Proteintech

BBS2 Polyclonal Antibody

BBS2 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 4

BBS2 Antibody (11188-2-AP) in ICC/IF

IF result (cilia stain) of anti-BBS2 (11188-2-AP, 1:50) with serum-starved hTERT-RPE1 cells by Dr. Moshe Kim.

BBS2 Antibody in Immunoprecipitation (IP)

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Product Details

11188-2-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 3 publications 3 publications

Immunohistochemistry (IHC)

Assay-dependent

View 2 publications 2 publications

Immunocytochemistry (ICC/IF)

1:20-1:200

View 8 publications 8 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

BBS2 Fusion Protein Ag1662 (1-325 aa encoded by BC014140)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.33 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MLLPVFTLK LRHKISPRMV AIGRYDGTHP CLAAATQTGK VFIHNPHTRN QHVSASRVFQ SPLESDVSLL NINQAVSCLT AGVLNPELGY DALLVGTQTN LLAYDVYNNS DLFYREVADG ANVVVLGTLG DISSPLAIIG GNCALQGFNH EGSDLFWTVT GDNVNSLALC DFDGDGKKEL LVGSEDFDIR VFKEDEIVAE MTETEIVTSL CPMYGSRFGY ALSNGTVGVY DKTSRYWRIK SKNHAMSIHA FDLNSDGVNE LITGWSNGKV DARSDRTGEV IFKDNFSSAI AGVVEGDYRM DGHIQLICCS VDGEIRGYLP GTAEMR (1-325 aa encoded by B C014140)

Target Information

This gene is a member of the Bardet-Biedl syndrome (BBS) gene family. Bardet-Biedl syndrome is an autosomal recessive disorder characterized by severe pigmentary retinopathy, obesity, polydactyly, renal malformation and mental retardation. The proteins encoded by BBS gene family members are structurally diverse and the similar phenotypes exhibited by mutations in BBS gene family members is likely due to their shared roles in cilia formation and function. Many BBS proteins localize to the basal bodies, ciliary axonemes, and pericentriolar regions of cells. BBS proteins may also be involved in intracellular trafficking via microtubule-related transport. The protein encoded by this gene forms a multiprotein BBSome complex with six other BBS proteins.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Ubiquitin links smoothened to intraflagellar transport to regulate Hedgehog signaling.

The Journal of cell biology

Desai PB,Stuck MW,Lv B,Pazour GJ

Mon Jul 06 00:00:00 UTC 2020

Genetic interaction of mammalian IFT-A paralogs regulates cilia disassembly, ciliary entry of membrane protein, Hedgehog signaling, and embryogenesis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Wang W,Allard BA,Pottorf TS,Wang HH,Vivian JL,Tran PV

Fri May 01 00:00:00 UTC 2020

Single-particle tracking localization microscopy reveals nonaxonemal dynamics of intraflagellar transport proteins at the base of mammalian primary cilia.

Molecular biology of the cell

Yang TT,Tran MNT,Chong WM,Huang CE,Liao JC

Thu Mar 21 00:00:00 UTC 2019

Inhibition of Hedgehog signaling suppresses proliferation and microcyst formation of human Autosomal Dominant Polycystic Kidney Disease cells.

Scientific reports

Silva LM,Jacobs DT,Allard BA,Fields TA,Sharma M,Wallace DP,Tran PV

Wed Mar 21 00:00:00 UTC 2018

Inhibition of Hedgehog signaling suppresses proliferation and microcyst formation of human Autosomal Dominant Polycystic Kidney Disease cells.

Scientific reports

Silva LM,Jacobs DT,Allard BA,Fields TA,Sharma M,Wallace DP,Tran PV

Wed Mar 21 00:00:00 UTC 2018

Refining genotype-phenotype correlation in Alström syndrome through study of primary human fibroblasts.

