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Product Details
PA5-96273
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 60-290 of human alpha Sarcoglycan (alpha Sarcoglycan (SGCA)) (NP_0000141)
Conjugate
Form
Liquid
Concentration
1.58 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2808075
Product Specific Information
Immunogen sequence: ITYHAHLQGH PDLPRWLRYT QRSPHHPGFL YGSATPEDRG LQVIEVTAYN RDSFDTTRQR LVLEIGDPEG PLLPYQAEFL VRSHDAEEVL PSTPASRFLS ALGGLWEPGE LQLLNVTSAL DRGGRVPLPI EGRKEGVYIK VGSASPFSTC LKMVASPDSH ARCAQGQPPL LSCYDTLAPH FRVDWCNVTL VDKSVPEPAD EVPTPGDGIL EHDPFFCPPT EAPDRDFLVD A; Positive Samples: A-549, LO2, 293T, Mouse skeletal muscle, Mouse heart, Rat skeletal muscle, Rat heart; Cellular Location: Cell membrane, Cytoplasm, Single-pass type I membrane protein, cytoskeleton, sarcolemma
Target Information
The sarcoglycan transmembrane proteins are members of the dystrophin complex. Sarcoglycans cluster together to form a complex, which is localized in the cell membrane of skeletal, cardiac, and smooth muscle fibers. Four sarcoglycan subunit proteins, designated alpha-, beta-, gamma- and delta-sarcoglycan, form a complex on the skeletal muscle cell surface membrane. A genetic defect in any one of these proteins causes the loss or marked decrease of the whole sarcoglycan complex, which is observed in the autosomal recessive muscular dystrophy, sarcoglycanopathy. In smooth muscle, beta- and delta-sarcoglycans are associated with epsilon-sarcoglycan, a glycoprotein homologous to alpha-sarcoglycan. Additionally, a complete deficiency in delta-sarcoglycan is the cause of the Syrian hamster BIO.14 cardiomyopathy.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 50 kDa dystrophin-associated glycoprotein; 50DAG; 50kD DAG; Adhalin; Alpha-sarcoglycan; Alpha-SG; Dystroglycan 2; Dystroglycan-2; Dystroglycan2; limb girdle muscular dystrophy 2D; sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein); SG alpha; SG-alpha
Gene Aliases: 50DAG; adhalin; ADL; Asg; DAG2; DMDA2; LGMD2D; SCARMD1; SGCA
UniProt ID: (Human) Q16586, (Mouse) P82350
Entrez Gene ID: (Human) 6442, (Rat) 303468, (Mouse) 20391
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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