Invitrogen

Aldolase A/B/C Monoclonal Antibody (E9)

View all (2) Aldolase A/B/C antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-47476

Applications
Tested Dilution
Publications

Western Blot (WB)

1:10,000
-

Immunohistochemistry (IHC)

1:1,000-1:5,000
-

Immunocytochemistry (ICC/IF)

1:1,000-1:5,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

E9

Immunogen

Recombinant human full-length aldolase C
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A/G

Storage buffer

PBS with 50% glycerol

Contains

5mM sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2942458

Target Information

Aldolases are important glycolytic cytosolic enzymes which catalyse the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate. There are three aldolase isozymes coded by three distinct genes in mammals, namely aldolases A, B, and C. Aldolase A is heavily expressed in muscle enzyme and aldolase B is heavily expressed in liver and is regarded as a liver specific enzyme. In the adult, aldolase C is the brain-specific isozyme expressed in astrocytes and a few classes of neurons, notably Purkinje cells. Appropriate antibodies to aldolase C are therefore useful to identify astrocytes in cell culture and sectioned material, and the enzyme may be over expressed in some forms of cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ALDA; ALDB; ALDC; Aldolase 1; aldolase 1, A isoform; Aldolase 2; aldolase 2, B isoform; Aldolase 3; aldolase A, fructose-bisphosphate; Aldolase B fructose-biphosphate; Aldolase B, fructose-biphosphate; aldolase B, fructose-bisphosphatase; aldolase B, fructose-bisphosphate; aldolase C, fructose-biphosphate; aldolase C, fructose-bisphosphate; Brain-type aldolase; epididymis secretory sperm binding protein Li 87p; fructoaldolase C; fructose-1,6-biphosphate triosephosphate lyase; fructose-1,6-bisphosphate triosephosphate-lyase; Fructose-bisphosphate aldolase A; Fructose-bisphosphate aldolase B; Fructose-bisphosphate aldolase C; Liver-type aldolase; Lung cancer antigen NY-LU-1; Muscle-type aldolase; Scrapie-responsive protein 2; Zebrin II

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Gene Aliases: AI847350; ALDA; ALDB; ALDC; ALDCAA; Aldo-1; Aldo-2; Aldo1; ALDO2; Aldo3; ALDOA; ALDOB; ALDOC; AU040929; BC016435; F16dip7; GSD12; HEL-S-87p; LIV10; RATALDCAA; RNALDOG5; Scrg2

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UniProt ID: (Human) P04075, (Human) P05062, (Human) P09972, (Mouse) P05064, (Rat) P05065, (Mouse) Q91Y97, (Mouse) P05063, (Rat) P09117

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Entrez Gene ID: (Human) 226, (Human) 229, (Human) 230, (Mouse) 11674, (Rat) 24189, (Mouse) 230163, (Rat) 24190, (Mouse) 11676, (Rat) 24191

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Function(s)
actin binding fructose-bisphosphate aldolase activity protein binding cytoskeletal protein binding tubulin binding identical protein binding poly(A) RNA binding fructose binding cadherin binding involved in cell-cell adhesion phosphatidylcholine binding ATPase binding fructose-1-phosphate aldolase activity protease binding molecular_function catalytic activity lyase activity
Process(es)
liver development fructose metabolic process gluconeogenesis glycolytic process NADH oxidation response to fructose response to zinc ion fructose 1,6-bisphosphate metabolic process cellular response to extracellular stimulus positive regulation of ATPase activity cellular response to insulin stimulus response to drug response to starvation response to amino acid response to copper ion response to glucocorticoid response to cAMP canonical glycolysis fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate vacuolar proton-transporting V-type ATPase complex assembly response to interleukin-6 epithelial cell differentiation response to peptide hormone ATP biosynthetic process striated muscle contraction regulation of cell shape muscle cell cellular homeostasis response to carbohydrate response to organic cyclic compound platelet degranulation actin filament organization protein homotetramerization cell-cell adhesion response to hypoxia response to heat response to lipopolysaccharide response to nicotine response to estrogen apoptotic process aging response to organonitrogen compound organ regeneration protein heterotetramerization
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