Proteintech

BACH1 Polyclonal Antibody

BACH1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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BACH1 Antibody (14018-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human breast hyperplasia tissue slide using 14018-1-AP ( BACH1 antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

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Product Details

14018-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 20 publications 20 publications

Immunohistochemistry (IHC)

View 9 publications 9 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 6 publications 6 publications

ChIP assay (ChIP)

View 2 publications 2 publications

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

BACH1 Fusion Protein Ag5128 (387-736 aa encoded by BC063307)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.45 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: SSVEREVAE HLAKGFWSDI CSTDTPCQMQ LSPAVAKDGS EQISQKRSEC PWLGIRISES PEPGQRTFTT LSSVNCPFIS TLSTEGCSSN LEIGNDDYVS EPQQEPCPYA CVISLGDDSE TDTEGDSESC SAREQECEVK LPFNAQRIIS LSRNDFQSLL KMHKLTPEQL DCIHDIRRRS KNRIAAQRCR KRKLDCIQNL ESEIEKLQSE KESLLKERDH ILSTLGETKQ NLTGLCQKVC KEAALSQEQI QILAKYSAAD CPLSFLISEK DKSTPDGELA LPSIFSLSDR PPAVLPPCAR GNSEPGYARG QESQQMSTAT SEQAGPAEQC RQSGGISDFC QQMTDKCTTD E (387-736 aa encoded by BC063307)

Target Information

BACH1.3 is a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo and/or hetero oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene. Some exons of this gene overlap with some exons from the C21orf41 gene, which is transcribed in an opposite orientation to this gene, but which does not seem to encode a protein.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

BACH1 deficiency prevents neointima formation and maintains the differentiated phenotype of vascular smooth muscle cells by regulating chromatin accessibility.

Nucleic acids research

Guo J,Qiu J,Jia M,Li Q,Wei X,Li L,Pan Q,Jin J,Ge F,Ma S,He Y,Lin J,Li Y,Ma J,Jiang N,Zhi X,Jiang L,Zhang J,Osto E,Jing Q,Wang X,Meng D

Mon May 22 00:00:00 UTC 2023

Regulation of DNA damage response by trimeric G-proteins.

iScience

Abd El-Hafeez AA,Sun N,Chakraborty A,Ear J,Roy S,Chamarthi P,Rajapakse N,Das S,Luker KE,Hazra TK,Luker GD,Ghosh P

Fri Feb 17 00:00:00 UTC 2023

Bach1 modulates AKT3 transcription to participate in hyperglycaemia-mediated EndMT in vascular endothelial cells.

Clinical and experimental pharmacology & physiology

Meng Z,Shen W,Yu L,Tong F,He H,Hu Y,Wu W,Liu J

Thu Jun 01 00:00:00 UTC 2023

Bach1 modulates AKT3 transcription to participate in hyperglycaemia-mediated EndMT in vascular endothelial cells.

Clinical and experimental pharmacology & physiology

Meng Z,Shen W,Yu L,Tong F,He H,Hu Y,Wu W,Liu J

Thu Jun 01 00:00:00 UTC 2023

Bach1 modulates AKT3 transcription to participate in hyperglycaemia-mediated EndMT in vascular endothelial cells.

Clinical and experimental pharmacology & physiology

Meng Z,Shen W,Yu L,Tong F,He H,Hu Y,Wu W,Liu J

Thu Jun 01 00:00:00 UTC 2023

BACH1 promotes intervertebral disc degeneration by regulating HMOX1/GPX4 to mediate oxidative stress, ferroptosis, and lipid metabolism in nucleus pulposus cells.

The journal of gene medicine

Yao B,Cai Y,Wan L,Deng J,Zhao L,Wang W,Han Z

Thu Jun 01 00:00:00 UTC 2023

BACH1 promotes intervertebral disc degeneration by regulating HMOX1/GPX4 to mediate oxidative stress, ferroptosis, and lipid metabolism in nucleus pulposus cells.

The journal of gene medicine

Yao B,Cai Y,Wan L,Deng J,Zhao L,Wang W,Han Z

Thu Jun 01 00:00:00 UTC 2023

BACH1 regulates the proliferation and odontoblastic differentiation of human dental pulp stem cells.

