Proteintech

BAP31 Polyclonal Antibody

BAP31 Antibody in Immunocytochemistry (ICC/IF)

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BAP31 Antibody (11200-1-AP) in ICC/IF

Immunofluorescent analysis of (4% PFA) fixed HeLa cells using BAP31 antibody (Product # 11200-1-AP) at dilution of 1:0 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L), phalloidin stains F-actin (red).

BAP31 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

BAP31 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

11200-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 14 publications 14 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

View 4 publications 4 publications

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

BAP31 Fusion Protein Ag1668 (1-246 aa encoded by BC014323)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.24 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSLQWTAVA TFLYAEVFVV LLLCIPFISP KRWQKIFKSR LVELLVSYGN TFFVVLIVIL VLLVIDAVRE IREYDDVTEK VNLQNNPGAM EHFHMKLFRA QRNLYIAGFS LLLSFLLRRL VTLISQQATL LASNEAFKKQ AESASEAAKK YMEENDQLKK GAAVDGGKLD VGNAEVKLEE ENRSLKADLQ KLKDELASTK QKLEKAENQV LAMRKQSEGL TKEYDRLLEE HAKLQAAVDG PMDKKEE (1-246 aa encoded by BC014323)

Target Information

BAP31 (B-Cell Receptor Associated Protein, 31-kDa) is a multiple membrane spanning protein of the endoplasmic reticulum. It has been shown to form both homo- and hetero-oligomers with the closely related BAP29, and is a potential apoptotic regulator as a predicted BCL-2/BCL-XL-associated protein. In the C-terminal domain of BAP31, there are two identical recognition sites for initiator Caspases 1 and 8 of the programmed death cascade. It is hypothesized that BAP31 plays a role in the transport of selected proteins to the Golgi apparatus. BAP31 has also been shown to control expression of CFTR (cystic fibrosis transmembrane conductance regulator). It is believed that interference with the expression or function of BAP31 in epithelial cells may be a way to circumvent the chloride channel defect in cystic fibrosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Rapid nuclear deadenylation of mammalian messenger RNA.

iScience

Alles J,Legnini I,Pacelli M,Rajewsky N

Fri Jan 20 00:00:00 UTC 2023

BAP31 regulates the expression of ICAM-1/VCAM-1 via MyD88/NF-κB pathway in acute lung injury mice model.

Life sciences

Li G,Jiang X,Liang X,Hou Y,Zang J,Zhu B,Jia C,Niu K,Liu X,Xu X,Jiang R,Wang B

Sun Jan 15 00:00:00 UTC 2023

Caffeic acid phenethyl ester protects against doxorubicin-induced cardiotoxicity and increases chemotherapeutic efficacy by regulating the unfolded protein response.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Zhang Y,Kong D,Han H,Cao Y,Zhu H,Cui G

Sat Jan 01 00:00:00 UTC 2022

Calcineurin Controls Cellular Prion Protein Expression in Mouse Astrocytes.

Cells

Dematteis G,Restelli E,Vanella VV,Manfredi M,Marengo E,Corazzari M,Genazzani AA,Chiesa R,Lim D,Tapella L

Thu Feb 10 00:00:00 UTC 2022

B-cell receptor associated protein 31 deficiency decreases the expression of adhesion molecule CD11b/CD18 and PSGL-1 in neutrophils to ameliorate acute lung injury.

The international journal of biochemistry & cell biology

Li GX,Jiang XH,Zang JN,Zhu BZ,Jia CC,Niu KW,Liu X,Jiang R,Wang B

Tue Nov 01 00:00:00 UTC 2022

Co-translational biogenesis of lipid droplet integral membrane proteins.

Journal of cell science

Leznicki P,Schneider HO,Harvey JV,Shi WQ,High S

Tue Mar 01 00:00:00 UTC 2022

Mammalian oocytes store mRNAs in a mitochondria-associated membraneless compartment.

Science (New York, N.Y.)

Cheng S,Altmeppen G,So C,Welp LM,Penir S,Ruhwedel T,Menelaou K,Harasimov K,Stützer A,Blayney M,Elder K,Möbius W,Urlaub H,Schuh M

Fri Oct 21 00:00:00 UTC 2022

HDLBP binds ER-targeted mRNAs by multivalent interactions to promote protein synthesis of transmembrane and secreted proteins.

Nature communications

Zinnall U,Milek M,Minia I,Vieira-Vieira CH,Müller S,Mastrobuoni G,Hazapis OG,Del Giudice S,Schwefel D,Bley N,Voigt F,Chao JA,Kempa S,Hüttelmaier S,Selbach M,Landthaler M

Wed May 18 00:00:00 UTC 2022

Proteomic analyses reveal that Orf virus induces the activation and maturation of mouse bone marrow-derived dendritic cells.

Research in veterinary science

Feng Q,Li L,Du G,Liu Y,Liu X,Wu J,Shang Y

Thu Oct 01 00:00:00 UTC 2020

Down-regulation of the islet-specific zinc transporter-8 (ZnT8) protects human insulinoma cells against inflammatory stress.

The Journal of biological chemistry

Merriman C,Fu D

Fri Nov 08 00:00:00 UTC 2019

Down-regulation of the islet-specific zinc transporter-8 (ZnT8) protects human insulinoma cells against inflammatory stress.

The Journal of biological chemistry

Merriman C,Fu D

Fri Nov 08 00:00:00 UTC 2019

MiR-451a suppressing BAP31 can inhibit proliferation and increase apoptosis through inducing ER stress in colorectal cancer.

