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Invitrogen
Angiogenin Recombinant Rabbit Monoclonal Antibody (HL2214)
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FIGURE: 1 / 3
Angiogenin Antibody (MA5-50435) in ICC/IF
Immunocytochemical analysis of Angiogenin using Angiogenin Recombinant Monoclonal Antibody (Product # MA5-50435) in HepG2 cells at a dilution of 1:500. Cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: Angiogenin stained by Angiogenin antibody (MA5-50435) diluted at 1:500. Blue: Fluoroshield with DAPI.
Product Details
MA5-50435
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
HL2214
Immunogen
Recombinant fragment of human Angiogenin.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_3093765
Target Information
Angiogenin (ANG or ANG I) is important for the process of neovascularization and formation of new blood vessels. ANG is similar to pancreatic ribonuclease A and functions as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. It interacts with endothelial cell-surface actin and may cause changes in the cell cytoskeleton. ANG is thought to be involved in the development of solid tumors and its antagonists are capable of inhibiting tumor growth. Defects in ANG are the cause of susceptibility to amyotrophic lateral sclerosis type 9 (ALS9). Angiogenin is a genetic link between ALS and PD.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Angiogenin; angiogenin, ribonuclease A family, member 1; angiogenin, ribonuclease, RNase A family, 5; Angiogenin-1; epididymis luminal protein 168; MGC22466; MGC71966; Ribonuclease 5; ribonuclease A A1; ribonuclease A family member 5; RNase 5
Gene Aliases: AI385586; ALS9; ANG; Ang1; HEL168; RAA1; RNASE4; RNASE5; Rnase5a
UniProt ID: (Human) P03950, (Mouse) P21570
Entrez Gene ID: (Human) 283, (Mouse) 11727
angiogenesis
response to hypoxia
positive regulation of endothelial cell proliferation
diacylglycerol biosynthetic process
activation of phospholipase C activity
multicellular organism development
central nervous system development
rRNA transcription
response to hormone
cell migration
negative regulation of translation
cell differentiation
activation of protein kinase B activity
activation of phospholipase A2 activity
positive regulation of phosphorylation
negative regulation of smooth muscle cell proliferation
positive regulation of protein secretion
nucleic acid phosphodiester bond hydrolysis
RNA phosphodiester bond hydrolysis
ovarian follicle development
oocyte maturation
response to yeast
placenta development
cell communication
antibacterial humoral response
antifungal humoral response
actin filament polymerization
adherens junction organization
homeostatic process
innate immune response
defense response to Gram-positive bacterium
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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