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Invitrogen
Angiopoietin 2 Recombinant Rabbit Monoclonal Antibody (JM71-34)
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Product Details
MA5-32759
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
JM71-34
Immunogen
Synthetic peptide within Human Angiopoietin 2 aa 351-400
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2810036
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
ANG-2 binds to the endothelial cell specific receptor Tie-2, but, in contrast to ANG-1, does not induce tyrosine phosphorylation. Consequently, ANG-2 modulates ANG-1 activation of Tie-2 and, depending on the physiological and biochemical environment, can act either as an agonist or antagonist of Tie-2 induced angiogenesis. The signaling interactions of ANG-1, ANG-2 and Tie-2, along with less characterized ANG-3 and ANG-4, are required for embryonic and adult angiogenesis. Physiologically, ANG-1 and ANG-2 are associated with sprouting, tube formation, and structural integrity of newly formed blood vessels. Mature human ANG-2 is a secreted protein containing 480 amino acid residues. ANG-2 is composed of an alpha-helix-rich coiled coil N-terminal domain and fibrinogen-like C-terminal domain. ANG-2 exists predominantly in the form of a disulfide-linked dimer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ANG-2; Angiopoietin-2; angiopoietin-2a; angiopoietin-2B; Tie2-ligand
Gene Aliases: AGPT2; Ang-2; ANG2; ANGPT2
UniProt ID: (Human) O15123, (Mouse) O35608, (Rat) O35462
Entrez Gene ID: (Human) 285, (Mouse) 11601, (Rat) 89805
angiogenesis
blood vessel remodeling
transmembrane receptor protein tyrosine kinase signaling pathway
multicellular organism development
endoderm development
negative regulation of cell-substrate adhesion
negative regulation of angiogenesis
hemopoiesis
cell differentiation
negative regulation of blood vessel endothelial cell migration
regulation of angiogenesis
positive regulation of angiogenesis
Tie signaling pathway
blood vessel morphogenesis
negative regulation of positive chemotaxis
glomerulus vasculature development
response to hypoxia
signal transduction
germ cell development
response to radiation
response to mechanical stimulus
response to glucose
response to organic cyclic compound
response to activity
organ regeneration
leukocyte migration
maternal process involved in female pregnancy
cellular response to growth factor stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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