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Product Details
PA5-99051
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Brain-specific angiogenesis inhibitor 1-associated protein 2 protein (123-368AA)
Conjugate
Form
Liquid
Concentration
4 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2813664
Target Information
The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BAI-associated protein 2; BAI1-associated protein 2; BAR/IMD domain-containing adapter protein 2; Brain-specific angiogenesis inhibitor 1-associated protein 2; Fas ligand-associated factor 3; FLAF3; insulin receptor substrate of 53 kDa; insulin receptor substrate p53; Insulin receptor substrate p53/p58; Insulin receptor substrate protein of 53 kDa; Insulin receptor tyrosine kinase 53 kDa substrate; IRS-58; IRSp53; IRSp53/58
Gene Aliases: BAIAP2; BAP2; FLAF3; IRSP53; R75030
UniProt ID: (Human) Q9UQB8, (Mouse) Q8BKX1
Entrez Gene ID: (Human) 10458, (Mouse) 108100
plasma membrane organization
Rho protein signal transduction
insulin receptor signaling pathway
regulation of cell shape
response to bacterium
dendrite development
positive regulation of actin filament polymerization
regulation of actin cytoskeleton organization
regulation of synaptic plasticity
actin filament bundle assembly
actin crosslink formation
positive regulation of dendritic spine morphogenesis
positive regulation of actin cytoskeleton reorganization
axonogenesis
Fc-gamma receptor signaling pathway involved in phagocytosis
vascular endothelial growth factor receptor signaling pathway
cell-cell adhesion
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