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Fabgennix
Aurora A Polyclonal Antibody, Biotin
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Product Details
AURKA-BIOTIN
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within amino acid region 350-397 on human Aurora Kinase A protein.
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
AURKA (Aurora A) is a serine/threonine kinase that regulates mitosis by association in vivo with centrosomes. Overexpression of AURKA is observed in many types of cancer. Aurora A plays a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. Aurora A plays a key role during tumor development and progression and is overexpressed in many human cancers including breast, ovarian and colorectal. Aurora A is viewed as a potential target for anticancer drug treatment. Tissue specificity: Highly expressed in testis and weakly in skeletal muscle, thymus and spleen.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ARK-1; AURAK; Aurora 2; aurora A; Aurora A Kinase; aurora family kinase 1; Aurora kinase A; aurora-A; aurora-related kinase 1; aurora/IP; Aurora/IPL1-related kinase 1; AURORA2; EC 2.7.11.1; hARK1; Ipl1- and aurora-related kinase 1; IPL1-related kinase; MGC34538; OTTHUMP00000031341; OTTHUMP00000166072; ratAurA; RP5-1167H4.6; serine/threonine kinase 6; serine/threonine protein kinase 6; Serine/threonine-protein kinase 15; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase aurora-A; Serine/threonine-protein kinase Ayk1
Gene Aliases: Aik; AIRK1; ARK-1; Ark1; AU019385; Aura; Aurka; Aurora-A; AW539821; Ayk1; Btak; IAK; IAK1; Stk15; Stk6
UniProt ID: (Mouse) P97477
Entrez Gene ID: (Mouse) 20878, (Rat) 261730
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
protein serine/threonine/tyrosine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
protein kinase binding
ubiquitin protein ligase binding
histone serine kinase activity
meiotic spindle organization
microtubule cytoskeleton organization
mitotic cell cycle
protein phosphorylation
cell cycle
spindle organization
mitotic spindle organization
spindle assembly involved in female meiosis I
mitotic nuclear division
mitotic centrosome separation
meiotic nuclear division
anterior/posterior axis specification
phosphorylation
cell projection organization
regulation of protein stability
negative regulation of protein binding
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of cytokinesis
histone-serine phosphorylation
negative regulation of apoptotic process
centrosome organization
cell division
centrosome localization
protein localization to centrosome
negative regulation of spindle checkpoint
positive regulation of oocyte maturation
neuron projection extension
response to estradiol
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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