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Invitrogen
Angiogenin Polyclonal Antibody
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Product Details
PA5-89249
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 25-147 of human ANG (NP_0011361)
Conjugate
Form
Liquid
Concentration
2.79 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2805443
Product Specific Information
Immunogen sequence: QDNSRYTHFL TQHYDAKPQG RDDRYCESIM RRRGLTSPCK DINTFIHGNK RSIKAICENK NGNPHRENLR ISKSSFQVTT CKLHGGSPWP PCQYRATAGF RNVVVACENG LPVHLDQSIF RRP; Positive Samples: LO2, HeLa, NCI-H460, B cells, Mouse liver, Rat liver; Cellular Location: Nucleus, basement membrane, extracellular matrix, extracellular space, nucleolus
Target Information
Angiogenin (ANG or ANG I) is important for the process of neovascularization and formation of new blood vessels. ANG is similar to pancreatic ribonuclease A and functions as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. It interacts with endothelial cell-surface actin and may cause changes in the cell cytoskeleton. ANG is thought to be involved in the development of solid tumors and its antagonists are capable of inhibiting tumor growth. Defects in ANG are the cause of susceptibility to amyotrophic lateral sclerosis type 9 (ALS9). Angiogenin is a genetic link between ALS and PD.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Angiogenin; angiogenin ribonuclease 1; angiogenin, ribonuclease A family, member 1; angiogenin, ribonuclease, RNase A family, 5; Angiogenin-1; epididymis luminal protein 168; MGC22466; MGC71966; Ribonuclease 5; ribonuclease A A1; ribonuclease A family member 5; RNase 5
Gene Aliases: AI385586; ALS9; ANG; Ang1; HEL168; RAA1; RNASE4; RNASE5; Rnase5a
UniProt ID: (Human) P03950, (Mouse) P21570
Entrez Gene ID: (Human) 283, (Mouse) 11727, (Rat) 305843
angiogenesis
response to hypoxia
positive regulation of endothelial cell proliferation
diacylglycerol biosynthetic process
activation of phospholipase C activity
multicellular organism development
central nervous system development
rRNA transcription
response to hormone
cell migration
negative regulation of translation
cell differentiation
activation of protein kinase B activity
activation of phospholipase A2 activity
positive regulation of phosphorylation
negative regulation of smooth muscle cell proliferation
positive regulation of protein secretion
nucleic acid phosphodiester bond hydrolysis
RNA phosphodiester bond hydrolysis
liver development
ovarian follicle development
oocyte maturation
response to yeast
placenta development
cell communication
antibacterial humoral response
antifungal humoral response
actin filament polymerization
adherens junction organization
homeostatic process
innate immune response
defense response to Gram-positive bacterium
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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