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Invitrogen
Aquaporin 4 Recombinant Rabbit Monoclonal Antibody (5A4W4)
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FIGURE: 1 / 5
Aquaporin 4 Antibody (MA5-35079) in IHC (P)
Confocal imaging (Immunohistochemistry) of Aquaporin 4 in human brain. Samples were incubated with Aquaporin 4 Monoclonal antibody (Product # MA5-35079) using a dilution of 1:100 (Red). DAPI was used for nuclear staining (blue). Objective: 40x. Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IF staining protocol.
Product Details
MA5-35079
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
5A4W4
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 256-323 of human Aquaporin-4 (AQP4) (NP_0016411)
Conjugate
Form
Liquid
Concentration
0.9 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2848984
Product Specific Information
Immunogen sequence: VEFKRRFKEA FSKAAQQTKG SYMEVEDNRS QVETDDLILK PGVVHVIDVD RGEEKKGKDQ SGEVLSSV
Target Information
In skeletal muscle, AQP4 (aquaporin 4 also known as mercurial insensitive water channel), localizes to the sarcolemma of fast-twitch muscle fibers. Aquaporins (AQPs) are a large family of integral membrane water transport channel proteins that facilitate the transport of water through the cell membrane. This function is conserved in animals, plants and bacteria. Many isoforms of aquaporin have been identified in mammals, designated AQP0 through AQP10. Aquaporins are widely distributed and it is not uncommon for more than one type of AQP to be present in the same cell. Although most aquaporins are only permeable to water, AQP3, AQP7, AQP9 and one of the two AQP10 transcripts are also permeable to urea and glycerol.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AQP-4; aquaporin type4; Aquaporin-4; Aquaporin4; HMIWC2; Mercurial-insensitive water channel; MGC22454; MIWC; WCH4
Gene Aliases: AQP-4; AQP4; MIWC; MIWC2; WCH4
UniProt ID: (Human) P55087, (Mouse) P55088, (Rat) P47863
Entrez Gene ID: (Human) 361, (Mouse) 11829, (Rat) 25293
renal water homeostasis
transport
water transport
cellular water homeostasis
glycerol transport
ion transmembrane transport
multicellular organismal water homeostasis
cellular response to interferon-gamma
sensory perception of sound
regulation of vascular endothelial growth factor production
carbon dioxide transport
water homeostasis
negative regulation of interleukin-1 beta production
negative regulation of interleukin-6 production
carbohydrate transmembrane transport
protein homooligomerization
transmembrane transport
negative regulation of cell adhesion molecule production
renal water absorption
cellular response to glucose stimulus
female pregnancy
response to radiation
hyperosmotic salinity response
response to glucocorticoid
cellular response to interleukin-1
cellular response to interleukin-6
cellular response to estradiol stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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