Alomone Labs, LTD

Angiotensin II Receptor Type-2 (extracellular) Polyclonal Antibody

View all (9) AGTR2 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

AAR-012-200UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:400
-

Immunohistochemistry (IHC)

Assay-dependent
-

Immunocytochemistry (ICC/IF)

1:100
-

Flow Cytometry (Flow)

2.5 µg
-
Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

DNLNATGTNESAFNC, corresponding to amino acid residues 21-35 of rat AT2 receptor, Extracellular, N-terminal domain
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.8 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).

Target Information

Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion that acts through at least two types of receptors, AGTR1 and AGTR2. It is an important effector controlling blood pressure and volume in the cardiovascular system and plays a major role in the development of the mammalian kidney and urinary tract. Like AGTR1, AGTR2 is a seven transmembrane G protein-coupled receptor (GPCR), but AGTR2 does not demonstrate most of the classic features of GPCR signaling. AGTR2 is involved in a wide range of activities, including the induction of neurite outgrowth and the inhibition of cellular proliferation, in addition to the known function of mediation of vasoconstriction.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Angiotensin ii at2; angiotensin II type 2 receptor; Angiotensin II type-2 receptor; angiotensin receptor 2; AT2; AT2 receptor; Type-2 angiotensin II receptor

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Gene Aliases: Agtr2; AI316812; AT2-R; AT2R; AT2R; AW107640

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UniProt ID: (Rat) P35351, (Mouse) P35374

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Entrez Gene ID: (Rat) 24182, (Mouse) 11609

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Function(s)
G-protein alpha-subunit binding angiotensin type II receptor activity protein binding transcription factor binding peptide hormone binding signal transducer activity G-protein coupled receptor activity
Process(es)
kidney development regulation of systemic arterial blood pressure by circulatory renin-angiotensin renin-angiotensin regulation of aldosterone production vasodilation by angiotensin involved in regulation of systemic arterial blood pressure brain renin-angiotensin system cellular sodium ion homeostasis inflammatory response cell surface receptor signaling pathway G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger positive regulation of cell proliferation response to organonitrogen compound negative regulation of heart rate negative regulation of norepinephrine secretion cerebellar cortex development neuron differentiation negative regulation of icosanoid secretion positive regulation of phosphoprotein phosphatase activity intracellular signal transduction regulation of metanephros size exploration behavior positive regulation of renal sodium excretion aldosterone secretion angiotensin-activated signaling pathway dopamine biosynthetic process regulation of transcription factor import into nucleus negative regulation of neuron apoptotic process positive regulation of transcription, DNA-templated positive regulation of vasodilation negative regulation of fibroblast proliferation positive regulation of cytokine secretion positive regulation of nitric-oxide synthase activity negative regulation of neurotrophin TRK receptor signaling pathway kidney morphogenesis cell growth involved in cardiac muscle cell development cellular response to dexamethasone stimulus positive regulation of metanephric glomerulus development positive regulation of branching involved in ureteric bud morphogenesis positive regulation of extrinsic apoptotic signaling pathway signal transduction G-protein coupled receptor signaling pathway regulation of vasodilation regulation of apoptotic process
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