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Invitrogen
Angiopoietin 2 Polyclonal Antibody
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FIGURE: 1 / 5
Angiopoietin 2 Antibody (PA5-118950) in IHC (P)
Immunohistochemistry analysis of Angiopoietin 2 in paraffin-embedded Human Placenta tissue. Samples were incubated with polyclonal antibody (Product # PA5-118950) at a dilution of 20 µg/mL, followed by HRP-Linked Caprine Anti-Rabbit IgG using a dilution of 2 µg/mL.
Product Details
PA5-118950
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein Angiopoietin 2. The antigen corresponds to amino acid range 24-165 of the target protein.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2903450
Target Information
ANG-2 binds to the endothelial cell specific receptor Tie-2, but, in contrast to ANG-1, does not induce tyrosine phosphorylation. Consequently, ANG-2 modulates ANG-1 activation of Tie-2 and, depending on the physiological and biochemical environment, can act either as an agonist or antagonist of Tie-2 induced angiogenesis. The signaling interactions of ANG-1, ANG-2 and Tie-2, along with less characterized ANG-3 and ANG-4, are required for embryonic and adult angiogenesis. Physiologically, ANG-1 and ANG-2 are associated with sprouting, tube formation, and structural integrity of newly formed blood vessels. Mature human ANG-2 is a secreted protein containing 480 amino acid residues. ANG-2 is composed of an alpha-helix-rich coiled coil N-terminal domain and fibrinogen-like C-terminal domain. ANG-2 exists predominantly in the form of a disulfide-linked dimer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ANG-2; Angiopoietin-2; angiopoietin-2a; angiopoietin-2B; Tie2-ligand
Gene Aliases: AGPT2; Ang-2; ANG2; ANGPT2
UniProt ID: (Human) O15123, (Mouse) O35608
Entrez Gene ID: (Human) 285, (Mouse) 11601
angiogenesis
blood vessel remodeling
transmembrane receptor protein tyrosine kinase signaling pathway
multicellular organism development
endoderm development
negative regulation of cell-substrate adhesion
negative regulation of angiogenesis
hemopoiesis
cell differentiation
negative regulation of blood vessel endothelial cell migration
regulation of angiogenesis
positive regulation of angiogenesis
Tie signaling pathway
blood vessel morphogenesis
negative regulation of positive chemotaxis
glomerulus vasculature development
response to hypoxia
signal transduction
germ cell development
response to radiation
response to mechanical stimulus
response to glucose
response to organic cyclic compound
response to activity
organ regeneration
leukocyte migration
maternal process involved in female pregnancy
cellular response to growth factor stimulus
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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