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Invitrogen
Atpalpha Polyclonal Antibody
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Product Details
PA5-32094
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Fruit fly,
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the C-terminus region of Drosophila Atpalpha. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2549567
Product Specific Information
Recommended positive controls: Drosophila lysate.
Predicted reactivity: Drosophila (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The ATPa, or ATPalpha gene, encodes a subunit of the Na+/K+ ATPase enzyme, which is crucial for maintaining cellular ion gradients by actively transporting Na+ out of cells and K+ into cells. This gene is essential in various organisms, including Drosophila melanogaster (fruit fly). Mutations in the ATPalpha gene can lead to significant developmental and physiological abnormalities, such as neurodegeneration, altered longevity, and myodegeneration. One of its critical roles is in neuromuscular functioning, where it affects locomotor activity, with mutations causing conditional bang-sensitive or temperature-sensitive paralysis. Additionally, ATPalpha mutations disrupt the formation and function of septate junctions in Drosophila, structures analogous to vertebrate tight junctions, further underscoring its role in maintaining cellular integrity and signal transduction.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: (Na[+] + K[+])-ATPase alpha-subunit; (Na[+],K[+])ATPase alpha subunit; alpha-subunit of ATPase; ATPalpha; Atpalpha-PA; Atpalpha-PB; Atpalpha-PC; Atpalpha-PD; Atpalpha-PE; Atpalpha-PF; Atpalpha-PG; Atpalpha-PH; Atpalpha-PI; Atpalpha-PJ; Atpalpha-PK; ATPase alpha; ATPase alpha subunit; CG5670-PA; CG5670-PB; CG5670-PC; CG5670-PD; CG5670-PE; CG5670-PF; CG5670-PG; CG5670-PH; CG5670-PI; CG5670-PJ; CG5670-PK; Na pump alpha subunit; Na(+)/K(+) ATPase alpha subunit; Na+,K+ ATPase alpha-subunit; Na, K ATPase a subunit; Na,K ATPase; Na,K ATPase alpha subunit; Na,K-ATPase; Na,K-ATPase alpha; Na,K-ATPase alpha subunit; Na,K-ATPase alpha-subunit; Na[ +], K[ +] -ATPase; Na[+] pump alpha subunit; Na[+], K[+] ATPase alpha; Na[+],K[+] ATPase alpha subunit; Na[+],K[+]-ATPase alpha subunit; Na[+]-K[+] ATPase; Na[+]/K[+] ATPase (alpha subunit); Na[+]/K[+] ATPase alpha subunit; Na[+]K[+] ATPase alpha subunit; Na[+]K[+]ATPase; sodium pump alpha subunit; sodium pump alpha-subunit; Sodium pump subunit alpha; Sodium/potassium-transporting ATPase subunit alpha
Gene Aliases: (Na[+]/k[+])-ATPase; Atp a; ATP-alpha; ATPa; ATPalpha; ATPBagr; CG5670; Da-47; Dmel\CG5670; Dmel_CG5670; dnATPase; JY; K ATPase; K-ATPase; K[+] -ATPase; K[+]-ATPase; K[+]-ATPase alpha subunit; K[+]-ATPase alpha-subunit; l(3)01164; l(3)01453; l(3)04492; l(3)j3B2; l(3)j3B7; l(3)j6A4; l(3)rM454; l(3)ry136; Na; Na+-K+-ATPase; Na+/K+ ATPase alpha subunit; Na-p; Na/K ATPase; Na/K-ATPase; Na/K-ATPase alpha-subunit; Na[+]; Na[+]-K[+]-ATPase alpha[[5]]-subunit; Na[+]/K[+] ATPase; Na[+]/K[+]-ATPase; Na[+]/K[+]ATPase; Na[+]K[+] ATPase; Na[+]K[+]-ATPase; Na[+]K[+]ATPase; NaK; NaK ATPase; sodium/potassium transporting ATPase alpha
UniProt ID: (Fruit fly) P13607
Entrez Gene ID: (Fruit fly) 48971
embryonic development via the syncytial blastoderm
tissue homeostasis
cation transport
potassium ion transport
sodium ion transport
chemical synaptic transmission
sensory perception of sound
locomotory behavior
jump response
determination of adult lifespan
adult locomotory behavior
regulation of cell shape
response to temperature stimulus
response to mechanical stimulus
septate junction assembly
regulation of tube architecture, open tracheal system
regulation of tube diameter, open tracheal system
regulation of tube length, open tracheal system
neuromuscular process
synaptic growth at neuromuscular junction
trachea morphogenesis
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