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Invitrogen
Aquaporin 12 Polyclonal Antibody
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Product Details
PA5-59918
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human Aquaporin 12. Recombinant protein control fragment (Product #RP-104335).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2638102
Product Specific Information
Immunogen sequence: FQRNLFYGQK NKYRAPRGKP APASGDTQTP AKGSSVREPG RSGVE
Highest antigen sequence identity to the following orthologs: Mouse - 42%, Rat - 40%.
Target Information
Aquaporin 12 (AQP12) is the most recently identified member of the mammalian AQP family and is specifically expressed in pancreatic acinar cells. In vitro expression studies have revealed that AQP12 is localized at intracellular sites. To determine the physiological roles of AQP12 in the pancreas, we generated knockout mice for this gene (AQP12-KO). No obvious differences were observed under normal conditions between wild-type (WT) and AQP12-KO mice in terms of growth, blood chemistry, pancreatic fluid content, or histology. However, when we induced pancreatitis through the administration of a cholecystokinin-8 (CCK-8) analog, the AQP12-KO mice showed more severe pathological damage to this organ than WT mice.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AQP-12; AQP-12B; aquaporin 12; aquaporin X2; insulin synthesis associated 3; Putative aquaporin-12A; Putative aquaporin-12B
Gene Aliases: AQP-12; AQP12; AQP12A; AQP12B; AQPX2; INSSA3
UniProt ID: (Human) Q8IXF9, (Human) A6NM10
Entrez Gene ID: (Human) 375318, (Human) 653437
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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