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Proteintech
Alpha E catenin Monoclonal Antibody (2B7B8)
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Product Details
66221-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2B7B8
Immunogen
Alpha E catenin Fusion Protein Ag23603 (188-536 aa encoded by BC031262)
Conjugate
Form
Liquid
Concentration
2.08 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: SEMDNYEPG VYTEKVLEAT KLLSNTVMPR FTEQVEAAVE ALSSDPAQPM DENEFIDASR LVYDGIRDIR KAVLMIRTPE ELDDSDFETE DFDVRSRTSV QTEDDQLIAG QSARAIMAQL PQEQKAKIAE QVASFQEEKS KLDAEVSKWD DSGNDIIVLA KQMCMIMMEM TDFTRGKGPL KNTSDVISAA KKIAEAGSRM DKLGRTIADH CPDSACKQDL LAYLQRIALY CHQLNICSKV KAEVQNLGGE LVVSGVDSAM SLIQAAKNLM NAVVQTVKAS YVASTKYQKS QGMASLNLPA VSWKMKAPEK KPLVKREKQD ETQTKIKRAS QKKHVNPVQA LSEFKAMDSI (188-536 aa encoded by BC031262)
Target Information
Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherence junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 102 kDa cadherin-associated protein; alpha E catenin; Alpha E-catenin; alpha(E)-catenin; alpha-E-catenin; cadherin associated protein; Cadherin-associated protein; CAP102; catenin (cadherin-associated protein), alpha 1, 102kDa; catenin alpha 1; Catenin alpha-1; Renal carcinoma antigen NY-REN-13
Gene Aliases: 2010010M04Rik; AA517462; AI988031; CAP102; Catna1; CTNNA1; MDPT2
UniProt ID: (Human) P35221, (Mouse) P26231
Entrez Gene ID: (Human) 1495, (Mouse) 12385
ovarian follicle development
actin filament organization
cell adhesion
establishment or maintenance of cell polarity
negative regulation of neuroblast proliferation
aging
male gonad development
gap junction assembly
axon regeneration
adherens junction organization
cellular protein localization
odontogenesis of dentin-containing tooth
apical junction assembly
response to estrogen
positive regulation of smoothened signaling pathway
positive regulation of muscle cell differentiation
protein heterooligomerization
cellular response to indole-3-methanol
epithelial cell-cell adhesion
negative regulation of cell motility
negative regulation of integrin-mediated signaling pathway
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
regulation of cell proliferation
negative regulation of apoptotic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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