Invitrogen

Aurora A/B Monoclonal Antibody (5A12)

View all (2) Aurora A/B antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-47439

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:2,000
-

Immunohistochemistry (IHC)

1:1,000-1:2,000
-

Immunocytochemistry (ICC/IF)

1:1,000-1:2,000
-
Product Specifications

Species Reactivity

Dog, Horse, Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

5A12

Immunogen

Full length recombinant human Aurora A protein expressed in and purified from E. coli.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A/G

Storage buffer

PBS with 50% glycerol

Contains

5mM sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2942421

Target Information

The Aurora gene, a serine-threonine kinase, orginally discovered in Drosophila, has been found to be responsible for a chromosomal segregation defect. The mammalian homologues of Drosophila Aurora have been termed ARK1 (Aurora-related kinase 1) and ARK2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: AIM-1; ARK-1; ARK-2; Aurora 1; Aurora 2; aurora A; aurora B; aurora family kinase 1; Aurora kinase A; Aurora kinase B; aurora kinase B-Sv1; aurora kinase B-Sv2; Aurora- and IPL1-like midbody-associated protein 1; aurora-1; aurora-A; aurora-B; aurora-related kinase 1; aurora-related kinase 2; aurora/IPL1-like kinase; Aurora/IPL1-related kinase 1; Aurora/IPL1-related kinase 2; Breast tumor-amplified kinase; Ipl1- and aurora-related kinase 1; protein phosphatase 1, regulatory subunit 47; protein phosphatase 1, regulatory subunit 48; ratAurA; serine/threonine kinase 12; serine/threonine kinase 5; serine/threonine kinase 6; serine/threonine protein kinase 15; serine/threonine protein kinase 6; Serine/threonine-protein kinase 12; Serine/threonine-protein kinase 15; Serine/threonine-protein kinase 5; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase aurora-A; Serine/threonine-protein kinase aurora-B; Serine/threonine-protein kinase Ayk1; STK-1

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Gene Aliases: AIK; AIK2; AIM-1; AIM1; AIRK1; AIRK2; AL022959; ARK-1; ARK-2; ARK1; ARK2; AU019385; AURA; AurB; AURKA; AURKB; aurkb-sv1; aurkb-sv2; Aurora-A; AW539821; AYK1; BTAK; IAK; IAK1; IPL1; PPP1R47; PPP1R48; STK-1; STK1; STK12; STK15; STK5; STK6; STK7

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UniProt ID: (Human) O14965, (Human) Q96GD4, (Mouse) P97477, (Mouse) O70126, (Rat) O55099

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Entrez Gene ID: (Dog) 485940, (Human) 6790, (Human) 9212, (Dog) 479492, (Mouse) 20878, (Rat) 261730, (Mouse) 20877, (Rat) 114592

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Function(s)
protein kinase activity protein serine/threonine kinase activity protein serine/threonine/tyrosine kinase activity protein binding ATP binding protein kinase binding ubiquitin protein ligase binding histone serine kinase activity metal ion binding nucleotide binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups
Process(es)
negative regulation of transcription from RNA polymerase II promoter negative regulation of B cell apoptotic process protein phosphorylation spindle organization sister chromatid cohesion aging cell proliferation attachment of spindle microtubules to kinetochore abscission histone modification protein sumoylation anaphase-promoting complex-dependent catabolic process spindle checkpoint negative regulation of protein binding positive regulation of telomere maintenance via telomerase negative regulation of cytokinesis positive regulation of cytokinesis protein localization to kinetochore cellular response to UV cleavage furrow formation protein ubiquitination involved in ubiquitin-dependent protein catabolic process histone H3-S28 phosphorylation protein autophosphorylation mitotic spindle midzone assembly positive regulation of telomerase activity regulation of chromosome segregation regulation of signal transduction by p53 class mediator positive regulation of telomere capping meiotic spindle organization microtubule cytoskeleton organization mitotic cell cycle cell cycle mitotic spindle organization spindle assembly involved in female meiosis I mitotic nuclear division mitotic centrosome separation meiotic nuclear division anterior/posterior axis specification phosphorylation cell projection organization regulation of protein stability positive regulation of proteasomal ubiquitin-dependent protein catabolic process regulation of cytokinesis histone-serine phosphorylation negative regulation of apoptotic process centrosome organization cell division centrosome localization protein localization to centrosome negative regulation of spindle checkpoint positive regulation of oocyte maturation neuron projection extension response to estradiol G2/M transition of mitotic cell cycle DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest positive regulation of mitotic nuclear division regulation of centrosome cycle
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