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Invitrogen
BBS2 Polyclonal Antibody
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FIGURE: 1 / 1
BBS2 Antibody (PA5-96671) in WB
Western blot analysis of BBS2 in extracts of various cell lines. Samples were incubated with BBS2 Polyclonal antibody (Product # PA5-96671) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 5s.
Product Details
PA5-96671
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-96 of human BBS2 (NP_1140913)
Conjugate
Form
Liquid
Concentration
1.58 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2808473
Product Specific Information
Immunogen sequence: MLLPVFTLKL RHKISPRMVA IGRYDGTHPC LAAATQTGKV FIHNPHTRNQ HVSASRVFQS PLESDVSLLN INQAVSCLTA GVLNPELGYD ALLVGT; Positive Samples: Mouse testis, Mouse liver, Mouse kidney, Rat liver, Rat brain, Rat lung; Cellular Location: Cell projection, Cytoplasm, centriolar satellite, centrosome, cilium membrane, cytoskeleton, microtubule organizing center
Target Information
This gene is a member of the Bardet-Biedl syndrome (BBS) gene family. Bardet-Biedl syndrome is an autosomal recessive disorder characterized by severe pigmentary retinopathy, obesity, polydactyly, renal malformation and mental retardation. The proteins encoded by BBS gene family members are structurally diverse and the similar phenotypes exhibited by mutations in BBS gene family members is likely due to their shared roles in cilia formation and function. Many BBS proteins localize to the basal bodies, ciliary axonemes, and pericentriolar regions of cells. BBS proteins may also be involved in intracellular trafficking via microtubule-related transport. The protein encoded by this gene forms a multiprotein BBSome complex with six other BBS proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Bardet-Biedl syndrome 2 homolog; Bardet-Biedl syndrome 2 protein homolog; BBSome complex member BBS2; MGC20703
Gene Aliases: 2410125H22Rik; AI447581; Bbs2
UniProt ID: (Rat) Q99MH9, (Mouse) Q9CWF6
Entrez Gene ID: (Rat) 113948, (Mouse) 67378
sperm axoneme assembly
protein localization
biological_process
negative regulation of gene expression
artery smooth muscle contraction
striatum development
hippocampus development
cerebral cortex development
adult behavior
leptin-mediated signaling pathway
protein localization to organelle
nonmotile primary cilium assembly
negative regulation of appetite by leptin-mediated signaling pathway
negative regulation of multicellular organism growth
positive regulation of multicellular organism growth
vasodilation
cilium assembly
Golgi to plasma membrane protein transport
response to leptin
fat cell differentiation
photoreceptor cell maintenance
brain morphogenesis
cartilage development
cilium morphogenesis
regulation of cilium beat frequency involved in ciliary motility
protein localization to ciliary membrane
transport
protein transport
cell projection organization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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