Alomone Labs, LTD

Angiotensin II Receptor Type-1 (extracellular) Polyclonal Antibody

View all (18) AGTR1 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

AAR-011-200UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500
-

Immunohistochemistry (IHC)

Assay-dependent
-

Immunocytochemistry (ICC/IF)

1:100
-

Flow Cytometry (Flow)

2.5 µg
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

NSSTEDGIKRIQDDC, corresponding to amino acid residues 4-18 of human AT1 receptor, Extracellular, N-terminus
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.7 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).

Target Information

AGTR1 is known as Angiotensin II Type 1 Receptor. Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. And it acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. Moreover, this gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: angiotensin II receptor, type 1; Angiotensin II type-1 receptor; Angiotensin II type-1 receptor A; angiotensin II type-1A receptor; angiotensin receptor 1; angiotensin receptor 1a; AT1 receptor; AT1 receptor A; AT1AR; AT1BR; Type-1 angiotensin II receptor; Type-1 angiotensin II receptor A; type-1A angiotensin II receptor; type-1B angiotensin II receptor; vascular type-1 angiotensin II receptor

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Gene Aliases: 1810074K20Rik; AG2S; Agtr-1a; AGTR1; AGTR1A; AGTR1B; AI551199; Angtr-1a; AT1; AT1A; AT1AR; AT1B; AT1BR; AT1R; AT2R1; AT2R1A; AT2R1B; HAT1R

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UniProt ID: (Human) P30556, (Rat) P25095, (Mouse) P29754

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Entrez Gene ID: (Human) 185, (Rat) 24180, (Mouse) 11607

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Function(s)
angiotensin type I receptor activity angiotensin type II receptor activity protein binding bradykinin receptor binding protein heterodimerization activity G-protein alpha-subunit binding peptide hormone binding protein kinase binding D1 dopamine receptor binding protein self-association signal transducer activity G-protein coupled receptor activity
Process(es)
blood vessel development kidney development positive regulation of receptor recycling regulation of systemic arterial blood pressure by circulatory renin-angiotensin renin secretion into blood stream renin-angiotensin regulation of aldosterone production regulation of renal output by angiotensin brain renin-angiotensin system regulation of pH inflammatory response G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration Rho protein signal transduction heart development aging regulation of blood pressure positive regulation of cell proliferation positive regulation of cholesterol esterification regulation of vasoconstriction calcium-mediated signaling positive regulation of cellular protein metabolic process positive regulation of phospholipase A2 activity positive regulation of superoxide anion generation regulation of smooth muscle cell apoptotic process negative regulation of smooth muscle cell apoptotic process angiotensin-activated signaling pathway vasoconstriction dopamine biosynthetic process drinking behavior activation of Janus kinase activity negative regulation of neuron apoptotic process response to estrogen positive regulation of blood pressure positive regulation of cytokine secretion positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway cell chemotaxis cellular response to dexamethasone stimulus phospholipase C-activating angiotensin-activated signaling pathway positive regulation of branching involved in ureteric bud morphogenesis regulation of cell growth regulation of blood vessel size by renin-angiotensin regulation of systemic arterial blood pressure by renin-angiotensin positive regulation of macrophage derived foam cell differentiation positive regulation of NAD(P)H oxidase activity low-density lipoprotein particle remodeling regulation of renal sodium excretion regulation of cell proliferation regulation of vasodilation regulation of inflammatory response positive regulation of inflammatory response positive regulation of reactive oxygen species metabolic process signal transduction
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