BMC oral health

Liu C,Yu J,Liu B,Liu M,Song G,Zhu L,Peng B

Thu Nov 24 00:00:00 UTC 2022

BACH1 regulates the proliferation and odontoblastic differentiation of human dental pulp stem cells.

BMC oral health

Liu C,Yu J,Liu B,Liu M,Song G,Zhu L,Peng B

Thu Nov 24 00:00:00 UTC 2022

BACH1 regulates the proliferation and odontoblastic differentiation of human dental pulp stem cells.

BMC oral health

Liu C,Yu J,Liu B,Liu M,Song G,Zhu L,Peng B

Thu Nov 24 00:00:00 UTC 2022

Glucose Increases Hepatic Mitochondrial Antioxidant Enzyme Activities in Insulin Resistant Rats Following Chronic Angiotensin Receptor Blockade.

International journal of molecular sciences

Godoy-Lugo JA,Thorwald MA,Mendez DA,Rodriguez R,Nakano D,Nishiyama A,Ortiz RM

Sat Sep 17 00:00:00 UTC 2022

The MBNL1/circNTRK2/PAX5 pathway regulates aerobic glycolysis in glioblastoma cells by encoding a novel protein NTRK2-243aa.

Cell death & disease

Zhao Y,Song J,Dong W,Liu X,Yang C,Wang D,Xue Y,Ruan X,Liu L,Wang P,Zhang M,Liu Y

Mon Sep 05 00:00:00 UTC 2022

G-quadruplexes sense natural porphyrin metabolites for regulation of gene transcription and chromatin landscapes.

Genome biology

Li C,Yin Z,Xiao R,Huang B,Cui Y,Wang H,Xiang Y,Wang L,Lei L,Ye J,Li T,Zhong Y,Guo F,Xia Y,Fang P,Liang K

Thu Dec 15 00:00:00 UTC 2022

The SETD8/ELK1/bach1 complex regulates hyperglycaemia-mediated EndMT in diabetic nephropathy.

Journal of translational medicine

Li X,Lu L,Hou W,Wang F,Huang T,Meng Z,Zhu M

Tue Mar 29 00:00:00 UTC 2022

Protective effect of tin chloride on rhabdomyolysis-induced acute kidney injury in rats.

PloS one

Ohtani S,Shimizu H,Yamaoka M,Takahashi T,Omori E,Morimatsu H

Wed May 04 00:00:00 UTC 2022

MEF2D-NR4A1-FAM134B2-mediated reticulophagy contributes to amino acid homeostasis.

Autophagy

Shiozaki Y,Miyazaki-Anzai S,Keenan AL,Miyazaki M

Sun May 01 00:00:00 UTC 2022

Interplay of Nrf2 and BACH1 in inducing ferroportin expression and enhancing resistance of human macrophages towards ferroptosis.

Cell death discovery

Namgaladze D,Fuhrmann DC,Brüne B

Tue Jul 19 00:00:00 UTC 2022

Defective BACH1/HO-1 regulatory circuits in cystic fibrosis bronchial epithelial cells.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

Chillappagari S,Garapati V,Mahavadi P,Naehrlich L,Schmeck BT,Schmitz ML,Guenther A

Fri Jan 01 00:00:00 UTC 2021

PTEN deficiency facilitates the therapeutic vulnerability to proteasome inhibitor bortezomib in gallbladder cancer.

Cancer letters

Jiang TY,Feng XF,Fang Z,Cui XW,Lin YK,Pan YF,Yang C,Ding ZW,Zhang YJ,Tan YX,Wang HY,Dong LW

Wed Mar 31 00:00:00 UTC 2021

PTEN deficiency facilitates the therapeutic vulnerability to proteasome inhibitor bortezomib in gallbladder cancer.

Cancer letters

Jiang TY,Feng XF,Fang Z,Cui XW,Lin YK,Pan YF,Yang C,Ding ZW,Zhang YJ,Tan YX,Wang HY,Dong LW

Wed Mar 31 00:00:00 UTC 2021

PTEN deficiency facilitates the therapeutic vulnerability to proteasome inhibitor bortezomib in gallbladder cancer.

Cancer letters

Jiang TY,Feng XF,Fang Z,Cui XW,Lin YK,Pan YF,Yang C,Ding ZW,Zhang YJ,Tan YX,Wang HY,Dong LW

Wed Mar 31 00:00:00 UTC 2021

MicroRNA-30c-5p protects against myocardial ischemia/reperfusion injury via regulation of Bach1/Nrf2.

