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Invitrogen
BAG6 Recombinant Rabbit Monoclonal Antibody (8P4D9)
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FIGURE: 1 / 1
BAG6 Antibody (MA5-42688) in WB
Western blot analysis of BAG6 in extracts of various cell lines. Samples were incubated with BAG6 Monoclonal antibody (Product # MA5-42688) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Product Details
MA5-42688
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
8P4D9
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1033-1132 of human BAT3/BAG6 (P46379).
Conjugate
Form
Liquid
Concentration
0.49 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2911829
Product Specific Information
Positive test controls include: 293T, NIH/3T3, C6, Mouse testis. The target is usually found in the following locations: Cytoplasm, Nucleus, cytosol.
Immunogen sequence: KPQPPLSDAY LSGMPAKRRK TMQGEGPQLL LSEAVSRAAK AAGARPLTSP ESLSRDLEAP EVQESYRQQL RSDIQKRLQE DPNYSPQRFP NAQRAFADDP
Target Information
This gene was first characterized as part of a cluster of genes located within the human major histocompatibility complex class III region. This gene encodes a nuclear protein that is cleaved by caspase 3 and is implicated in the control of apoptosis. In addition, the protein forms a complex with E1A binding protein p300 and is required for the acetylation of p53 in response to DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BAG 6; BAG family molecular chaperone regulator 6; BAG-6; BAT 3; BCL2-associated athanogene 6; DAQB-195H10.3; HLA-B associated transcript 3; HLA-B associated transcript-3; HLA-B-associated transcript 3; Large proline-rich protein BAG6; large proline-rich protein BAT3; Protein G3; Protein Scythe; scythe
Gene Aliases: 2410045D21Rik; AA408914; BAG-6; BAG6; BAT3; D17H6S52E; D6S52E; G3; Scythe
UniProt ID: (Human) P46379, (Rat) Q6MG49, (Mouse) Q9Z1R2
Entrez Gene ID: (Human) 7917, (Rat) 94342, (Mouse) 224727
kidney development
immune system process
ubiquitin-dependent protein catabolic process
transport
synaptonemal complex assembly
spermatogenesis
brain development
chromatin modification
internal peptidyl-lysine acetylation
cell differentiation
lung development
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of cell proliferation
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of proteolysis
protein stabilization
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
tail-anchored membrane protein insertion into ER membrane
embryo development
covalent chromatin modification
positive regulation of ERAD pathway
maintenance of unfolded protein involved in ERAD pathway
protein localization to cytosolic proteasome complex involved in ERAD pathway
antigen processing and presentation of peptide antigen via MHC class I
apoptotic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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