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Product Details
13628-1-AP
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
BCAR3 Fusion Protein Ag4546 (475-825 aa encoded by BC039895)
Conjugate
Form
Liquid
Concentration
0.14 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: YLILDDDDR ERPWEPAAAQ MEKGQWDKGE FVTPLLETVS SFRPNEFESK FLPPENKPLE TAMLKRAKEL FTNNDPKVIA QHVLSMDCRV ARILGVSEEM RRNMGVSSGL ELITLPHGHQ LRLDIIERHN TMAIGIAVDI LGCTGTLEDR AATLSKIIQV AVELKDSMGD LYSFSALMKA LEMPQITRLE KTWTALRHQY TQTAILYEKQ LKPFSKLLHE GRESTCVPPN NVSVPLLMPL VTLMERQAVT FEGTDMWEKN DQSCEIMLNH LATARFMAEA ADSYRMNAER ILAGFQPDEE MNEICKTEFQ MRLLWGSKGA QVNQTERYEK FNQILTALSR KLEPPPVKQA EL (475-825 aa encoded by BC039895)
Target Information
Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BCAR3 adapter protein, NSP family member; Breast cancer anti-estrogen resistance protein 3; Breast cancer anti-estrogen resistance protein 3 homolog; breast cancer antiestrogen resistance 3 protein; dJ1033H22.2 (breast cancer anti-estrogen resistance 3); KIAA0554; Novel SH2-containing protein 2; OTTHUMP00000011961; p130Cas-binding protein AND-34; SH2 domain-containing protein 3B
Gene Aliases: AI131758; AND-34; And34; BCAR3; NSP2; SH2D3B; UNQ271/PRO308
UniProt ID: (Human) O75815, (Mouse) Q9QZK2, (Rat) D3ZAZ5
Entrez Gene ID: (Human) 8412, (Mouse) 29815, (Rat) 310838
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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