Invitrogen

Alpha-2a Adrenergic Receptor Recombinant Rabbit Monoclonal Antibody (3H29L10)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

703636

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

1:100
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

Expi293

Class

Recombinant Monoclonal

Type

Antibody

Clone

3H29L10

Immunogen

Peptides corresponding to human Alpha-2a Adrenergic Receptor [1) aa225-aa238 2) aa180-aa194]
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2762396

Product Specific Information

This antibody is predicted to react with Monkey, Cat, Pig, Mouse.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

Alpha-2-adrenergic receptors (ADRA2A) are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. ADRA2A mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G protein. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: adrenergic, alpha-2A-, receptor; Alpha-2 adrenergic receptor subtype C10; alpha-2-adrenergic receptor, platelet type; Alpha-2A adrenergic receptor; Alpha-2A adrenoceptor; Alpha-2A adrenoreceptor; alpha-2AAR subtype C10; OTTHUMP00000058849

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Gene Aliases: ADRA2; ADRA2A; ADRA2R; ADRAR; ALPHA2AAR; ZNF32

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UniProt ID: (Human) P08913

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Entrez Gene ID: (Human) 150

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Function(s)
alpha2-adrenergic receptor activity protein binding protein kinase binding alpha-1B adrenergic receptor binding alpha-2C adrenergic receptor binding thioesterase binding heterotrimeric G-protein binding protein homodimerization activity protein heterodimerization activity epinephrine binding norepinephrine binding
Process(es)
positive regulation of cytokine production acute inflammatory response DNA replication movement of cell or subcellular component signal transduction G-protein coupled receptor signaling pathway negative regulation of adenylate cyclase activity Ras protein signal transduction Rho protein signal transduction female pregnancy positive regulation of cell proliferation negative regulation of norepinephrine secretion regulation of vasoconstriction actin cytoskeleton organization platelet activation positive regulation of cell migration negative regulation of cAMP biosynthetic process activation of protein kinase activity activation of protein kinase B activity negative regulation of epinephrine secretion cellular response to hormone stimulus epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway glucose homeostasis positive regulation of potassium ion transport positive regulation of MAP kinase activity positive regulation of epidermal growth factor-activated receptor activity positive regulation of vasodilation negative regulation of calcium ion-dependent exocytosis negative regulation of insulin secretion regulation of insulin secretion intestinal absorption thermoception negative regulation of lipid catabolic process positive regulation of membrane protein ectodomain proteolysis negative regulation of calcium ion transport negative regulation of insulin secretion involved in cellular response to glucose stimulus negative regulation of uterine smooth muscle contraction negative regulation of adrenergic receptor signaling pathway adenylate cyclase-activating adrenergic receptor signaling pathway adenylate cyclase-inhibiting adrenergic receptor signaling pathway phospholipase C-activating adrenergic receptor signaling pathway activation of MAPK activity by adrenergic receptor signaling pathway positive regulation of wound healing negative regulation of calcium ion transmembrane transporter activity
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