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Proteintech
Alpha-2-antiplasmin Polyclonal Antibody
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Product Details
28549-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Alpha-2-antiplasmin fusion protein Ag29670
Conjugate
Form
Liquid
Concentration
600 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
This gene encodes a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha 2 antiplasmin; Alpha-2-antiplasmin; Alpha-2-AP; Alpha-2-PI; Alpha-2-plasmin inhibitor; pigment epithelium derived factor; plasmin inhibitor alpha 2; serine (or cysteine) peptidase inhibitor, clade F, member 2; serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2; serine (or cysteine) proteinase inhibitor, clade F, member 2; Serpin F2; serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
Gene Aliases: A2AP; AAP; AI747498; ALPHA-2-PI; API; PLI; Serpimf2; SERPINF2
UniProt ID: (Human) P08697, (Mouse) Q61247
Entrez Gene ID: (Human) 5345, (Mouse) 18816, (Rat) 287527
regulation of blood vessel size by renin-angiotensin
acute-phase response
negative regulation of peptidase activity
negative regulation of plasminogen activation
negative regulation of endopeptidase activity
collagen fibril organization
positive regulation of collagen biosynthetic process
positive regulation of cell differentiation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JNK cascade
blood vessel morphogenesis
positive regulation of smooth muscle cell proliferation
positive regulation of stress fiber assembly
negative regulation of fibrinolysis
positive regulation of ERK1 and ERK2 cascade
positive regulation of transforming growth factor beta production
response to organic substance
platelet degranulation
fibrinolysis
positive regulation of cell-cell adhesion mediated by cadherin
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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