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Product Details
A81-112P
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Human Apolipoprotein CI.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.01% thimerosal
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Apolipoproteins are protein components of plasma lipoproteins. The apolipoprotein C gene family encodes four homologous proteins designated apoC-I to -IV, which specifically modulate the metabolism of triglyceride-rich lipoproteins. The human apoC-I gene maps to chromosome 19q13.2 and is expressed primarily in the liver where it is activated when monocytes differentiate into macrophages. The human apoC-II gene maps to chromosome 19q13.2 and encodes a 79 amino acid single chain protein that is a necessary cofactor for the activation of lipoprotein lipase, the enzyme that hydrolyzes triglycerides in plasma and transfers the fatty acids to tissues. The human apoC-III gene maps to chromosome 11q23 and encodes a protein that may delay catabolism of triglyceride-rich particles by inhibiting lipoprotein lipase and hepatic lipase. The human apoC-IV gene maps to chromosome 19q13.2 and encodes a 127 amino acid protein that is primarily expressed in the liver.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Apo-CI; Apolipoprotein C-I; apolipoprotein C-I variant I; apolipoprotein C-I variant II; Apolipoprotein C1
Gene Aliases: Apo-CI; apo-CIB; ApoC-I; apoC-IB; APOC1
UniProt ID: (Human) P02654
Entrez Gene ID: (Human) 341
lipid metabolic process
triglyceride metabolic process
cholesterol metabolic process
positive regulation of cholesterol esterification
negative regulation of phosphatidylcholine catabolic process
negative regulation of very-low-density lipoprotein particle clearance
regulation of cholesterol transport
negative regulation of cholesterol transport
cholesterol efflux
phospholipid efflux
plasma lipoprotein particle remodeling
high-density lipoprotein particle remodeling
very-low-density lipoprotein particle assembly
chylomicron remnant clearance
very-low-density lipoprotein particle clearance
lipoprotein metabolic process
positive regulation of catalytic activity
negative regulation of fatty acid biosynthetic process
negative regulation of lipid metabolic process
negative regulation of receptor-mediated endocytosis
negative regulation of lipid catabolic process
negative regulation of lipoprotein lipase activity
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