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Invitrogen
BAZ2A Polyclonal Antibody
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FIGURE: 1 / 1
BAZ2A Antibody (PA5-109445) in WB
Western blot analysis of BAZ2A in extracts of various cell lines. Samples were incubated with BAZ2A Polyclonal antibody (Product # PA5-109445) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Product Details
PA5-109445
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 97-295 of human BAZ2A (TIP5) (NP_0384772)
Conjugate
Form
Liquid
Concentration
2.48 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2854856
Product Specific Information
Immunogen sequence: QYPSANPGSN LKDPPLLSQF SGGQYPLNGI LGGSRQPSSP SHNTNLRAGS QEFWANGTQS PMGLNFDSQE LYDSFPDQNF EVMPNGPPSF FTSPQTSPML GSSIQTFAPS QEVGSGIHPD EAAEKEMTSV VAENGTGLVG SLELEEEQPE LKMCGYNGSV PSVESLHQEV SVLVPDPTVS CLDDPSHLPD QLEDTPILS
Target Information
TIP 5 is the large subunit of the nucleolar remodeling complex NoRC. NoRC causes the repression of ribosomal gene transcription. It was demonstrated that histone deacetylation is involved in this repression and that TIP5 is associated with the histone deacetylase HDAC1 and mediates the deacetylation of histones in the vicinity of the rDNA promoter. The interaction of TIP5 and HDAC1, which is necessary for transcriptional repression, is established by the C-terminal PHD finger and bromodomain.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Bromodomain adjacent to zinc finger domain protein 2A; bromodomain adjacent to zinc finger domain, 2A; hWALp3; Transcription termination factor I-interacting protein 5; TTF-I interacting peptide 5; TTF-I-interacting protein 5
Gene Aliases: AA415431; BAZ2A; C030005G16Rik; C78388; KIAA0314; mKIAA0314; TIP5; WALp3
UniProt ID: (Human) Q9UIF9
Entrez Gene ID: (Human) 11176, (Mouse) 116848
chromatin silencing at rDNA
DNA methylation
chromatin remodeling
transcription, DNA-templated
regulation of transcription, DNA-templated
histone deacetylation
chromatin modification
histone H4-K20 methylation
histone H3-K9 methylation
heterochromatin assembly involved in chromatin silencing
histone H4 deacetylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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