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Invitrogen
BAF53B Polyclonal Antibody
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Product Details
PA5-117088
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human ACTL6B (NP_0572721)
Conjugate
Form
Liquid
Concentration
0.53 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2901718
Product Specific Information
Positive Samples: HL-60, 22Rv1, BT-474, HeLa, HepG2, Mouse brain, Mouse skeletal muscle
Immunogen sequence: MSGGVYGGDE VGALVFDIGS FSVRAGYAGE DCPKADFPTT VGLLAAEEGG GLELEGDKEK KGKIFHIDTN ALHVPRDGAE VMSPLKNGMI EDWECFRAIL DHTYSKHVKS EPNLHPVLMS EAPWNTRAKR EKLTELMFEQ YNIPAFFLCK TAVLTAFANG RSTGLVLDSG ATHTTAIPVH DGYVLQQGIV KSPLAGDFIS MQCRELFQEM AIDIIPPYMI AAKEPVREGA PPNWKKKEKL PQVSKSWHNY MCNEVIQDFQ ASVLQVSDSP YDEQVAAQMP
Target Information
Belongs to the chromatin remodeling brain-specific BAF (bBAF) complex, as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex) and is required for postmitotic neural development and dendritic outgrowth. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. ACTL6B/BAF53B is not essential for assembly of the nBAF complex but is required for targeting the complex and CREST to the promoter of genes essential for dendritic growth.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 53 kDa BRG1-associated factor B; actin-like 6; Actin-like protein 6B; actin-like protein 6B {ECO:0000250|UniProtKB:O94805}; Actin-related protein Baf53b; actl6b {ECO:0000250|UniProtKB:O94805}; ArpN-alpha; ArpNa; ArpNalpha; BAF53B; BRG1-associated factor 53B; hArpN alpha
Gene Aliases: ACTL6; ACTL6B; ArpNa; arpNalpha; BAF53B
UniProt ID: (Human) O94805, (Rat) P86173, (Mouse) Q99MR0
Entrez Gene ID: (Human) 51412, (Rat) 288563, (Mouse) 83766
chromatin organization
chromatin remodeling
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
cytoskeleton organization
covalent chromatin modification
spinal cord development
regulation of transcription, DNA-templated
nervous system development
chromatin assembly or disassembly
chromatin modification
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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