Development of a novel clinical biomarker assay to detect and quantify aggrecanase-generated aggrecan fragments in human synovial fluid, serum and urine.
Osteoarthritis and cartilage
Swearingen CA,Carpenter JW,Siegel R,Brittain IJ,Dotzlaf J,Durham TB,Toth JL,Laska DA,Marimuthu J,Liu C,Brown DP,Carter QL,Wiley MR,Duffin KL,Mitchell PG,Thirunavukkarasu K
AHP0022 was used in ELISA to describe a method to detect aggrecanase-cleaved fragments of aggrecan in human serum and urine and use this assay to screen for inhibitors
Wed Sep 01 00:00:00 UTC 2010
Association between synovial fluid levels of aggrecan ARGS fragments and radiographic progression in knee osteoarthritis.
Arthritis research & therapy
Larsson S,Englund M,Struglics A,Lohmander LS
AHP0022 was used in western blot to study the association between synovial fluid levels of aggrecan ARGS fragments and radiographic progression in knee osteoarthritis.
Thu Jun 23 00:00:00 UTC 2011
Association between synovial fluid levels of aggrecan ARGS fragments and radiographic progression in knee osteoarthritis.
Arthritis research & therapy
Larsson S,Englund M,Struglics A,Lohmander LS
AHP0022 was used in western blot to study the association between synovial fluid levels of aggrecan ARGS fragments and radiographic progression in knee osteoarthritis.
Thu Jun 23 00:00:00 UTC 2011
Changes in serum and synovial fluid biomarkers after acute injury (NCT00332254).
Arthritis research & therapy
Catterall JB,Stabler TV,Flannery CR,Kraus VB
AHP0022 was used in ELISA to assess changes after acute injury to the anterior cruciate ligament using synovial fluid and serum biomarkers.
Thu Jun 23 00:00:00 UTC 2011
Comparative immunolocalisation of perlecan with collagen II and aggrecan in human foetal, newborn and adult ovine joint tissues demonstrates perlecan as an early developmental chondrogenic marker.
Histochemistry and cell biology
Smith SM,Shu C,Melrose J
AHP0022 was used in immunohistochemistry to determine the localization of type II collagen, aggrecan, and perlecan in young ovine joints
Wed Sep 01 00:00:00 UTC 2010
Silkworm and spider silk scaffolds for chondrocyte support.
Journal of materials science. Materials in medicine
Gellynck K,Verdonk PC,Van Nimmen E,Almqvist KF,Gheysens T,Schoukens G,Van Langenhove L,Kiekens P,Mertens J,Verbruggen G
AHP0022 was used in immunohistochemistry - frozen section to create scaffolds with silkworm cocoon, spider egg sac, and spider dragline silk fibers and examine their use for chondrocyte attachment and support
Sat Nov 01 00:00:00 UTC 2008
The use of Histochoice for histological examination of articular and growth plate cartilages, intervertebral disc and meniscus.
Biotechnic & histochemistry : official publication of the Biological Stain Commission
Melrose J,Smith SM,Smith MM,Little CB
AHP0022 was used in immunohistochemistry - paraffin section to compare Histochoice and formalin fixation for cartilaginous tissues
Fri Feb 01 00:00:00 UTC 2008
The structure, location, and function of perlecan, a prominent pericellular proteoglycan of fetal, postnatal, and mature hyaline cartilages.
The Journal of biological chemistry
Melrose J,Roughley P,Knox S,Smith S,Lord M,Whitelock J
AHP0022 was used in immunohistochemistry to study the localization and function of perlecan in human fetal, postnatal, and mature hyaline cartilages
Fri Dec 01 00:00:00 UTC 2006
Characterisation of human knee meniscus cell phenotype.
Osteoarthritis and cartilage
Verdonk PC,Forsyth RG,Wang J,Almqvist KF,Verdonk R,Veys EM,Verbruggen G
AHP0022 was used in flow cytometry to examine the extracellular matrix of human meniscus cells cultured under different conditions
Fri Jul 01 00:00:00 UTC 2005
Perlecan displays variable spatial and temporal immunolocalisation patterns in the articular and growth plate cartilages of the ovine stifle joint.
Histochemistry and cell biology
Melrose J,Smith S,Cake M,Read R,Whitelock J
AHP0022 was used in immunohistochemistry - paraffin section to study perlecan localization in the articular and epiphyseal growth plate cartilages of stifle joints in pedigree merino sheep
Wed Jun 01 00:00:00 UTC 2005
Culture of chondrocytes in alginate surrounded by fibrin gel: characteristics of the cells over a period of eight weeks.
Annals of the rheumatic diseases
Almqvist KF,Wang L,Wang J,Baeten D,Cornelissen M,Verdonk R,Veys EM,Verbruggen G
AHP0022 was used in immunocytochemistry to describe methods to generate cartilage from human articular chondrocytes.
Wed Aug 01 00:00:00 UTC 2001
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.jpg?time=20250104?time=20250104 "Aggrecan Antibody (AHP0022) in IHC (P)")
.jpg?time=20250104?time=20250104 "Aggrecan Antibody (AHP0022) in IHC (P)")
