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Invitrogen
BABAM1 Monoclonal Antibody (GT1251)
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FIGURE: 1 / 2
BABAM1 Antibody (MA5-27830) in ICC/IF
C19orf62 antibody [GT1251] detects C19orf62 protein at cytoplasm and nucleus by immunofluorescent analysis. Sample: HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: C19orf62 protein stained by C19orf62 antibody [GT1251] (Product # MA5-27830) diluted at 1:500. Blue: Hoechst 33342 staining.
Product Details
MA5-27830
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
GT1251
Immunogen
Recombinant protein encompassing a sequence within the N-terminus region of human HSPC142. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2735224
Product Specific Information
Positive Control: 293T, A431, HeLa, HepG2
Predicted Reactivity: Rhesus Monkey (97%), Bovine (87%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
HSPC142 is a component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. HSPC142 probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BRCA1-A complex subunit MERIT40; BRISC and BRCA1-A complex member 1; mediator of Rap80 interactions and targeting 40 kDa; Mediator of RAP80 interactions and targeting subunit of 40 kDa; new component of the BRCA1 A complex; New component of the BRCA1-A complex; new component of the BRCAA1 A complex
Gene Aliases: BABAM1; C19orf62; HSPC142; MERIT40; NBA1
UniProt ID: (Human) Q9NWV8
Entrez Gene ID: (Human) 29086
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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