Toxicology and applied pharmacology

Sun M,Guo M,Ma G,Zhang N,Pan F,Fan X,Wang R

Wed Sep 01 00:00:00 UTC 2021

Single-Cell Analysis Identify Transcription Factor BACH1 as a Master Regulator Gene in Vascular Cells During Aging.

Frontiers in cell and developmental biology

Ge F,Pan Q,Qin Y,Jia M,Ruan C,Wei X,Jing Q,Zhi X,Wang X,Jiang L,Osto E,Guo J,Meng D

Tue Jan 11 00:00:00 UTC 2022

Heme oxygenase-1 induction by heat shock in rat hepatoma cell line is regulated by the coordinated function of HSF1, NRF2 and BACH1.

Journal of biochemistry

Akagi R,Kubo T,Hatori Y,Miyamoto T,Inouye S

Sat Dec 04 00:00:00 UTC 2021

Role of the Transcription Factor BTB and CNC Homology 1 in a Rat Model of Acute Liver Injury Induced by Experimental Endotoxemia.

Acta medica Okayama

Tanioka N,Shimizu H,Omori E,Takahashi T,Yamaoka M,Morimatsu H

Tue Jun 01 00:00:00 UTC 2021

Enterovirus 71 induces neural cell apoptosis and autophagy through promoting ACOX1 downregulation and ROS generation.

Virulence

You L,Chen J,Liu W,Xiang Q,Luo Z,Wang W,Xu W,Wu K,Zhang Q,Liu Y,Wu J

Tue Dec 01 00:00:00 UTC 2020

PTEN status determines chemosensitivity to proteasome inhibition in cholangiocarcinoma.

Science translational medicine

Jiang TY,Pan YF,Wan ZH,Lin YK,Zhu B,Yuan ZG,Ma YH,Shi YY,Zeng TM,Dong LW,Tan YX,Wang HY

Wed Sep 23 00:00:00 UTC 2020

PTEN status determines chemosensitivity to proteasome inhibition in cholangiocarcinoma.

Science translational medicine

Jiang TY,Pan YF,Wan ZH,Lin YK,Zhu B,Yuan ZG,Ma YH,Shi YY,Zeng TM,Dong LW,Tan YX,Wang HY

Wed Sep 23 00:00:00 UTC 2020

PTEN status determines chemosensitivity to proteasome inhibition in cholangiocarcinoma.

Science translational medicine

Jiang TY,Pan YF,Wan ZH,Lin YK,Zhu B,Yuan ZG,Ma YH,Shi YY,Zeng TM,Dong LW,Tan YX,Wang HY

Wed Sep 23 00:00:00 UTC 2020

S-1-Propenylcysteine augments BACH1 degradation and heme oxygenase 1 expression in a nitric oxide-dependent manner in endothelial cells.

Nitric oxide : biology and chemistry

Tsuneyoshi T,Kunimura K,Morihara N

Fri Mar 01 00:00:00 UTC 2019

S-1-Propenylcysteine augments BACH1 degradation and heme oxygenase 1 expression in a nitric oxide-dependent manner in endothelial cells.

Nitric oxide : biology and chemistry

Tsuneyoshi T,Kunimura K,Morihara N

Fri Mar 01 00:00:00 UTC 2019

Astragaloside IV Regulates the PI3K/Akt/HO-1 Signaling Pathway and Inhibits H9c2 Cardiomyocyte Injury Induced by Hypoxia-Reoxygenation.

Biological & pharmaceutical bulletin

Yang P,Zhou Y,Xia Q,Yao L,Chang X

Wed May 01 00:00:00 UTC 2019

microRNA 155 up regulation in the CNS is strongly correlated to Down's syndrome dementia.

Annals of diagnostic pathology

Tili E,Mezache L,Michaille JJ,Amann V,Williams J,Vandiver P,Quinonez M,Fadda P,Mikhail A,Nuovo G

Fri Jun 01 00:00:00 UTC 2018

The electrophilic character of quinones is essential for the suppression of Bach1.

Toxicology

Su C,Liu Z,Wang Y,Wang Y,Song E,Song Y

Sat Jul 15 00:00:00 UTC 2017

The electrophilic character of quinones is essential for the suppression of Bach1.

