Invitrogen

Angiopoietin 1 Polyclonal Antibody

1 Published Figure
1 Reference
View all (28) Angiopoietin 1 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA1-32150

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:800
-

Immunocytochemistry (ICC/IF)

Assay-dependent
-

ELISA (ELISA)

1:5,000-1:25,000
-

Immunoprecipitation (IP)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse

Published species

Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to a N-terminus region near aa 15-45 of mouse angiopoietin 1 protein conjugated to KLH using maleimide.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

PBS, pH 7.2, with 0.15M NaCl

Contains

0.01% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2227195

Product Specific Information

This antibody is specific for mouse Angiopoietin 1 (mAng-1). Partial cross-reactivity is noted with human Angiopoietin 2. Store as a concentrated solution. Centrifuge briefly prior to opening vial.

Target Information

Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: ANG-1; Angiopoietin-1

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Gene Aliases: 1110046O21Rik; AGP1; AGPT; Ang-1; ANG1; ANGPT1; KIAA0003

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UniProt ID: (Human) Q15389, (Mouse) O08538

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Entrez Gene ID: (Human) 284, (Mouse) 11600

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Function(s)
Ras guanyl-nucleotide exchange factor activity receptor tyrosine kinase binding receptor binding vascular endothelial growth factor receptor binding
Process(es)
angiogenesis ovarian follicle development patterning of blood vessels vasculogenesis in utero embryonic development negative regulation of protein phosphorylation sprouting angiogenesis positive regulation of receptor internalization negative regulation of cytokine secretion involved in immune response endocardium morphogenesis negative regulation of cell adhesion transmembrane receptor protein tyrosine kinase signaling pathway activation of transmembrane receptor protein tyrosine kinase activity multicellular organism development endoderm development positive regulation of endothelial cell migration positive regulation of phosphatidylinositol 3-kinase signaling regulation of skeletal muscle satellite cell proliferation hemopoiesis cell differentiation heparin biosynthetic process positive regulation of vascular endothelial growth factor receptor signaling pathway positive regulation of protein ubiquitination cell-substrate adhesion regulation of tumor necrosis factor production positive regulation of peptidyl-serine phosphorylation protein localization to cell surface negative regulation of protein import into nucleus negative regulation of apoptotic process negative regulation of vascular permeability regulation of I-kappaB kinase/NF-kappaB signaling regulation of protein binding negative regulation of neuron apoptotic process positive regulation of blood vessel endothelial cell migration positive regulation of cell adhesion Tie signaling pathway positive regulation of peptidyl-tyrosine phosphorylation positive chemotaxis protein homooligomerization positive regulation of protein kinase B signaling cardiac muscle tissue morphogenesis vasculogenesis involved in coronary vascular morphogenesis positive regulation of ERK1 and ERK2 cascade glomerulus vasculature development negative regulation of endothelial cell apoptotic process regulation of macrophage migration inhibitory factor signaling pathway MAPK cascade regulation of endothelial cell proliferation positive regulation of GTPase activity leukocyte migration
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