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Proteintech
Alpha adducin Polyclonal Antibody
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Product Details
10791-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Alpha adducin Fusion Protein Ag1245 (1-400 aa encoded by BC013393)
Conjugate
Form
Liquid
Concentration
0.37 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MNGDSRAAV VTSPPPTTAP HKERYFDRVD ENNPEYLRER NMAPDLRQDF NMMEQKKRVS MILQSPAFCE ELESMIQEQF KKGKNPTGLL ALQQIADFMT TNVPNVYPAA PQGGMAALNM SLGMVTPVND LRGSDSIAYD KGEKLLRCKL AAFYRLADLF GWSQLIYNHI TTRVNSEQEH FLIVPFGLLY SEVTASSLVK INLQGDIVDR GSTNLGVNQA GFTLHSAIYA ARPDVKCVVH IHTPAGAAVS AMKCGLLPIS PEALSLGEVA YHDYHGILVD EEEKVLIQKN LGPKSKVLIL RNHGLVSVGE SVEEAFYYIH NLVVACEIQV RTLASAGGPD NLVLLNPEKY KAKSRSPGSP VGEGTGSPPK WQIGEQEFEA LMRMLDNLGY RTSSSGRRQD G (1-400 aa encoded by BC013393)
Target Information
Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ADD2; ADDB; adducin 1 (alpha); Adducin beta; Adducin-1; Adducin-alpha; Adducin-beta; Adducin1; Alpha adducin; alpha-ADD; Alpha-adducin; beta Adducin; Beta-adducin; erythrocyte adducin alpha subunit; Erythrocyte adducin subunit alpha
Gene Aliases: ADD1; ADDA; AI256389
UniProt ID: (Human) P35611, (Mouse) Q9QYC0, (Rat) Q63028
Entrez Gene ID: (Human) 118, (Mouse) 11518, (Rat) 24170
actin binding
structural molecule activity
calmodulin binding
transcription factor binding
spectrin binding
protein homodimerization activity
poly(A) RNA binding
protein heterodimerization activity
actin filament binding
cadherin binding involved in cell-cell adhesion
T cell receptor binding
protein binding
cell morphogenesis
in utero embryonic development
cell volume homeostasis
hemoglobin metabolic process
erythrocyte differentiation
negative regulation of actin filament polymerization
positive regulation of protein binding
multicellular organism growth
positive regulation of angiogenesis
positive regulation of endocytosis
homeostasis of number of cells within a tissue
barbed-end actin filament capping
actin filament bundle assembly
cellular response to retinoic acid
actin cytoskeleton organization
IRE1-mediated unfolded protein response
transmembrane transport
cell-cell adhesion
ion transport
cytoskeleton organization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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