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Invitrogen
Aprutumab Recombinant Human Monoclonal Antibody
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FIGURE: 1 / 1
Aprutumab Antibody (MA5-42124) in SDS-PAGE
SDS-PAGE analysis of the recombinant Human FGFR2 protein expressed in CHO cells using a Aprutumab biosimilar monoclonal antibody (Product # MA5-42124). R denotes the lane was run under reducing conditions. NR denotes the lane was run under non-reducing conditions.
Product Details
MA5-42124
Product Specifications
Species Reactivity
Human
Host/Isotype
Human
/ IgG1, lambda
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Immunogen
Human FGFR2
Conjugate
Form
Liquid
Concentration
2.9 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.5
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2911267
Product Specific Information
Endotoxin level < 0.01EU/µg by LAL method
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 °C for one week. Store at -20 to -80 °C for twelve months from the date of receipt.
Target Information
Aprutumab is a biosimilar that targets FGFR2. FGFR2 is a member of the fibroblast growth factor receptor family. It is a tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays a central role in the regulation of cell proliferation, differentiation, migration, apoptosis, and embryonic development. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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