Invitrogen

Ankyrin B Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-82326

Applications
Tested Dilution
Publications

Western Blot (WB)

0.04-0.4 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500
-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human ANK2. Recombinant protein control fragment (Product #RP-102423).
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.10 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2789485

Product Specific Information

Immunogen sequence: ERLAYIADHL GFSWTELARE LDFTEEQIHQ IRIENPNSLQ DQSHALLKYW LERDGKHATD TNLVECLTKI NRMDIVHLME TNTEPLQERI SHSYAEIEQT ITLDHSEGFS VLQEELCTAQ HKQKEEQAVS KESETC

Target Information

This gene encodes a member of the ankyrin family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton. Ankyrins play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. The protein encoded by this gene is required for targeting and stability of Na/Ca exchanger 1 in cardiomyocytes. Mutations in this gene cause long QT syndrome 4. Multiple transcript variants encoding different isoforms have been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ANK-2; ankyrin B; ankyrin, brain; Ankyrin-2; ankyrin-2, nonerythrocytic; Ankyrin-B; Brain ankyrin; Non-erythroid ankyrin

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Gene Aliases: ANK-2; ANK2; ANKB; brank-2; LQT4

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UniProt ID: (Human) Q01484

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Entrez Gene ID: (Human) 287

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Function(s)
structural constituent of cytoskeleton protein binding cytoskeletal adaptor activity enzyme binding protein kinase binding spectrin binding protein binding, bridging ion channel binding ATPase binding
Process(es)
regulation of heart rate atrial septum development cellular calcium ion homeostasis ER to Golgi vesicle-mediated transport cytoskeleton organization positive regulation of gene expression regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion regulation of cardiac muscle contraction by calcium ion signaling paranodal junction assembly regulation of protein stability T-tubule organization protein localization to organelle protein localization to cell surface cellular protein localization protein localization to M-band protein localization to T-tubule positive regulation of potassium ion transport protein stabilization regulation of release of sequestered calcium ion into cytosol response to methylmercury regulation of calcium ion transport positive regulation of calcium ion transport regulation of cardiac muscle contraction regulation of ventricular cardiac muscle cell membrane repolarization sarcoplasmic reticulum calcium ion transport protein localization to endoplasmic reticulum protein localization to plasma membrane protein targeting to plasma membrane regulation of cardiac muscle cell contraction ventricular cardiac muscle cell action potential atrial cardiac muscle cell action potential SA node cell action potential membrane depolarization during SA node cell action potential atrial cardiac muscle cell to AV node cell communication SA node cell to atrial cardiac muscle cell communication regulation of heart rate by cardiac conduction regulation of SA node cell action potential regulation of atrial cardiac muscle cell action potential positive regulation of potassium ion transmembrane transporter activity regulation of calcium ion transmembrane transporter activity positive regulation of calcium ion transmembrane transporter activity positive regulation of cation channel activity
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