Invitrogen

BBS4 Monoclonal Antibody (1292CT845.130.218)

View all (14) BBS4 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-37638

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

1292CT845.130.218

Immunogen

recombinant protein between 1-240 amino acids from human BBS4
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Protein G

Storage buffer

PBS, pH 7.4

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2897564

Target Information

BBS4 contains tetratricopeptide repeats (TPR), similar to O-linked N-acetyglucosamine transferase. Mutations in the gene encoding this protein have been observed in patients with Bardet-Biedl syndrome type 4. BBS4 may play a role in pigmentary retinopathy, obesity, polydactyly, renal malformation and mental retardation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Bardet-Biedl syndrome 4 homolog; Bardet-Biedl syndrome 4 protein; Bardet-Biedl syndrome 4 protein homolog; BBSome complex member BBS4

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Gene Aliases: AW537059; AW742241; BBS4; D9Ertd464e

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UniProt ID: (Human) Q96RK4, (Mouse) Q8C1Z7

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Entrez Gene ID: (Human) 585, (Mouse) 102774, (Rat) 300754

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Function(s)
RNA polymerase II repressing transcription factor binding microtubule motor activity protein binding dynactin binding alpha-tubulin binding beta-tubulin binding molecular_function
Process(es)
microtubule cytoskeleton organization mitotic cytokinesis neural tube closure retina homeostasis negative regulation of systemic arterial blood pressure transport spermatid development sensory perception of smell protein localization metabolic process negative regulation of gene expression protein transport dendrite development regulation of lipid metabolic process ventricular system development striatum development hippocampus development cerebral cortex development cell projection organization adult behavior negative regulation of actin filament polymerization regulation of cytokinesis leptin-mediated signaling pathway protein localization to organelle negative regulation of GTPase activity microtubule anchoring at centrosome nonmotile primary cilium assembly social behavior photoreceptor cell outer segment organization negative regulation of appetite by leptin-mediated signaling pathway positive regulation of multicellular organism growth cilium assembly response to leptin photoreceptor cell maintenance positive regulation of cilium assembly retinal rod cell development brain morphogenesis centrosome organization maintenance of protein location in nucleus regulation of stress fiber assembly cilium morphogenesis regulation of cilium beat frequency involved in ciliary motility face development fat pad development protein localization to cilium protein localization to centrosome regulation of nonmotile primary cilium assembly protein localization to photoreceptor outer segment neuron migration heart looping visual perception melanosome transport fat cell differentiation intracellular transport sensory processing biological_process
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