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Product Details
25776-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
BCAS1 Fusion Protein Ag22760 (1-289 aa encoded by BC126348)
Conjugate
Form
Liquid
Concentration
0.43 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MGNQMSVPQ RVEDQENEPE AETYKDNASA LNGVPVVVST HTVQHLEEVD LGISVKTDNV ATSSPETTEI SAVADANGKN LGKEAKPEAP AAKSRFFLML SRPVPGRTGD QAADSSLGSV KLDVSSNKAP ANKDPSESWT LPVAAGPGQD TDKTPGHAPA QDKALSAARD PTLLPPETGG AGGEAPSKPK DSSFFDKFFK LDKGQEKVPG DSQQEAKRAE HQDKVDEVPG LSGQSDDVPA GKDIVDGKEK EGQELGTADC SVPGDPEGLE TAKDDSQAAA IAENNNSIMS (1-289 aa encoded by BC126348)
Target Information
BCAS1 was identified through positional cloning and was found to be overexpressed in most but not all breast cancer cells lines. Little is known about this protein; BCAS1 is cytoplasmically localized and is thought to form homodimers through coiled-coil structures. High levels of BCAS1 mRNA are seen in brain and prostate tissues, with lower amounts observed in colon, intestine and testis. Cells engineered to overexpress BCAS1 did not lose anchorage-dependent growth or increase their rate of growth, suggesting that BCAS1 is not a prototypical oncogene. The BCAS1 gene was also found to be amplified in other carcinomas such as pancreatic carcinoma, suggesting that BCAS1 may play in important role in the control of cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Amplified and overexpressed in breast cancer; amplified in breast cancer 1; Breast carcinoma-amplified sequence 1; Breast carcinoma-amplified sequence 1 homolog; Novel amplified in breast cancer 1; Novel amplified in breast cancer 1 homolog
Gene Aliases: 2210416M21Rik; 9030223A09Rik; AI841227; AIBC1; BCAS1; NABC1
UniProt ID: (Human) O75363, (Mouse) Q80YN3
Entrez Gene ID: (Human) 8537, (Mouse) 76960
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