Toxicology

Su C,Liu Z,Wang Y,Wang Y,Song E,Song Y

Sat Jul 15 00:00:00 UTC 2017

The electrophilic character of quinones is essential for the suppression of Bach1.

Toxicology

Su C,Liu Z,Wang Y,Wang Y,Song E,Song Y

Sat Jul 15 00:00:00 UTC 2017

The electrophilic character of quinones is essential for the suppression of Bach1.

Toxicology

Su C,Liu Z,Wang Y,Wang Y,Song E,Song Y

Sat Jul 15 00:00:00 UTC 2017

Dynamic changes in Bach1 expression in the kidney of rhabdomyolysis-associated acute kidney injury.

PloS one

Yamaoka M,Shimizu H,Takahashi T,Omori E,Morimatsu H

Fri Sep 22 00:00:00 UTC 2017

Dynamic changes in Bach1 expression in the kidney of rhabdomyolysis-associated acute kidney injury.

PloS one

Yamaoka M,Shimizu H,Takahashi T,Omori E,Morimatsu H

Fri Sep 22 00:00:00 UTC 2017

Tetrachlorobenzoquinone induces Nrf2 activation via rapid Bach1 nuclear export/ubiquitination and JNK-P62 signaling.

Toxicology

Su C,Shi Q,Song X,Fu J,Liu Z,Wang Y,Wang Y,Xia X,Song E,Song Y

Fri Jul 01 00:00:00 UTC 2016

Tetrachlorobenzoquinone induces Nrf2 activation via rapid Bach1 nuclear export/ubiquitination and JNK-P62 signaling.

Toxicology

Su C,Shi Q,Song X,Fu J,Liu Z,Wang Y,Wang Y,Xia X,Song E,Song Y

Fri Jul 01 00:00:00 UTC 2016

Tetrachlorobenzoquinone induces Nrf2 activation via rapid Bach1 nuclear export/ubiquitination and JNK-P62 signaling.

Toxicology

Su C,Shi Q,Song X,Fu J,Liu Z,Wang Y,Wang Y,Xia X,Song E,Song Y

Fri Jul 01 00:00:00 UTC 2016

Tetrachlorobenzoquinone induces Nrf2 activation via rapid Bach1 nuclear export/ubiquitination and JNK-P62 signaling.

Toxicology

Su C,Shi Q,Song X,Fu J,Liu Z,Wang Y,Wang Y,Xia X,Song E,Song Y

Fri Jul 01 00:00:00 UTC 2016

Zinc Protoporphyrin Upregulates Heme Oxygenase-1 in PC-3 Cells via the Stress Response Pathway.

International journal of cell biology

Kwok SC

Tue Mar 12 00:00:00 UTC 2013

Zinc Protoporphyrin Upregulates Heme Oxygenase-1 in PC-3 Cells via the Stress Response Pathway.

International journal of cell biology

Kwok SC

Tue Mar 12 00:00:00 UTC 2013

Bioinformatics

Protein Aliases: basic region leucine zipper transcriptional regulator BACH1; BTB and CNC homolog 1; BTB and CNC homology 1 transcription factor; BTB and CNC homology 1, basic leucine zipper transcription factor 1; HA2303; Transcription regulator protein BACH1

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Gene Aliases: 6230421P05Rik; AI323795; BACH-1; BACH1; BTBD24

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UniProt ID: (Human) O14867, (Mouse) P97302

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Entrez Gene ID: (Human) 571, (Mouse) 12013, (Rat) 304127

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Function(s)

RNA polymerase II distal enhancer sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding transcription factor activity, sequence-specific DNA binding ubiquitin-protein transferase activity protein binding heme binding DNA binding sequence-specific DNA binding

Process(es)

regulation of transcription involved in G1/S transition of mitotic cell cycle regulation of transcription involved in G2/M transition of mitotic cell cycle negative regulation of transcription from RNA polymerase II promoter DNA repair transcription, DNA-templated regulation of transcription, DNA-templated transcription from RNA polymerase II promoter positive regulation of transcription from RNA polymerase II promoter regulation of transcription from RNA polymerase II promoter in response to hypoxia protein ubiquitination

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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BACH1 Polyclonal Antibody

BACH1 Antibody (14018-1-AP) in IHC (P)

Product Details

14018-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

ChIP assay (ChIP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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