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cDNA encoding BCAS2 has been isolated. The deduced 225-amino acid protein contains a central potential N-glycosylation site and multiple N-terminal potential phosphorylation sites. Northern and Southern blot analyses demonstrates expression of a 1.5-kb transcript at various levels in multiple breast cancer cell lines, with greatest amplification in BT-20 and MCF-7 cells. BCAS2 is ubiquitously expressed in normal tissues.
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Protein Aliases: Breast carcinoma-amplified sequence 2; DNA amplified in mammary carcinoma 1 protein; Pre-mRNA-splicing factor SPF27; spliceosome associated protein, amplified in breast cancer; Spliceosome-associated protein SPF 27
Gene Aliases: BCAS2; DAM1; Snt309; SPF27
UniProt ID: (Human) O75934
Entrez Gene ID: (Human) 10286
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