Cell death & disease

Xu K,Han B,Bai Y,Ma XY,Ji ZN,Xiong Y,Miao SK,Zhang YY,Zhou LM

Fri Feb 15 00:00:00 UTC 2019

MiR-451a suppressing BAP31 can inhibit proliferation and increase apoptosis through inducing ER stress in colorectal cancer.

Cell death & disease

Xu K,Han B,Bai Y,Ma XY,Ji ZN,Xiong Y,Miao SK,Zhang YY,Zhou LM

Fri Feb 15 00:00:00 UTC 2019

Efficient proximity labeling in living cells and organisms with TurboID.

Nature biotechnology

Branon TC,Bosch JA,Sanchez AD,Udeshi ND,Svinkina T,Carr SA,Feldman JL,Perrimon N,Ting AY

Mon Oct 01 00:00:00 UTC 2018

Expansion of DUB functionality generated by alternative isoforms - USP35, a case study.

Journal of cell science

Leznicki P,Natarajan J,Bader G,Spevak W,Schlattl A,Abdul Rehman SA,Pathak D,Weidlich S,Zoephel A,Bordone MC,Barbosa-Morais NL,Boehmelt G,Kulathu Y

Wed May 16 00:00:00 UTC 2018

Expansion of DUB functionality generated by alternative isoforms - USP35, a case study.

Journal of cell science

Leznicki P,Natarajan J,Bader G,Spevak W,Schlattl A,Abdul Rehman SA,Pathak D,Weidlich S,Zoephel A,Bordone MC,Barbosa-Morais NL,Boehmelt G,Kulathu Y

Wed May 16 00:00:00 UTC 2018

FUNDC1 regulates mitochondrial dynamics at the ER-mitochondrial contact site under hypoxic conditions.

The EMBO journal

Wu W,Lin C,Wu K,Jiang L,Wang X,Li W,Zhuang H,Zhang X,Chen H,Li S,Yang Y,Lu Y,Wang J,Zhu R,Zhang L,Sui S,Tan N,Zhao B,Zhang J,Li L,Feng D

Fri Jul 01 00:00:00 UTC 2016

FUNDC1 regulates mitochondrial dynamics at the ER-mitochondrial contact site under hypoxic conditions.

The EMBO journal

Wu W,Lin C,Wu K,Jiang L,Wang X,Li W,Zhuang H,Zhang X,Chen H,Li S,Yang Y,Lu Y,Wang J,Zhu R,Zhang L,Sui S,Tan N,Zhao B,Zhang J,Li L,Feng D

Fri Jul 01 00:00:00 UTC 2016

Directed evolution of APEX2 for electron microscopy and proximity labeling.

Nature methods

Lam SS,Martell JD,Kamer KJ,Deerinck TJ,Ellisman MH,Mootha VK,Ting AY

Thu Jan 01 00:00:00 UTC 2015

Directed evolution of APEX2 for electron microscopy and proximity labeling.

Nature methods

Lam SS,Martell JD,Kamer KJ,Deerinck TJ,Ellisman MH,Mootha VK,Ting AY

Thu Jan 01 00:00:00 UTC 2015

Fis1 and Bap31 bridge the mitochondria-ER interface to establish a platform for apoptosis induction.

The EMBO journal

Iwasawa R,Mahul-Mellier AL,Datler C,Pazarentzos E,Grimm S

Wed Feb 02 00:00:00 UTC 2011

Fis1 and Bap31 bridge the mitochondria-ER interface to establish a platform for apoptosis induction.

The EMBO journal

Iwasawa R,Mahul-Mellier AL,Datler C,Pazarentzos E,Grimm S

Wed Feb 02 00:00:00 UTC 2011

Fis1 and Bap31 bridge the mitochondria-ER interface to establish a platform for apoptosis induction.

The EMBO journal

Iwasawa R,Mahul-Mellier AL,Datler C,Pazarentzos E,Grimm S

Wed Feb 02 00:00:00 UTC 2011

Fis1 and Bap31 bridge the mitochondria-ER interface to establish a platform for apoptosis induction.

The EMBO journal

Iwasawa R,Mahul-Mellier AL,Datler C,Pazarentzos E,Grimm S

Wed Feb 02 00:00:00 UTC 2011

Bioinformatics

Protein Aliases: 6C6 antigen; 6C6-AG tumor-associated antigen; accessory protein BAP31; B-cell receptor-associated protein 31; BCR-associated protein 31; BCR-associated protein Bap31; CDM protein; OTTHUMP00000025978; p28; p28 Bap31; Protein CDM

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Gene Aliases: 6C6-AG; BAP31; BCAP31; CDM; DDCH; DXS1357E

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UniProt ID: (Human) P51572, (Mouse) Q61335

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Entrez Gene ID: (Human) 10134, (Rat) 293852, (Mouse) 27061

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Function(s)

protein binding protein complex binding MHC class I protein binding

Process(es)

intracellular protein transport ER to Golgi vesicle-mediated transport immune response positive regulation of cytosolic calcium ion concentration spermatogenesis biological_process negative regulation of endoplasmic reticulum calcium ion concentration calcium-mediated signaling using intracellular calcium source positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of mitochondrial calcium ion concentration protein localization to endoplasmic reticulum exit site positive regulation of intrinsic apoptotic signaling pathway antigen processing and presentation of peptide antigen via MHC class I cellular component disassembly involved in execution phase of apoptosis positive regulation of ER-associated ubiquitin-dependent protein catabolic process positive regulation of retrograde protein transport, ER to cytosol transport apoptotic process protein transport vesicle-mediated transport

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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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BAP31 Polyclonal Antibody

BAP31 Antibody (11200-1-AP) in ICC/IF

Product Details

11200-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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