Molecular genetics & genomic medicine

Chen JH,Geberhiwot T,Barrett TG,Paisey R,Semple RK

Sat Jul 01 00:00:00 UTC 2017

Refining genotype-phenotype correlation in Alström syndrome through study of primary human fibroblasts.

Molecular genetics & genomic medicine

Chen JH,Geberhiwot T,Barrett TG,Paisey R,Semple RK

Sat Jul 01 00:00:00 UTC 2017

A novel form of ciliopathy underlies hyperphagia and obesity in Ankrd26 knockout mice.

Brain structure & function

Acs P,Bauer PO,Mayer B,Bera T,Macallister R,Mezey E,Pastan I

Fri Jan 15 00:00:00 UTC 2016

A novel form of ciliopathy underlies hyperphagia and obesity in Ankrd26 knockout mice.

Brain structure & function

Acs P,Bauer PO,Mayer B,Bera T,Macallister R,Mezey E,Pastan I

Fri Jan 15 00:00:00 UTC 2016

Essential role of the chaperonin CCT in rod outer segment biogenesis.

Investigative ophthalmology & visual science

Sinha S,Belcastro M,Datta P,Seo S,Sokolov M

Thu May 22 00:00:00 UTC 2014

Essential role of the chaperonin CCT in rod outer segment biogenesis.

Investigative ophthalmology & visual science

Sinha S,Belcastro M,Datta P,Seo S,Sokolov M

Thu May 22 00:00:00 UTC 2014

A truncating mutation of Alms1 reduces the number of hypothalamic neuronal cilia in obese mice.

Developmental neurobiology

Heydet D,Chen LX,Larter CZ,Inglis C,Silverman MA,Farrell GC,Leroux MR

Tue Jan 01 00:00:00 UTC 2013

A truncating mutation of Alms1 reduces the number of hypothalamic neuronal cilia in obese mice.

Developmental neurobiology

Heydet D,Chen LX,Larter CZ,Inglis C,Silverman MA,Farrell GC,Leroux MR

Tue Jan 01 00:00:00 UTC 2013

Asymmetric segregation of the double-stranded RNA binding protein Staufen2 during mammalian neural stem cell divisions promotes lineage progression.

Cell stem cell

Kusek G,Campbell M,Doyle F,Tenenbaum SA,Kiebler M,Temple S

Fri Oct 05 00:00:00 UTC 2012

Asymmetric segregation of the double-stranded RNA binding protein Staufen2 during mammalian neural stem cell divisions promotes lineage progression.

Cell stem cell

Kusek G,Campbell M,Doyle F,Tenenbaum SA,Kiebler M,Temple S

Fri Oct 05 00:00:00 UTC 2012

The conserved Bardet-Biedl syndrome proteins assemble a coat that traffics membrane proteins to cilia.

Cell

Jin H,White SR,Shida T,Schulz S,Aguiar M,Gygi SP,Bazan JF,Nachury MV

Fri Jun 25 00:00:00 UTC 2010

The conserved Bardet-Biedl syndrome proteins assemble a coat that traffics membrane proteins to cilia.

Cell

Jin H,White SR,Shida T,Schulz S,Aguiar M,Gygi SP,Bazan JF,Nachury MV

Fri Jun 25 00:00:00 UTC 2010

Essential role of nephrocystin in photoreceptor intraflagellar transport in mouse.

Human molecular genetics

Jiang ST,Chiou YY,Wang E,Chien YL,Ho HH,Tsai FJ,Lin CY,Tsai SP,Li H

Fri May 01 00:00:00 UTC 2009

Essential role of nephrocystin in photoreceptor intraflagellar transport in mouse.

Human molecular genetics

Jiang ST,Chiou YY,Wang E,Chien YL,Ho HH,Tsai FJ,Lin CY,Tsai SP,Li H

Fri May 01 00:00:00 UTC 2009

Patterns of expression of Bardet-Biedl syndrome proteins in the mammalian cochlea suggest noncentrosomal functions.

The Journal of comparative neurology