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Invitrogen
Annexin A2 Polyclonal Antibody
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Product Details
PA1-86306
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide sequence STVHEILCKLSLEGD corresponding to the N-terminal region of Annexin II (NP_001002858.1; NP_004030.1; NP_001002857.1)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_927011
Product Specific Information
Predicted to react with bovine, mouse, pig and rat based on sequence homology.
In Western blot, this antibody detects a band at ~35 kDa in A431 and A549 cell lysates.
Goat anti Human Annexin II (N-Terminal) antibody recognizes an epitope within the N terminal (NT) region of Annexin II, a member of a family of structurally related calcium binding proteins implicated in mediating the the intracellular action of calcium.
Target Information
This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Annexin A2; Annexin II; Annexin-2; Calpactin I heavy chain; calpactin I heavy polypeptide; Calpactin-1 heavy chain; chromobindin 8; Chromobindin-8; epididymis secretory protein Li 270; Lipocortin II; p36; PAP-IV; Placental anticoagulant protein IV; Protein I
Gene Aliases: ANX2; ANX2L4; ANXA2; CAL1H; HEL-S-270; LIP2; LPC2; LPC2D; P36; PAP-IV
UniProt ID: (Human) P07355
Entrez Gene ID: (Human) 302
protease binding
calcium ion binding
protein binding
calcium-dependent phospholipid binding
phosphatidylinositol-4,5-bisphosphate binding
cytoskeletal protein binding
Rab GTPase binding
phospholipase A2 inhibitor activity
receptor activator activity
S100 protein binding
poly(A) RNA binding
calcium-dependent protein binding
cadherin binding involved in cell-cell adhesion
angiogenesis
membrane raft assembly
positive regulation of protein phosphorylation
negative regulation of receptor internalization
membrane budding
body fluid secretion
collagen fibril organization
positive regulation of vesicle fusion
negative regulation of low-density lipoprotein particle receptor catabolic process
osteoclast development
fibrinolysis
negative regulation of catalytic activity
positive regulation of fibroblast proliferation
positive regulation of binding
protein heterotetramerization
protein targeting to plasma membrane
response to thyroid hormone
cell-cell adhesion
negative regulation of receptor binding
positive regulation of receptor activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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