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Product Details
PA1-75475
Product Specifications
Species Reactivity
Chemical
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Amitriptyline-BTG
Conjugate
Form
Liquid
Purification
purified
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_1089626
Product Specific Information
Working Concentration: 2.5 µg/mL. Sensitivity: 10 ng/mL Amitriptyline produces 67% inhibition in a competitive ELISA employing Tricyclic Antidepressants (TCA) (1) polyclonal antibody.
Target Information
Amitriptyline is a Tricyclic Antidepressant that inhibits the re-uptake of norepinephrine and serotonin by the presynaptic neuronal membrane in the central nervous system (CNS), thereby increasing the synaptic concentration of norepinephrine and serotonin. Due to constant stimulation to these receptors, amitriptyline may produce a downregulation of adrenergic and serotonin receptors, which may contribute to the antidepressant activity. [National Center for Biotechnology Information. PubChem Compound Database; CID=2160].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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